PLEKHB2

PLEKHB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AJ4, 3VIA
Identifiers
Aliases	PLEKHB2 , EVT2, pleckstrin homology domain containing B2
External IDs	OMIM: 618452; MGI: 2385825; HomoloGene: 9938; GeneCards: PLEKHB2; OMA:PLEKHB2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q21.1 Start 131,104,847 bp [1] End 131,353,709 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 B Start 34,889,057 bp [2] End 34,918,661 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons endothelial cell superior vestibular nucleus inferior ganglion of vagus nerve pars compacta Brodmann area 23 cerebellar vermis spinal ganglia lateral nuclear group of thalamus pars reticulata Top expressed in choroid plexus of fourth ventricle medulla oblongata superior colliculus medial vestibular nucleus entorhinal cortex perirhinal cortex neural layer of retina pyloric antrum dorsal tegmental nucleus right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphatidylinositol-3,4,5-trisphosphate binding Cellular component membrane recycling endosome membrane endosome integral component of membrane Biological process regulation of cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55041 226971 Ensembl ENSG00000115762 ENSMUSG00000026123 UniProt Q96CS7 Q9QZC7 RefSeq (mRNA) NM_001031706 NM_001100623 NM_001267062 NM_001267063 NM_001267064 NM_001267065 NM_001267066 NM_001267067 NM_001267068 NM_001309448 NM_001309450 NM_001309451 NM_001309452 NM_017958 NM_145516 NM_175421 NM_001357425 RefSeq (protein) NP_001094093 NP_001253991 NP_001253992 NP_001253993 NP_001253994 NP_001253995 NP_001253996 NP_001253997 NP_001296377 NP_001296379 NP_001296380 NP_001296381 NP_060428 NP_001094093.1 NP_663491 NP_780630 NP_001344354 Location (UCSC) Chr 2: 131.1 – 131.35 Mb Chr 1: 34.89 – 34.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pleckstrin homology domain-containing family B member 2 is a protein that in humans is encoded by the PLEKHB2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000115762 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026123 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Krappa R, Nguyen A, Burrola P, Deretic D, Lemke G (May 1999). "Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes". Proc Natl Acad Sci U S A. 96 (8): 4633–8. Bibcode:1999PNAS...96.4633K. doi: 10.1073/pnas.96.8.4633 . PMC   16384 . PMID   10200314.
6. "Entrez Gene: PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC   1221362 . PMID   11001876.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.