PIK3C2G

PIK3C2G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WWE
Identifiers
Aliases	PIK3C2G , PI3K-C2-gamma, PI3K-C2GAMMA, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
External IDs	OMIM: 609001; MGI: 1203730; HomoloGene: 3362; GeneCards: PIK3C2G; OMA:PIK3C2G - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p12.3 Start 18,242,961 bp [1] End 18,648,416 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 G2|6 69.7 cM Start 139,564,219 bp [2] End 139,915,010 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis hair follicle skin of thigh testicle skin of abdomen right lobe of liver gallbladder stomach body of stomach seminal vesicula Top expressed in morula right kidney stomach epithelium of stomach outer nuclear layer proximal tubule genital tubercle spermatid liver skin of external ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding transferase activity kinase activity phosphatidylinositol phosphate kinase activity phosphatidylinositol binding 1-phosphatidylinositol-3-kinase activity ATP binding 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol 3-kinase activity Cellular component cytosol membrane plasma membrane phosphatidylinositol 3-kinase complex cytoplasm Biological process phosphatidylinositol-mediated signaling phosphatidylinositol phosphate biosynthetic process chemotaxis phosphorylation phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol 3-kinase signaling cell migration phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5288 18705 Ensembl ENSG00000139144 ENSMUSG00000030228 UniProt O75747 O70167 RefSeq (mRNA) NM_001288772 NM_001288774 NM_004570 NM_011084 NM_207683 RefSeq (protein) NP_001275701 NP_001275703 NP_004561 NP_035214 NP_997566 Location (UCSC) Chr 12: 18.24 – 18.65 Mb Chr 6: 139.56 – 139.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene. ^{[5] [6]}

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000139144 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030228 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rozycka M, Lu YJ, Brown RA, Lau MR, Shipley JM, Fry MJ (Feb 1999). "cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12". Genomics. 54 (3): 569–74. doi:10.1006/geno.1998.5621. PMID   9878262.
6. "Entrez Gene: PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide".

Further reading

• Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi: 10.1189/jlb.0503206 . PMID   12960231. S2CID   11362623.
• Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. doi: 10.1074/jbc.271.38.22961 . PMID   8798481.
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID   9341793. S2CID   33397908.
• Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. doi:10.1002/eji.1830271110. PMID   9394803. S2CID   6303471.
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. doi:10.1006/bbrc.1997.7877. PMID   9446795.
• Misawa H, Ohtsubo M, Copeland NG, et al. (1998). "Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain". Biochem. Biophys. Res. Commun. 244 (2): 531–9. doi:10.1006/bbrc.1998.8294. PMID   9514948.
• Ono F, Nakagawa T, Saito S, et al. (1998). "A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration". J. Biol. Chem. 273 (13): 7731–6. doi: 10.1074/jbc.273.13.7731 . PMID   9516481.
• Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. doi: 10.1097/00002030-199811000-00008 . PMID   9708406. S2CID   25758704.
• Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. doi: 10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A . PMID   9808187.
• Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. doi: 10.1182/blood.V97.2.352 . PMID   11154208.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi: 10.1096/fj.00-0354com . PMID   11156964. S2CID   26315564.
• Deregibus MC, Cantaluppi V, Doublier S, et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells". J. Biol. Chem. 277 (28): 25195–202. doi: 10.1074/jbc.M200921200 . PMID   11994280.
• Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism". J. Immunol. 169 (1): 254–60. doi: 10.4049/jimmunol.169.1.254 . PMID   12077252.
• François F, Klotman ME (2003). "Phosphatidylinositol 3-Kinase Regulates Human Immunodeficiency Virus Type 1 Replication following Viral Entry in Primary CD4+ T Lymphocytes and Macrophages". J. Virol. 77 (4): 2539–49. doi:10.1128/JVI.77.4.2539-2549.2003. PMC   141101 . PMID   12551992.
• Khan NA, Di Cello F, Nath A, Kim KS (2004). "Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells". J. Neurovirol. 9 (6): 584–93. doi:10.1080/jnv.9.6.584.593. PMID   14602571.
• Langford D, Hurford R, Hashimoto M, et al. (2006). "Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120". BMC Neuroscience. 6: 8. doi: 10.1186/1471-2202-6-8 . PMC   549045 . PMID   15689238.
• Lee C, Tomkowicz B, Freedman BD, Collman RG (2006). "HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways". J. Leukoc. Biol. 78 (4): 1016–23. doi: 10.1189/jlb.0105056 . PMID   16081599. S2CID   7628860.
• Anand AR, Ganju RK (2006). "HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45". J. Biol. Chem. 281 (18): 12289–99. doi: 10.1074/jbc.M511786200 . PMID   16524887.