PLA2G4E (gene)

PLA2G4E
Identifiers
Aliases	PLA2G4E , phospholipase A2 group IVE
External IDs	MGI: 1919144 HomoloGene: 65339 GeneCards: PLA2G4E
Gene location (Human)
Chr.	Chromosome 15 (human)
End	42,051,190 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	120,075,816 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; thymus; ; vagina; ; skeletal muscle tissue; ; muscle of leg; ; gastrocnemius muscle; ; islet of Langerhans; ; minor salivary gland; ; endometrium; ; upper lobe of left lung;
	Top expressed in
	lip; ; knee joint; ; esophagus; ; quadriceps femoris muscle; ; soleus muscle; ; skeletal muscle tissue; ; gastrocnemius muscle; ; temporal muscle; ; triceps brachii muscle; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity ; phospholipase activity ; metal ion binding ; phospholipase A2 activity ; phospholipase A1 activity ; lysophospholipase activity ; calcium ion binding ; calcium-dependent phospholipid binding ; calcium-dependent phospholipase A2 activity ;
Cellular component	lysosomal membrane ; cytosol ; cytoplasm ; lysosome ; membrane ;
Biological process	lipid metabolism ; lipid catabolic process ; metabolism ; phosphatidylserine acyl-chain remodeling ; phosphatidylethanolamine acyl-chain remodeling ; phospholipid metabolic process ; phosphatidylcholine acyl-chain remodeling ; phospholipid catabolic process ; phosphatidylinositol acyl-chain remodeling ; glycerophospholipid catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	123745
	329502
	ENSG00000188089
	ENSMUSG00000050211
	Q3MJ16
	Q50L42
	NM_001080490 ; NM_001206670 ; NM_001395548 ; NM_198442
	NM_177845 ; NM_001363090 ; NM_001363091 ; NM_001395470
	NP_001193599
	NP_808513 ; NP_001350019 ; NP_001350020 ; NP_001382399
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 01, 2023

Phospholipase A2 group IVE is a protein that in humans is encoded by the PLA2G4E gene. ^[5]

Function

This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017].

Related Research Articles

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Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene. It is a member of the peroxiredoxin family of antioxidant enzymes.

Group IID secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G2D gene.

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA gene.

LYPLA3, also known as Group XV phospholipase A2, is an enzyme that in humans is encoded by the PLA2G15 gene.

Calcium-independent phospholipase A2-gamma is an enzyme that in humans is encoded by the PNPLA8 gene.

Patatin-like phospholipase domain-containing protein 3 (PNPLA3) also known as adiponutrin (ADPN), acylglycerol O-acyltransferase or calcium-independent phospholipase A2-epsilon (iPLA2-epsilon) is an enzyme that in humans is encoded by the PNPLA3 gene.

Group XIIA secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G12A gene.

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.

Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene.

Dual specificity protein phosphatase 23, also known as low molecular mass dual specificity phosphatase 3 (LDP-3), is an enzyme that in humans is encoded by the DUSP23 gene.

FERM and PDZ domain containing 4 is a protein that in humans is encoded by the FRMPD4 gene.

WD repeat containing planar cell polarity effector is a protein that in humans is encoded by the WDPCP gene.

Cell growth regulator with EF-hand domain 1 is a protein that in humans is encoded by the CGREF1 gene.

Phospholipase A2 group IVD is a protein that in humans is encoded by the PLA2G4D gene.

Solute carrier family 39 member 11 is a protein that in humans is encoded by the SLC39A11 gene.

Sterile alpha motif domain containing 4A is a protein that in humans is encoded by the SAMD4A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188089 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050211 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Phospholipase A2 group IVE" . Retrieved 2018-06-13.

PLA2G4E (gene)

Contents

Function

Related Research Articles

References

Further reading