PIGT

Last updated
PIGT
Identifiers
Aliases PIGT , MCAHS3, NDAP, PNH2, CGI-06, phosphatidylinositol glycan anchor biosynthesis class T
External IDs OMIM: 610272 MGI: 1926178 HomoloGene: 6134 GeneCards: PIGT
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001184728
NM_001184729
NM_001184730
NM_015937

NM_133779
NM_001362644
NM_001362645
NM_001378795

RefSeq (protein)

NP_001171657
NP_001171658
NP_001171659
NP_057021

NP_598540
NP_001349573
NP_001349574
NP_001365724
NP_001394210

Contents

Location (UCSC) Chr 20: 45.42 – 45.46 Mb Chr 2: 164.34 – 164.35 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene. [5] [6] [7]

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [6]

Interactions

PIGT has been shown to interact with PIGK [8] and GPAA1. [7] [9]

Related Research Articles

In enzymology, a N-acetylglucosaminylphosphatidylinositol deacetylase (EC 3.5.1.89) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">PIGA</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A is the catalytic subunit of the phosphatidylinositol N-acetylglucosaminyltransferase enzyme, which in humans is encoded by the PIGA gene.

<span class="mw-page-title-main">MMP17</span> Protein-coding gene in the species Homo sapiens

Matrix metalloproteinase-17 (MMP-17) also known as membrane-type matrix metalloproteinase 4 is an enzyme that in humans is encoded by the MMP17 gene.

<span class="mw-page-title-main">TOMM22</span> Protein-coding gene in the species Homo sapiens

Mitochondrial import receptor subunit TOM22 homolog(hTom22) is a protein that in humans is encoded by the TOMM22 gene.

<span class="mw-page-title-main">PIGK</span> Protein-coding gene in the species Homo sapiens

GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.

<span class="mw-page-title-main">GPAA1</span> Protein-coding gene in the species Homo sapiens

Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.

<span class="mw-page-title-main">SEMA7A</span> Protein-coding gene in the species Homo sapiens

Semaphorin 7A, GPI membrane anchor (SEMA7A) also known as CD108, is a human gene.

<span class="mw-page-title-main">PIGQ</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.

<span class="mw-page-title-main">PIGC</span> Enzyme

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.

<span class="mw-page-title-main">PIGF</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.

<span class="mw-page-title-main">PIGS (gene)</span> Protein-coding gene in the species Homo sapiens

GPI transamidase component PIG-S is an enzyme that in humans is encoded by the PIGS gene. This gene encodes a protein that is involved in GPI-anchor biosynthesis.

<span class="mw-page-title-main">PIGU</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.

<span class="mw-page-title-main">IL18RAP</span> Protein-coding gene in the species Homo sapiens

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b, is a human gene.

<span class="mw-page-title-main">PIGB</span> Protein-coding gene in the species Homo sapiens

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene.

<span class="mw-page-title-main">PIGH</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene. The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.

<span class="mw-page-title-main">PIGV</span> Protein-coding gene in the species Homo sapiens

GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene.

<span class="mw-page-title-main">Glypican 6</span> Protein-coding gene in the species Homo sapiens

Glypican-6 is a protein that in humans is encoded by the GPC6 gene.

<span class="mw-page-title-main">DPM3</span> Protein-coding gene in the species Homo sapiens

dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.

<span class="mw-page-title-main">DPM2</span> Protein-coding gene in the species Homo sapiens

Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the DPM2 gene.

<span class="mw-page-title-main">PIGN (gene)</span> Protein-coding gene in the species Homo sapiens

Phosphatidylinositol glycan anchor biosynthesis, class N is a protein that in humans is encoded by the PIGN gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000124155 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017721 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vainauskas S, Menon AK (Apr 2005). "Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex". J Biol Chem. 280 (16): 16402–9. doi: 10.1074/jbc.M414253200 . PMID   15713669.
  6. 1 2 "Entrez Gene: PIGT phosphatidylinositol glycan anchor biosynthesis, class T".
  7. 1 2 Ohishi K, Inoue N, Kinoshita T (August 2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8". EMBO J. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. PMC   149153 . PMID   11483512.
  8. Ohishi K, Nagamune Kisaburo, Maeda Yusuke, Kinoshita Taroh (Apr 2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge". J. Biol. Chem. 278 (16): 13959–67. doi: 10.1074/jbc.M300586200 . ISSN   0021-9258. PMID   12582175.
  9. Vainauskas S, Maeda Yusuke, Kurniawan Henry, Kinoshita Taroh, Menon Anant K (Aug 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. 277 (34): 30535–42. doi: 10.1074/jbc.M205402200 . ISSN   0021-9258. PMID   12052837.

Further reading