PLA2G5

PLA2G5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GHN
Identifiers
Aliases	PLA2G5 , FRFB, GV-PLA2, PLA2-10, hVPLA(2), phospholipase A2 group V
External IDs	OMIM: 601192; MGI: 101899; HomoloGene: 716; GeneCards: PLA2G5; OMA:PLA2G5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,091,911 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,590,793 bp
RNA expression pattern
	Top expressed in
	right auricle; ; apex of heart; ; right coronary artery; ; left ventricle; ; left ovary; ; right ovary; ; left coronary artery; ; right ventricle; ; cardiac muscle tissue of right atrium; ; retinal pigment epithelium;
	Top expressed in
	Basal plate; ; neural layer of retina; ; molar; ; epithelium of lens; ; vestibular membrane of cochlear duct; ; intercostal muscle; ; retinal pigment epithelium; ; iris; ; trachea; ; utricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding ; heparin binding ; calcium-dependent phospholipase A2 activity ; metal ion binding ; hydrolase activity ; phospholipase A2 activity ; phospholipid binding ;
Cellular component	Golgi apparatus ; plasma membrane ; extracellular region ; perinuclear region of cytoplasm ; cell surface ;
Biological process	phosphatidic acid biosynthetic process ; response to cytokine ; phosphatidylserine acyl-chain remodeling ; phosphatidylethanolamine acyl-chain remodeling ; lipid metabolism ; platelet activating factor biosynthetic process ; phosphatidylinositol acyl-chain remodeling ; lipid catabolic process ; positive regulation of phospholipase activity ; phosphatidylglycerol acyl-chain remodeling ; positive regulation of ERK1 and ERK2 cascade ; response to cAMP ; leukotriene biosynthetic process ; phosphatidylcholine acyl-chain remodeling ; arachidonic acid secretion ; phospholipid metabolic process ; low-density lipoprotein particle remodeling ; regulation of macrophage activation ; negative regulation of inflammatory response ;
	Sources:Amigo / QuickGO
Orthologs
	5322
	18784
	ENSG00000127472
	ENSMUSG00000041193
	P39877
	P97391
	NM_000929
	NM_001122954 ; NM_011110
	NP_000920
	NP_001116426 ; NP_035240
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 21, 2024

Calcium-dependent phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G5 gene.^[5]^[6]^[7]

This gene is a member of the secretory phospholipase A₂ family. It is located in a tightly-linked cluster of secretory phospholipase A₂ genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.^[7]

^[8]

Related Research Articles

Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Phospholipase A₂, membrane associated is an enzyme that in humans is encoded by the PLA2G2A gene.

Cytosolic phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G4A gene.

Phospholipase A₂, group 1B is an enzyme that in humans is encoded by the PLA2G1B gene.

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 is an enzyme that in humans is encoded by the PLCD1 gene. PLCd1 is essential to maintain homeostasis of the skin.

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.

Cytosolic phospholipase A₂ gamma is an enzyme that in humans is encoded by the PLA2G4C gene.

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.

Group 10 secretory phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G10 gene.

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4 is an enzyme that in humans is encoded by the PLCD4 gene.

Group IID secretory phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G2D gene.

Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene.

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA gene.

LYPLA3, also known as Group XV phospholipase A2, is an enzyme that in humans is encoded by the PLA2G15 gene.

Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.

Phospholipase A₂, group IVB (cytosolic) is an enzyme that in humans is encoded by the PLA2G4B gene.

Group XIIA secretory phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G12A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000127472 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041193 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tischfield JA, Xia YR, Shih DM, Klisak I, Chen J, Engle SJ, Siakotos AN, Winstead MV, Seilhamer JJ, Allamand V, Gyapay G, Lusis AJ (February 1997). "Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human". Genomics. 32 (3): 328–33. doi:10.1006/geno.1996.0126. PMID 8838795.
↑ Chen J, Engle SJ, Seilhamer JJ, Tischfield JA (March 1994). "Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2". J Biol Chem. 269 (4): 2365–8. doi: 10.1016/S0021-9258(17)41952-1 . PMID 8300559.
1 2 "Entrez Gene: PLA2G5 phospholipase A2, group V".
↑ Otha, Shin (15 June 2013). "Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation". Journal of Immunology. 12 (190): 5927–38. doi:10.4049/jimmunol.1203202. PMC 3939699 . PMID 23650617.

