PKIG

PKIG
Identifiers
Aliases	PKIG , PKI-gamma, protein kinase (cAMP-dependent, catalytic) inhibitor gamma, cAMP-dependent protein kinase inhibitor gamma
External IDs	OMIM: 604932 MGI: 1343086 HomoloGene: 5133 GeneCards: PKIG
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 44,531,785 bp [1] End 44,624,247 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 H3|2 84.4 cM Start 163,500,306 bp [2] End 163,568,078 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery right ventricle left coronary artery left ventricle myocardium vena cava gastric mucosa saphenous vein right lung left uterine tube Top expressed in otic placode saccule aortic valve endocardial cushion atrioventricular valve ascending aorta renal corpuscle Paneth cell right ventricle ureter More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase inhibitor activity cAMP-dependent protein kinase inhibitor activity Cellular component cytoplasm nucleus Biological process negative regulation of transcription by RNA polymerase II negative regulation of cAMP-dependent protein kinase activity signal transduction negative regulation of protein kinase activity negative regulation of protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11142 18769 Ensembl ENSG00000168734 ENSMUSG00000035268 UniProt Q9Y2B9 O70139 RefSeq (mRNA) NM_181805 NM_001281444 NM_001281445 NM_007066 NM_181804 NM_001039390 NM_001039391 NM_001164053 NM_001164055 NM_001277096 NM_011106 RefSeq (protein) NP_001268373 NP_001268374 NP_008997 NP_861520 NP_861521 NP_001034479 NP_001034480 NP_001157525 NP_001157527 NP_001264025 NP_035236 Location (UCSC) Chr 20: 44.53 – 44.62 Mb Chr 2: 163.5 – 163.57 Mb PubMed search [3] [4]
Wikidata
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cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene. ^{[5] [6]}

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000168734 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035268 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC   1221161 . PMID   10880337.
6. "Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma".

Further reading

• Collins SP, Uhler MD (1997). "Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase". J. Biol. Chem. 272 (29): 18169–78. doi: 10.1074/jbc.272.29.18169 . PMID   9218452.
• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID   11549316.
• Lum H, Hao Z, Gayle D, et al. (2002). "Vascular endothelial cells express isoforms of protein kinase A inhibitor". Am. J. Physiol., Cell Physiol. 282 (1): C59–66. doi:10.1152/ajpcell.00256.2001. PMID   11742798.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID   11978406.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhao L, Yang S, Zhou GQ, et al. (2006). "Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation". Int. J. Biochem. Cell Biol. 38 (12): 2064–73. doi:10.1016/j.biocel.2006.05.015. PMID   16870489.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.