PLA2G10

PLA2G10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LE6, 1LE7, 4UY1
Identifiers
Aliases	PLA2G10 , GXPLA2, GXSPLA2, SPLA2, sPLA2-X, phospholipase A2 group X
External IDs	OMIM: 603603; MGI: 1347522; HomoloGene: 2636; GeneCards: PLA2G10; OMA:PLA2G10 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.12 Start 14,672,548 bp [1] End 14,694,308 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 A1|16 9.5 cM Start 13,532,921 bp [2] End 13,548,847 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum olfactory zone of nasal mucosa testicle duodenum right uterine tube right lung body of stomach body of pancreas upper lobe of left lung Top expressed in epithelium of stomach mucous cell of stomach left colon pyloric antrum spermatid seminiferous tubule Ileal epithelium embryo morula blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding phospholipase A2 activity phospholipase activity metal ion binding hydrolase activity phospholipid binding calcium-dependent phospholipase A2 activity Cellular component extracellular region extracellular space Biological process phosphatidic acid biosynthetic process positive regulation of protein metabolic process phosphatidylserine acyl-chain remodeling phosphatidylethanolamine acyl-chain remodeling lysophospholipid transport lipid metabolism positive regulation of lipid storage phosphatidylinositol acyl-chain remodeling negative regulation of DNA-binding transcription factor activity axon guidance lipid catabolic process positive regulation of prostaglandin secretion positive regulation of macrophage derived foam cell differentiation positive regulation of arachidonic acid secretion phosphatidylglycerol acyl-chain remodeling negative regulation of cholesterol efflux cholesterol homeostasis arachidonic acid metabolic process phosphatidylcholine acyl-chain remodeling regulation of macrophage activation phospholipid metabolic process arachidonic acid secretion cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8399 26565 Ensembl ENSG00000276870 ENSG00000069764 ENSMUSG00000022683 UniProt O15496 Q9QXX3 RefSeq (mRNA) NM_003561 NM_001291009 NM_011987 RefSeq (protein) NP_003552 NP_001277938 NP_036117 Location (UCSC) Chr 16: 14.67 – 14.69 Mb Chr 16: 13.53 – 13.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Group 10 secretory phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G10 gene. ^{[5] [6]}

See also

• Phospholipase A₂

References

1. ENSG00000069764 GRCh38: Ensembl release 89: ENSG00000276870, ENSG00000069764 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022683 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cupillard L, Koumanov K, Mattei MG, Lazdunski M, Lambeau G (Jul 1997). "Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2". J Biol Chem. 272 (25): 15745–52. doi: 10.1074/jbc.272.25.15745 . PMID   9188469.
6. "Entrez Gene: PLA2G10 phospholipase A2, group X".

Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID   9745929.
• Sartipy P, Camejo G, Svensson L, Hurt-Camejo E (2002). "Phospholipase A2 Modification of Lipoproteins: Potential Effects on Atherogenesis". Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology. Vol. 507. pp. 3–7. doi:10.1007/978-1-4615-0193-0_1. ISBN   978-1-4613-4960-0. PMID   12664556.
• Murakami M, Kudo I (2004). "New phospholipase A(2) isozymes with a potential role in atherosclerosis". Curr. Opin. Lipidol. 14 (5): 431–6. doi:10.1097/00041433-200310000-00003. PMID   14501581. S2CID   28202085.
• Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics. 33 (1): 151–2. doi: 10.1006/geno.1996.0177 . PMID   8617505.
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi: 10.1097/00042560-199709010-00001 . PMID   9377118.
• Yokota Y, Higashino K, Nakano K, et al. (2000). "Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor". FEBS Lett. 478 (1–2): 187–91. doi: 10.1016/S0014-5793(00)01848-2 . PMID   10922494. S2CID   28188560.
• Morioka Y, Saiga A, Yokota Y, et al. (2000). "Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor". Arch. Biochem. Biophys. 381 (1): 31–42. doi:10.1006/abbi.2000.1977. PMID   11019817.
• Degousee N, Ghomashchi F, Stefanski E, et al. (2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis". J. Biol. Chem. 277 (7): 5061–73. doi: 10.1074/jbc.M109083200 . PMID   11741884.
• Hanasaki K, Yamada K, Yamamoto S, et al. (2002). "Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation". J. Biol. Chem. 277 (32): 29116–24. doi: 10.1074/jbc.M202867200 . PMID   12021277.
• Osterström A, Dimberg J, Fransén K, Söderkvist P (2002). "Expression of cytosolic and group X secretory phospholipase A(2) genes in human colorectal adenocarcinomas". Cancer Lett. 182 (2): 175–82. doi:10.1016/S0304-3835(02)00081-2. PMID   12048163.
• Pan YH, Yu BZ, Singer AG, et al. (2002). "Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes". J. Biol. Chem. 277 (32): 29086–93. doi: 10.1074/jbc.M202531200 . PMID   12161451.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wooton-Kee CR, Boyanovsky BB, Nasser MS, et al. (2004). "Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation". Arterioscler. Thromb. Vasc. Biol. 24 (4): 762–7. CiteSeerX   10.1.1.496.1425 . doi: 10.1161/01.ATV.0000122363.02961.c1 . PMID   14962950.
• Mounier CM, Ghomashchi F, Lindsay MR, et al. (2004). "Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha" (PDF). J. Biol. Chem. 279 (24): 25024–38. doi: 10.1074/jbc.M313019200 . PMID   15007070. S2CID   19214808.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Masuda S, Murakami M, Takanezawa Y, et al. (2005). "Neuronal expression and neuritogenic action of group X secreted phospholipase A2". J. Biol. Chem. 280 (24): 23203–14. doi: 10.1074/jbc.M500985200 . PMID   15781456.