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
Cho W (2001). "Structure, function, and regulation of group V phospholipase A(2)". Biochim. Biophys. Acta. 1488 (1–2): 48–58. doi:10.1016/s1388-1981(00)00109-8. PMID 11080676.
de Beer FC, Webb NR (2006). "Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant". Arterioscler. Thromb. Vasc. Biol. 26 (7): 1421–2. doi: 10.1161/01.ATV.0000227561.89488.9a . PMID 16794232.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi: 10.1097/00042560-199709010-00001 . PMID 9377118.
Chen Y, Dennis EA (1998). "Expression and characterization of human group V phospholipase A2". Biochim. Biophys. Acta. 1394 (1): 57–64. doi:10.1016/s0005-2760(98)00098-8. PMID 9767110.
Bingham CO, Fijneman RJ, Friend DS, et al. (1999). "Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells". J. Biol. Chem. 274 (44): 31476–84. doi: 10.1074/jbc.274.44.31476 . PMID 10531350.
Johansen B, Rakkestad K, Balboa MA, Dennis EA (2000). "Expression of cytosolic and secreted forms of phospholipase A(2) and cyclooxygenases in human placenta, fetal membranes, and chorionic cell lines". Prostaglandins Other Lipid Mediat. 60 (4–6): 119–25. doi:10.1016/S0090-6980(99)00057-X. PMID 10751642.
Kim KP, Han SK, Hong M, Cho W (2000). "The molecular basis of phosphatidylcholine preference of human group-V phospholipase A2". Biochem. J. 348. Pt 3 (3): 643–7. doi:10.1042/0264-6021:3480643. PMC 1221108 . PMID 10839997.
Seeds MC, Jones KA, Duncan Hite R, et al. (2000). "Cell-specific expression of group X and group V secretory phospholipases A(2) in human lung airway epithelial cells". Am. J. Respir. Cell Mol. Biol. 23 (1): 37–44. doi:10.1165/ajrcmb.23.1.4034. PMID 10873151.
Bernatchez PN, Winstead MV, Dennis EA, Sirois MG (2001). "VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2". Br. J. Pharmacol. 134 (1): 197–205. doi:10.1038/sj.bjp.0704215. PMC 1572915 . PMID 11522612.
Degousee N, Ghomashchi F, Stefanski E, et al. (2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis". J. Biol. Chem. 277 (7): 5061–73. doi: 10.1074/jbc.M109083200 . PMID 11741884.
Kim YJ, Kim KP, Han SK, et al. (2002). "Group V phospholipase A2 induces leukotriene biosynthesis in human neutrophils through the activation of group IVA phospholipase A2". J. Biol. Chem. 277 (39): 36479–88. doi: 10.1074/jbc.M205399200 . PMID 12124392.
Hichami A, Joshi B, Simonin AM, Khan NA (2003). "Role of three isoforms of phospholipase A2 in capacitative calcium influx in human T-cells". Eur. J. Biochem. 269 (22): 5557–63. doi: 10.1046/j.1432-1033.2002.03261.x . PMID 12423354.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Muñoz NM, Kim YJ, Meliton AY, et al. (2003). "Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils". J. Biol. Chem. 278 (40): 38813–20. doi: 10.1074/jbc.M302476200 . PMID 12796497.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000127472 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041193 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8838795-5] Tischfield JA, Xia YR, Shih DM, Klisak I, Chen J, Engle SJ, Siakotos AN, Winstead MV, Seilhamer JJ, Allamand V, Gyapay G, Lusis AJ (February 1997). "Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human". Genomics. 32 (3): 328–33. doi:10.1006/geno.1996.0126. PMID 8838795.

[pmid8300559-6] Chen J, Engle SJ, Seilhamer JJ, Tischfield JA (March 1994). "Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2". J Biol Chem. 269 (4): 2365–8. doi: 10.1016/S0021-9258(17)41952-1 . PMID 8300559.

[entrez-7] 1 2 "Entrez Gene: PLA2G5 phospholipase A2, group V".

[8] Otha, Shin (15 June 2013). "Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation". Journal of Immunology. 12 (190): 5927–38. doi:10.4049/jimmunol.1203202. PMC 3939699 . PMID 23650617.

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PLA2G5

Related Research Articles

References

Further reading