PIWIL1

PIWIL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L5C, 2L5D, 3O3I, 3O6E, 3O7V
Identifiers
Aliases	PIWIL1 , CT80.1, HIWI, MIWI, PIWI, piwi like RNA-mediated gene silencing 1
External IDs	OMIM: 605571 MGI: 1928897 HomoloGene: 37963 GeneCards: PIWIL1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	130,372,637 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	128,755,474 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein kinase binding ; • RNA binding ; • single-stranded RNA binding ; • nucleic acid binding ; • GO:0001948 protein binding ; • mRNA binding ; • nuclease activity ; • endonuclease activity ; • endoribonuclease activity ; • hydrolase activity ; • metal ion binding ; • piRNA binding ; • GO:0032403 protein-containing complex binding ; • polysome binding ; • mRNA cap binding complex binding ;
Cellular component	• polysome ; • nucleus ; • mRNA cap binding complex ; • dense body ; • P granule ; • cytoplasm ; • chromatoid body ;
Biological process	• multicellular organism development ; • regulation of translation ; • GO:0007126 meiotic cell cycle ; • cell differentiation ; • gene silencing by RNA ; • spermatogenesis ; • negative regulation of transposition ; • piRNA metabolic process ; • nucleic acid phosphodiester bond hydrolysis ; • RNA phosphodiester bond hydrolysis, endonucleolytic ; • spermatid development ; • spermatogenesis, exchange of chromosomal proteins ;
	Sources:Amigo / QuickGO
Orthologs
	9271
	57749
	ENSG00000275051 ; ENSG00000125207
	ENSMUSG00000029423
	Q96J94
	Q9JMB7
	NM_001190971 ; NM_004764
	NM_021311
	NP_001177900 ; NP_004755
	NP_067286
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 13, 2021

Piwi-like protein 1 is a protein that in humans is encoded by the PIWIL1 gene.^[5]^[6]^[7]

This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms.

The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.^[7]

Related Research Articles

Piwi genes were identified as regulatory proteins responsible for stem cell and germ cell differentiation. Piwi is an abbreviation of P-elementInduced WImpy testis in Drosophila. Piwi proteins are highly conserved RNA-binding proteins and are present in both plants and animals. Piwi proteins belong to the Argonaute/Piwi family and have been classified as nuclear proteins. Studies on Drosophila have also indicated that Piwi proteins have slicer activity conferred by the presence of the Piwi domain. In addition, Piwi associates with heterochromatin protein 1, an epigenetic modifier, and piRNA-complementary sequences. These are indications of the role Piwi plays in epigenetic regulation. Piwi proteins are also thought to control the biogenesis of piRNA as many Piwi-like proteins contain slicer activity which would allow Piwi proteins to process precursor piRNA into mature piRNA.

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Protein FAM60A is a protein that in humans is encoded by the FAM60A gene. The expression of FAM60A gene is higher in KRAS mutant non-small cell lung cancer.

Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.

Serine/threonine-protein kinase WNK2 is an enzyme that in humans is encoded by the WNK2 gene.

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References

1 2 3 ENSG00000125207 GRCh38: Ensembl release 89: ENSG00000275051, ENSG00000125207 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029423 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Cox DN, Chao A, Baker J, Chang L, Qiao D, Lin H (Jan 1999). "A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal". Genes Dev. 12 (23): 3715–27. doi:10.1101/gad.12.23.3715. PMC 317255 . PMID 9851978.
↑ Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics. 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.
1 2 "Entrez Gene: PIWIL1 piwi-like 1 (Drosophila)".

Sharma AK, Nelson MC, Brandt JE, et al. (2001). "Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi". Blood. 97 (2): 426–34. doi: 10.1182/blood.V97.2.426 . PMID 11154219.
Qiao D, Zeeman AM, Deng W, et al. (2002). "Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas". Oncogene. 21 (25): 3988–99. doi: 10.1038/sj.onc.1205505 . PMID 12037681.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Tahbaz N, Kolb FA, Zhang H, et al. (2004). "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer". EMBO Rep. 5 (2): 189–94. doi:10.1038/sj.embor.7400070. PMC 1298981 . PMID 14749716.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Liu X, Sun Y, Guo J, et al. (2006). "Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells". Int. J. Cancer. 118 (8): 1922–9. doi: 10.1002/ijc.21575 . PMID 16287078. S2CID 8616640.
Taubert H, Greither T, Kaushal D, et al. (2007). "Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma". Oncogene. 26 (7): 1098–100. doi: 10.1038/sj.onc.1209880 . PMID 16953229.
Sugimoto K, Kage H, Aki N, et al. (2007). "The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus". Biochem. Biophys. Res. Commun. 359 (3): 497–502. doi:10.1016/j.bbrc.2007.05.136. PMID 17544373.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000125207 GRCh38: Ensembl release 89: ENSG00000275051, ENSG00000125207 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029423 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9851978-5] Cox DN, Chao A, Baker J, Chang L, Qiao D, Lin H (Jan 1999). "A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal". Genes Dev. 12 (23): 3715–27. doi:10.1101/gad.12.23.3715. PMC 317255 . PMID 9851978.

[pmid12906857-6] Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics. 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.

[entrez-7] 1 2 "Entrez Gene: PIWIL1 piwi-like 1 (Drosophila)".

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PIWIL1

Related Research Articles

References

Further reading