PLP2

PLP2
Identifiers
Aliases	PLP2 , A4, A4LSB, proteolipid protein 2 (colonic epithelium-enriched), proteolipid protein 2
External IDs	OMIM: 300112 MGI: 1298382 HomoloGene: 2003 GeneCards: PLP2
Gene location (Human)
Chr.	X chromosome (human)
End	49,175,235 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	7,537,629 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; right coronary artery; ; ascending aorta; ; nipple; ; popliteal artery; ; body of pancreas; ; human penis; ; vulva; ; vagina; ; left coronary artery;
	Top expressed in
	epidermis; ; cornea; ; corneal stroma; ; lip; ; skin of back; ; white adipose tissue; ; yolk sac; ; stomach; ; upper arm; ; belly cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion transmembrane transporter activity ; protein binding ; chemokine binding ;
Cellular component	membrane ; endoplasmic reticulum membrane ; plasma membrane ; endoplasmic reticulum ; integral component of membrane ;
Biological process	cytokine-mediated signaling pathway ; chemotaxis ; ion transport ; ion transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	5355
	18824
	ENSG00000102007
	ENSMUSG00000031146
	Q04941
	Q9R1Q7
	NM_002668
	NM_019755
	NP_002659 ; NP_002659.1
	NP_062729
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 09, 2023

Proteolipid protein 2 is a protein that in humans is encoded by the PLP2 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102007 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031146 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Oliva MM, Wu TC, Yang VW (May 1993). "Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18". Arch Biochem Biophys. 302 (1): 183–192. doi: 10.1006/abbi.1993.1197 . PMID 8470895.
↑ Oliva MM, Cortese JF, Yang VW (Aug 1995). "Promoter regulation of a differentially expressed gene in the human colonic epithelial cell lines HT29-18 and HT29-18-C1". Gene. 159 (2): 151–157. doi: 10.1016/0378-1119(95)00130-X . PMID 7622043.
↑ "Entrez Gene: PLP2 proteolipid protein 2 (colonic epithelium-enriched)".

Breitwieser GE, McLenithan JC, Cortese JF, et al. (1997). "Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics". Am. J. Physiol. 272 (3 Pt 1): C957–65. doi:10.1152/ajpcell.1997.272.3.C957. PMID 9124532.
Fisher SE, Ciccodicola A, Tanaka K, et al. (1998). "Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp" (PDF). Genomics. 45 (2): 340–347. doi:10.1006/geno.1997.4941. hdl: 11858/00-001M-0000-0012-CBE6-7 . PMID 9344658.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Wang B, Nguyen M, Breckenridge DG, et al. (2003). "Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria". J. Biol. Chem. 278 (16): 14461–14468. doi: 10.1074/jbc.M209684200 . PMID 12529377.
Lee SM, Shin H, Jang SW, et al. (2004). "PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells". Biochem. Biophys. Res. Commun. 324 (2): 768–772. doi:10.1016/j.bbrc.2004.09.118. PMID 15474493.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–208. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
Zhang L, Jie C, Obie C, et al. (2007). "X chromosome cDNA microarray screening identifies a functional PLP2 promoter polymorphism enriched in patients with X-linked mental retardation". Genome Res. 17 (5): 641–648. doi:10.1101/gr.5336307. PMC 1855181 . PMID 17416750.
Stirling PC, Srayko M, Takhar KS, et al. (2007). "Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression". Mol. Biol. Cell. 18 (6): 2336–2345. doi:10.1091/mbc.E07-01-0069. PMC 1877119 . PMID 17429077.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102007 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031146 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8470895-5] Oliva MM, Wu TC, Yang VW (May 1993). "Isolation and characterization of a differentiation-dependent gene in the human colonic cell line HT29-18". Arch Biochem Biophys. 302 (1): 183–192. doi: 10.1006/abbi.1993.1197 . PMID 8470895.

[pmid7622043-6] Oliva MM, Cortese JF, Yang VW (Aug 1995). "Promoter regulation of a differentially expressed gene in the human colonic epithelial cell lines HT29-18 and HT29-18-C1". Gene. 159 (2): 151–157. doi: 10.1016/0378-1119(95)00130-X . PMID 7622043.

[entrez-7] "Entrez Gene: PLP2 proteolipid protein 2 (colonic epithelium-enriched)".

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PLP2

Related Research Articles

References

Further reading