PIGS (gene)

PIGS
Identifiers
Aliases	PIGS , phosphatidylinositol glycan anchor biosynthesis class S, GPIBD18, DEE95
External IDs	OMIM: 610271; MGI: 2687325; HomoloGene: 41963; GeneCards: PIGS; OMA:PIGS - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,571,794 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,233,608 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; granulocyte; ; islet of Langerhans; ; mucosa of transverse colon; ; rectum; ; duodenum; ; monocyte; ; left ventricle; ; right hemisphere of cerebellum; ; blood;
	Top expressed in
	choroid plexus of fourth ventricle; ; spermatocyte; ; entorhinal cortex; ; perirhinal cortex; ; stroma of bone marrow; ; lens; ; muscle of thigh; ; granulocyte; ; lactiferous gland; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; GPI-anchor transamidase activity ;
Cellular component	integral component of membrane ; GPI-anchor transamidase complex ; endoplasmic reticulum membrane ; membrane ; endoplasmic reticulum ;
Biological process	attachment of GPI anchor to protein ; GPI anchor biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	94005
	276846
	ENSG00000087111
	ENSMUSG00000041958
	Q96S52
	Q6PD26
	NM_033198
	NM_201406
	NP_149975
	NP_958808
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 16, 2024

GPI transamidase component PIG-S is an enzyme that in humans is encoded by the PIGS gene.^[5] This gene encodes a protein that is involved in GPI-anchor biosynthesis.

The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.^[5]

Related Research Articles

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A is the catalytic subunit of the phosphatidylinositol N-acetylglucosaminyltransferase enzyme, which in humans is encoded by the PIGA gene.

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.

Pancreatic secretory granule membrane major glycoprotein GP2 is a protein that in humans is encoded by the GP2 gene.

Matrix metalloproteinase-17 (MMP-17) also known as membrane-type matrix metalloproteinase 4 is an enzyme that in humans is encoded by the MMP17 gene.

GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene. Either GNGT1 or GNGT2 is the gamma subunit (G_γ) of the G_βγ part of transducin, a heterotrimeric G-protein naturally expressed in vertebrate retina rod and cone cells. GNGT1 only occurs in rod cells, and GNGT2 only occurs in cone cells, with a different alpha (G_α) subunit.

Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.

Protein transport protein Sec61 subunit alpha isoform 1 is a protein encoded by the SEC61A1 gene in humans.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.

Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b, is a human gene.

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene.

Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene. The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.

Glypican-6 is a protein that in humans is encoded by the GPC6 gene.

dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.

Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the DPM2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000087111 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041958 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: PIGS phosphatidylinositol glycan anchor biosynthesis, class S".

Ohishi K, Inoue N, Kinoshita T (2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8". EMBO J. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. PMC 149153 . PMID 11483512.
Vainauskas S, Maeda Y, Kurniawan H, et al. (2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. 277 (34): 30535–42. doi: 10.1074/jbc.M205402200 . PMID 12052837.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ohishi K, Nagamune K, Maeda Y, Kinoshita T (2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge". J. Biol. Chem. 278 (16): 13959–67. doi: 10.1074/jbc.M300586200 . PMID 12582175.
Hong Y, Ohishi K, Kang JY, et al. (2004). "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins". Mol. Biol. Cell. 14 (5): 1780–9. doi:10.1091/mbc.E02-12-0794. PMC 165076 . PMID 12802054.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Vainauskas S, Menon AK (2005). "Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. 280 (16): 16402–9. doi: 10.1074/jbc.M414253200 . PMID 15713669.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000087111 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041958 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: PIGS phosphatidylinositol glycan anchor biosynthesis, class S".

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[5]

PIGS (gene)

Related Research Articles

References

Further reading