PIGU

PIGU
Identifiers
Aliases	PIGU , CDC91L1, GAB1, phosphatidylinositol glycan anchor biosynthesis class U, GPIBD21, NEDBSS
External IDs	OMIM: 608528; MGI: 3039607; HomoloGene: 6553; GeneCards: PIGU; OMA:PIGU - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.22 Start 34,560,542 bp [1] End 34,698,790 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 155,120,163 bp [2] End 155,199,350 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon ganglionic eminence ventricular zone islet of Langerhans C1 segment oocyte tibialis anterior muscle gonad rectum right uterine tube Top expressed in external carotid artery internal carotid artery genital tubercle tail of embryo muscle of thigh yolk sac right kidney proximal tubule conjunctival fornix primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function GPI-anchor transamidase activity GPI anchor binding Cellular component integral component of membrane integral component of endoplasmic reticulum membrane plasma membrane endoplasmic reticulum membrane membrane endoplasmic reticulum GPI-anchor transamidase complex Biological process GPI anchor biosynthetic process regulation of receptor signaling pathway via JAK-STAT attachment of GPI anchor to protein protein localization to cell surface Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 128869 228812 Ensembl ENSG00000101464 ENSMUSG00000038383 UniProt Q9H490 Q3TAA8 RefSeq (mRNA) NM_080476 NM_001004721 RefSeq (protein) NP_536724 NP_001004721 Location (UCSC) Chr 20: 34.56 – 34.7 Mb Chr 2: 155.12 – 155.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene. ^{[5] [6] [7]}

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000101464 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038383 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hong Y, Ohishi K, Kang JY, Tanaka S, Inoue N, Nishimura J, Maeda Y, Kinoshita T (Jun 2003). "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins". Mol Biol Cell. 14 (5): 1780–9. doi:10.1091/mbc.E02-12-0794. PMC   165076 . PMID   12802054.
6. Guo Z, Linn JF, Wu G, Anzick SL, Eisenberger CF, Halachmi S, Cohen Y, Fomenkov A, Hoque MO, Okami K, Steiner G, Engles JM, Osada M, Moon C, Ratovitski E, Trent JM, Meltzer PS, Westra WH, Kiemeney LA, Schoenberg MP, Sidransky D, Trink B (Apr 2004). "CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer". Nat Med. 10 (4): 374–81. doi:10.1038/nm1010. PMID   15034568. S2CID   900186.
7. "Entrez Gene: PIGU phosphatidylinositol glycan anchor biosynthesis, class U".

Further reading

• Ohishi K, Inoue N, Kinoshita T (2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8". EMBO J. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. PMC   149153 . PMID   11483512.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Vainauskas S, Menon AK (2004). "A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase". J. Biol. Chem. 279 (8): 6540–5. doi: 10.1074/jbc.M312191200 . PMID   14660601.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.