PIGF

PIGF
Identifiers
Aliases	PIGF , phosphatidylinositol glycan anchor biosynthesis class F, OORS
External IDs	OMIM: 600153 MGI: 99462 HomoloGene: 31103 GeneCards: PIGF
Gene location (Human)
Chr.	Chromosome 2 (human)
End	46,617,055 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	87,332,834 bp
RNA expression pattern
	Top expressed in
	oocyte; ; islet of Langerhans; ; right adrenal gland; ; rectum; ; left adrenal gland; ; monocyte; ; stromal cell of endometrium; ; body of pancreas; ; Achilles tendon; ; gallbladder;
	Top expressed in
	spermatid; ; secondary oocyte; ; spermatocyte; ; seminiferous tubule; ; Paneth cell; ; epithelium of stomach; ; primitive streak; ; yolk sac; ; pyloric antrum; ; condyle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ethanolaminephosphotransferase activity ;
Cellular component	integral component of membrane ; endoplasmic reticulum membrane ; endoplasmic reticulum ; membrane ;
Biological process	GPI anchor biosynthetic process ; preassembly of GPI anchor in ER membrane ;
	Sources:Amigo / QuickGO
Orthologs
	5281
	18701
	ENSG00000151665
	ENSMUSG00000024145
	Q07326
	O09101
	NM_002643 ; NM_173074
	NM_008838
	NP_002634 ; NP_775097
	NP_032864
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 31, 2023

Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.^[5]^[6]^[7]

Function

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least two alternatively spliced transcripts encoding distinct isoforms have been found for this gene.^[7]

Related Research Articles

Lipid-anchored proteins are proteins located on the surface of the cell membrane that are covalently attached to lipids embedded within the cell membrane. These proteins insert and assume a place in the bilayer structure of the membrane alongside the similar fatty acid tails. The lipid-anchored protein can be located on either side of the cell membrane. Thus, the lipid serves to anchor the protein to the cell membrane. They are a type of proteolipids.

In enzymology, a N-acetylglucosaminylphosphatidylinositol deacetylase (EC 3.5.1.89) is an enzyme that catalyzes the chemical reaction

In enzymology, a phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme that catalyzes the chemical reaction

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A is the catalytic subunit of the phosphatidylinositol N-acetylglucosaminyltransferase enzyme, which in humans is encoded by the PIGA gene.

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.

GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.

Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.

Dolichol-phosphate mannosyltransferase is an enzyme that in humans is encoded by the DPM1 gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.

GPI transamidase component PIG-S is an enzyme that in humans is encoded by the PIGS gene. This gene encodes a protein that is involved in GPI-anchor biosynthesis.

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene.

Subunit P of phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme subunit that in humans is encoded by the PIGP gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene. The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.

GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene.

dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.

Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the DPM2 gene.

Glypiation is the addition by covalent bonding of a glycosylphosphatidylinositol (GPI) anchor and is a common post-translational modification that localizes proteins to cell membranes. This special kind of glycosylation is widely detected on surface glycoproteins in eukaryotes and some Archaea.

Phosphatidylinositol glycan anchor biosynthesis, class N is a protein that in humans is encoded by the PIGN gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151665 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024145 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Oct 1995). "Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF". Genomics. 29 (3): 804–807. doi:10.1006/geno.1995.9929. PMID 8575782.
↑ Inoue N, Kinoshita T, Orii T, Takeda J (Apr 1993). "Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy". The Journal of Biological Chemistry. 268 (10): 6882–6885. doi: 10.1016/S0021-9258(18)53122-7 . PMID 8463218.
1 2 "Entrez Gene: PIGF phosphatidylinositol glycan anchor biosynthesis, class F".

Kinoshita T, Takahashi M, Inoue N, Miyata T, Takeda J (Feb 1994). "Expression cloning of genes for GPI-anchor biosynthesis". Brazilian Journal of Medical and Biological Research. 27 (2): 127–132. PMID 8081220.
Hong Y, Maeda Y, Watanabe R, Inoue N, Ohishi K, Kinoshita T (Jul 2000). "Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol". The Journal of Biological Chemistry. 275 (27): 20911–20919. doi:10.1074/jbc.M001913200. PMID 10781593.
Shishioh N, Hong Y, Ohishi K, Ashida H, Maeda Y, Kinoshita T (Mar 2005). "GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol". The Journal of Biological Chemistry. 280 (10): 9728–9734. doi: 10.1074/jbc.M413755200 . PMID 15632136.
Li W, Shen W, Gill R, Corbly A, Jones B, Belagaje R, Zhang Y, Tang S, Chen Y, Zhai Y, Wang G, Wagle A, Hui K, Westmore M, Hanson J, Chen YF, Simons M, Singh J (May 2006). "High-resolution quantitative computed tomography demonstrating selective enhancement of medium-size collaterals by placental growth factor-1 in the mouse ischemic hindlimb". Circulation. 113 (20): 2445–2453. doi: 10.1161/CIRCULATIONAHA.105.586818 . PMID 16702473.
Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC (Jun 2006). "Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality" (PDF). The Journal of Experimental Medicine. 203 (6): 1447–1458. doi:10.1084/jem.20060375. PMC 2118329 . PMID 16702604.
Zheng Y, Murakami M, Takahashi H, Yamauchi M, Kiba A, Yamaguchi S, Yabana N, Alitalo K, Shibuya M (Sep 2006). "Chimeric VEGF-E(NZ7)/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation". Arteriosclerosis, Thrombosis, and Vascular Biology. 26 (9): 2019–2026. doi: 10.1161/01.ATV.0000233336.53574.a1 . PMID 16794222.
Mohammed KA, Nasreen N, Tepper RS, Antony VB (Feb 2007). "Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release". American Journal of Physiology. Lung Cellular and Molecular Physiology. 292 (2): L559–566. doi:10.1152/ajplung.00075.2006. PMID 17028267.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000151665 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024145 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8575782-5] Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Oct 1995). "Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF". Genomics. 29 (3): 804–807. doi:10.1006/geno.1995.9929. PMID 8575782.

[pmid8463218-6] Inoue N, Kinoshita T, Orii T, Takeda J (Apr 1993). "Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy". The Journal of Biological Chemistry. 268 (10): 6882–6885. doi: 10.1016/S0021-9258(18)53122-7 . PMID 8463218.

[entrez-7] 1 2 "Entrez Gene: PIGF phosphatidylinositol glycan anchor biosynthesis, class F".

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PIGF

Contents

Function

See also

Related Research Articles

References

Further reading