PLEKHB2

PLEKHB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3AJ4, 3VIA
Identifiers
Aliases	PLEKHB2 , EVT2, pleckstrin homology domain containing B2
External IDs	OMIM: 618452 MGI: 2385825 HomoloGene: 9938 GeneCards: PLEKHB2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	131,353,709 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	34,918,661 bp
RNA expression pattern
	Top expressed in
	pons; ; endothelial cell; ; superior vestibular nucleus; ; inferior ganglion of vagus nerve; ; Brodmann area 23; ; cerebellar vermis; ; spinal ganglia; ; palpebral conjunctiva; ; ventral tegmental area; ; renal medulla;
	Top expressed in
	medulla oblongata; ; superior colliculus; ; medial vestibular nucleus; ; entorhinal cortex; ; pyloric antrum; ; dorsal tegmental nucleus; ; paraventricular nucleus of hypothalamus; ; inferior colliculus; ; pontine nuclei; ; arcuate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; phosphatidylinositol-3,4,5-trisphosphate binding ;
Cellular component	membrane ; recycling endosome membrane ; endosome ; integral component of membrane ;
Biological process	regulation of cell differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	55041
	226971
	ENSG00000115762
	ENSMUSG00000026123
	Q96CS7
	Q9QZC7
NM_001031706 ; NM_001100623 ; NM_001267062 ; NM_001267063 ; NM_001267064 ;
	NM_001267065 ; NM_001267066 ; NM_001267067 ; NM_001267068 ; NM_001309448 ; NM_001309450 ; NM_001309451 ; NM_001309452 ; NM_017958
	NM_145516 ; NM_175421 ; NM_001357425
NP_001094093 ; NP_001253991 ; NP_001253992 ; NP_001253993 ; NP_001253994 ;
	NP_001253995 ; NP_001253996 ; NP_001253997 ; NP_001296377 ; NP_001296379 ; NP_001296380 ; NP_001296381 ; NP_060428 ; NP_001094093.1
	NP_663491 ; NP_780630 ; NP_001344354
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Pleckstrin homology domain-containing family B member 2 is a protein that in humans is encoded by the PLEKHB2 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115762 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026123 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Krappa R, Nguyen A, Burrola P, Deretic D, Lemke G (May 1999). "Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes". Proc Natl Acad Sci U S A. 96 (8): 4633–8. Bibcode:1999PNAS...96.4633K. doi: 10.1073/pnas.96.8.4633 . PMC 16384 . PMID 10200314.
↑ "Entrez Gene: PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dowler S, Currie RA, Campbell DG, et al. (2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362 . PMID 11001876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147 . PMID 15231747.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115762 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026123 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10200314-5] Krappa R, Nguyen A, Burrola P, Deretic D, Lemke G (May 1999). "Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes". Proc Natl Acad Sci U S A. 96 (8): 4633–8. Bibcode:1999PNAS...96.4633K. doi: 10.1073/pnas.96.8.4633 . PMC 16384 . PMID 10200314.

[entrez-6] "Entrez Gene: PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2".

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PLEKHB2

Related Research Articles

References

Further reading