PIGW

PIGW
Identifiers
Aliases	PIGW , Gwt1, HPMRS5, phosphatidylinositol glycan anchor biosynthesis class W
External IDs	OMIM: 610275 MGI: 1917575 HomoloGene: 6243 GeneCards: PIGW
Gene location (Human)
Chr.	Chromosome 17 (human)
End	36,539,310 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	84,771,111 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; endometrium; ; gastrocnemius muscle; ; appendix; ; rectum; ; skeletal muscle tissue; ; lymph node; ; stromal cell of endometrium; ; thymus; ; smooth muscle tissue;
	Top expressed in
	mirror; ; quadriceps femoris muscle; ; hepatobiliary system; ; liver; ; white adipose tissue; ; ileum; ; yolk sac; ; skeletal muscle tissue; ; placenta; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	acyltransferase activity ; transferase activity ; O-acyltransferase activity ; glucosaminyl-phosphatidylinositol O-acyltransferase activity ;
Cellular component	membrane ; endoplasmic reticulum membrane ; integral component of membrane ; endoplasmic reticulum ;
Biological process	GPI anchor biosynthetic process ; GPI anchor metabolic process ; protein localization to plasma membrane ; preassembly of GPI anchor in ER membrane ;
	Sources:Amigo / QuickGO
Orthologs
	284098
	70325
	ENSG00000275600 ; ENSG00000277161
	ENSMUSG00000045140
	Q7Z7B1
	Q8C398
	NM_178517 ; NM_001346754 ; NM_001346755
	NM_001077636 ; NM_027388 ; NM_001363112
	NP_001333683 ; NP_001333684 ; NP_848612
	NP_001071104 ; NP_081664 ; NP_001350041
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Phosphatidylinositol glycan anchor biosynthesis class W is a protein that in humans is encoded by the PIGW gene. ^[5]

Function

Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 [PubMed 14517336]).

Related Research Articles

Phosphatidylinositol transfer protein alpha isoform is a protein that in humans is encoded by the PITPNA gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A is the catalytic subunit of the phosphatidylinositol N-acetylglucosaminyltransferase enzyme, which in humans is encoded by the PIGA gene.

Phosphatidylinositol-glycan-specific phospholipase D is an enzyme that in humans is encoded by the GPLD1 gene.

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.

GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.

Phosphatidylinositol-glycan biosynthesis class F protein is a protein that in humans is encoded by the PIGF gene.

Phosphatidylinositol transfer protein beta isoform is a protein that in humans is encoded by the PITPNB gene.

GPI transamidase component PIG-S is an enzyme that in humans is encoded by the PIGS gene. This gene encodes a protein that is involved in GPI-anchor biosynthesis.

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene.

Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene.

Subunit P of phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the PIGP gene.

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H is an enzyme that in humans is encoded by the PIGH gene. The PIGH gene is located on the reverse strand of chromosome 14 in humans, and is neighbored by TMEM229B.

GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene.

Transmembrane protein 229b is a protein that in humans is encoded by the TMEM229b gene.

Phosphatidylinositol glycan anchor biosynthesis, class N is a protein that in humans is encoded by the PIGN gene.

Post-GPI attachment to proteins 1 is a protein that in humans is encoded by the PGAP1 gene.

Myotubularin related protein 12 is a protein that in humans is encoded by the MTMR12 gene.

References

1 2 3 ENSG00000277161 GRCh38: Ensembl release 89: ENSG00000275600, ENSG00000277161 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045140 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Phosphatidylinositol glycan anchor biosynthesis class W" . Retrieved 2016-10-29.

PIGW

Contents

Function

Related Research Articles

References

Further reading