PIGU

PIGU
Identifiers
Aliases	PIGU , CDC91L1, GAB1, phosphatidylinositol glycan anchor biosynthesis class U, GPIBD21, NEDBSS
External IDs	OMIM: 608528 MGI: 3039607 HomoloGene: 6553 GeneCards: PIGU
Gene location (Human)
Chr.	Chromosome 20 (human)
End	34,698,790 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,199,350 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; islet of Langerhans; ; oocyte; ; tibialis anterior muscle; ; rectum; ; right uterine tube; ; secondary oocyte; ; smooth muscle tissue; ; tibial nerve; ; stromal cell of endometrium;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; yolk sac; ; proximal tubule; ; conjunctival fornix; ; lip; ; atrium; ; molar; ; neural tube; ; intercostal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	GPI-anchor transamidase activity ; GPI anchor binding ;
Cellular component	integral component of membrane ; integral component of endoplasmic reticulum membrane ; plasma membrane ; endoplasmic reticulum membrane ; membrane ; endoplasmic reticulum ; GPI-anchor transamidase complex ;
Biological process	GPI anchor biosynthetic process ; regulation of receptor signaling pathway via JAK-STAT ; attachment of GPI anchor to protein ; protein localization to cell surface ;
	Sources:Amigo / QuickGO
Orthologs
	128869
	228812
	ENSG00000101464
	ENSMUSG00000038383
	Q9H490
	Q3TAA8
	NM_080476
	NM_001004721
	NP_536724
	NP_001004721
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.^[5]^[6]^[7]

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins.^[7]

Related Research Articles

In enzymology, a dolichol kinase is an enzyme that catalyzes the chemical reaction

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A is the catalytic subunit of the phosphatidylinositol N-acetylglucosaminyltransferase enzyme, which in humans is encoded by the PIGA gene.

Phosphatidylinositol-glycan-specific phospholipase D is an enzyme that in humans is encoded by the GPLD1 gene.

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.

GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.

Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.

Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.

GPI transamidase component PIG-S is an enzyme that in humans is encoded by the PIGS gene. This gene encodes a protein that is involved in GPI-anchor biosynthesis.

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene.

Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene.

Subunit P of phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the PIGP gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene. The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.

GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene.

Glypican-6 is a protein that in humans is encoded by the GPC6 gene.

dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.

Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the DPM2 gene.

Phosphatidylinositol glycan anchor biosynthesis, class N is a protein that in humans is encoded by the PIGN gene.

Phosphatidylinositol glycan anchor biosynthesis class W is a protein that in humans is encoded by the PIGW gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101464 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038383 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hong Y, Ohishi K, Kang JY, Tanaka S, Inoue N, Nishimura J, Maeda Y, Kinoshita T (Jun 2003). "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins". Mol Biol Cell. 14 (5): 1780–9. doi:10.1091/mbc.E02-12-0794. PMC 165076 . PMID 12802054.
↑ Guo Z, Linn JF, Wu G, Anzick SL, Eisenberger CF, Halachmi S, Cohen Y, Fomenkov A, Hoque MO, Okami K, Steiner G, Engles JM, Osada M, Moon C, Ratovitski E, Trent JM, Meltzer PS, Westra WH, Kiemeney LA, Schoenberg MP, Sidransky D, Trink B (Apr 2004). "CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer". Nat Med. 10 (4): 374–81. doi:10.1038/nm1010. PMID 15034568. S2CID 900186.
1 2 "Entrez Gene: PIGU phosphatidylinositol glycan anchor biosynthesis, class U".

Ohishi K, Inoue N, Kinoshita T (2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8". EMBO J. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. PMC 149153 . PMID 11483512.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Vainauskas S, Menon AK (2004). "A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase". J. Biol. Chem. 279 (8): 6540–5. doi: 10.1074/jbc.M312191200 . PMID 14660601.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101464 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038383 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12802054-5] Hong Y, Ohishi K, Kang JY, Tanaka S, Inoue N, Nishimura J, Maeda Y, Kinoshita T (Jun 2003). "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins". Mol Biol Cell. 14 (5): 1780–9. doi:10.1091/mbc.E02-12-0794. PMC 165076 . PMID 12802054.

[pmid15034568-6] Guo Z, Linn JF, Wu G, Anzick SL, Eisenberger CF, Halachmi S, Cohen Y, Fomenkov A, Hoque MO, Okami K, Steiner G, Engles JM, Osada M, Moon C, Ratovitski E, Trent JM, Meltzer PS, Westra WH, Kiemeney LA, Schoenberg MP, Sidransky D, Trink B (Apr 2004). "CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer". Nat Med. 10 (4): 374–81. doi:10.1038/nm1010. PMID 15034568. S2CID 900186.

[entrez-7] 1 2 "Entrez Gene: PIGU phosphatidylinositol glycan anchor biosynthesis, class U".

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PIGU

Related Research Articles

References

Further reading