PLAGL2

PLAGL2
Identifiers
Aliases	PLAGL2 , ZNF900, PLAG1 like zinc finger 2
External IDs	OMIM: 604866 MGI: 1933165 HomoloGene: 1994 GeneCards: PLAGL2
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q11.21 Start 32,192,504 bp [1] End 32,207,743 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H1 Start 153,069,679 bp [2] End 153,083,346 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm monocyte secondary oocyte amniotic fluid pancreatic ductal cell bone marrow cells ganglionic eminence rectum blood body of stomach Top expressed in mirror maxillary prominence ileum inner renal medulla endocardial cushion somite external carotid artery ureter hand internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA binding nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated chylomicron assembly positive regulation of transcription by RNA polymerase II transcription, DNA-templated lipid metabolism positive regulation of intrinsic apoptotic signaling pathway post-embryonic development transcription by RNA polymerase II apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5326 54711 Ensembl ENSG00000126003 ENSMUSG00000051413 UniProt Q9UPG8 Q925T4 RefSeq (mRNA) NM_002657 NM_018807 RefSeq (protein) NP_002648 NP_061277 Location (UCSC) Chr 20: 32.19 – 32.21 Mb Chr 2: 153.07 – 153.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein PLAGL2 is a protein that in humans is encoded by the PLAGL2 gene. ^{[5] [6] [7]}

Zinc finger protein PLAGL2 is a zinc finger protein that recognizes DNA and/or RNA. ^[7]

The gene has seen in gliomas to suppress cellular differentiation and thus encourage cells to become more stem cell like. Such plasticity is seen in glioma cells, together with the ignorance to differentiation factors. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000126003 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051413 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH (Mar 2005). "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11". Blood. 105 (7): 2900–7. doi: 10.1182/blood-2004-09-3630 . PMID   15585652.
6. Zheng G, Ning J, Yang YC (Oct 2007). "PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53". Biochem Biophys Res Commun. 364 (2): 344–50. doi:10.1016/j.bbrc.2007.10.003. PMC   2708094 . PMID   17950244.
7. "Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2".
8. Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA (May 2010). "PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma". Cancer Cell. 17 (5): 497–509. doi:10.1016/j.ccr.2010.03.020. PMC   2900858 . PMID   20478531.

Further reading

• Guo Y, Yang MC, Weissler JC, Yang YS (2007). "PLAGL2 Translocation and SP-C Promoter Activity – A Cellular Response of Lung Cells to Hypoxia". Biochem. Biophys. Res. Commun. 360 (3): 659–65. doi:10.1016/j.bbrc.2007.06.106. PMC   2084061 . PMID   17618602.
• Ammons MC, Siemsen DW, Nelson-Overton LK, et al. (2007). "Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 promoter regulates p67(phox) expression and NADPH oxidase activity". J. Biol. Chem. 282 (24): 17941–52. doi: 10.1074/jbc.M610618200 . PMID   17462995.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yang MC, Weissler JC, Terada LS, et al. (2005). "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter". Am. J. Respir. Cell Mol. Biol. 32 (1): 35–43. CiteSeerX   10.1.1.325.6715 . doi:10.1165/rcmb.2003-0422OC. PMID   15361364.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Furukawa T, Adachi Y, Fujisawa J, et al. (2001). "Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines". Oncogene. 20 (34): 4718–27. doi: 10.1038/sj.onc.1204647 . PMID   11498794.
• Kas K, Voz ML, Hensen K, et al. (1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi: 10.1074/jbc.273.36.23026 . PMID   9722527.
• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi: 10.1093/dnares/3.1.17 . PMID   8724849.