PIGQ

PIGQ
Identifiers
Aliases	PIGQ , GPI1, c407A10.1, phosphatidylinositol glycan anchor biosynthesis class Q, EIEE77, DEE77, MCAHS4, GPIBD19
External IDs	OMIM: 605754; MGI: 1333114; HomoloGene: 31228; GeneCards: PIGQ; OMA:PIGQ - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 566,995 bp [1] End 584,109 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A3.3 Start 26,145,395 bp [2] End 26,163,910 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland right uterine tube left lobe of thyroid gland right testis anterior pituitary left testis right frontal lobe body of pancreas right hemisphere of cerebellum right adrenal cortex Top expressed in fetal liver hematopoietic progenitor cell motor neuron substantia nigra fossa ciliary body endocardial cushion barrel cortex medullary collecting duct ascending aorta crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity phosphatidylinositol N-acetylglucosaminyltransferase activity glycosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex membrane Biological process GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9091 14755 Ensembl ENSG00000007541 ENSMUSG00000025728 UniProt Q9BRB3 Q9QYT7 RefSeq (mRNA) NM_148920 NM_004204 NM_001291025 NM_011822 NM_001357592 RefSeq (protein) NP_004195 NP_683721 NP_001277954 NP_035952 NP_001344521 Location (UCSC) Chr 16: 0.57 – 0.58 Mb Chr 17: 26.15 – 26.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene. ^{[5] [6] [7]}

This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). ^[7]

Interactions

PIGQ has been shown to interact with PIGH, ^[5] PIGA ^[5] and PIGC. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000007541 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025728 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T (Mar 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. 17 (4): 877–85. doi:10.1093/emboj/17.4.877. PMC   1170437 . PMID   9463366.
6. Tiede A, Schubert J, Nischan C, Jensen I, Westfall B, Taron CH, Orlean P, Schmidt RE (Nov 1998). "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants". Biochem J. 334 (3): 609–16. doi:10.1042/bj3340609. PMC   1219730 . PMID   9729469.
7. "Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi: 10.1038/nature03187 . PMID   15616553.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tiede A, Daniels RJ, Higgs DR, et al. (2001). "The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis". Gene. 271 (2): 247–54. doi:10.1016/S0378-1119(01)00510-8. PMID   11418246.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID   11157797.
• Watanabe R, Murakami Y, Marmor MD, et al. (2000). "Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2". EMBO J. 19 (16): 4402–11. doi:10.1093/emboj/19.16.4402. PMC   302040 . PMID   10944123.
• Hong Y, Ohishi K, Watanabe R, et al. (1999). "GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis". J. Biol. Chem. 274 (26): 18582–8. doi: 10.1074/jbc.274.26.18582 . PMID   10373468.
• Watanabe R, Kinoshita T, Masaki R, et al. (1996). "PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum". J. Biol. Chem. 271 (43): 26868–75. doi: 10.1074/jbc.271.43.26868 . PMID   8900170.