PLSCR4

PLSCR4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3Q5U
Identifiers
Aliases	PLSCR4 , TRA1, phospholipid scramblase 4
External IDs	OMIM: 607612 MGI: 2143267 HomoloGene: 23217 GeneCards: PLSCR4
Gene location (Human)
Chr.	Chromosome 3 (human)
End	146,251,179 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	92,374,509 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; parietal pleura; ; Achilles tendon; ; tibial nerve; ; pericardium; ; visceral pleura; ; ascending aorta; ; synovial joint; ; optic nerve; ; subcutaneous adipose tissue;
	Top expressed in
	sciatic nerve; ; iris; ; carotid body; ; lung; ; left lung lobe; ; right lung; ; esophagus; ; ciliary body; ; adrenal gland; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding ; phospholipid scramblase activity ; enzyme binding ; calcium ion binding ; CD4 receptor binding ; protein binding ;
Cellular component	integral component of membrane ; plasma membrane ; membrane ;
Biological process	cellular response to lipopolysaccharide ; plasma membrane phospholipid scrambling ;
	Sources:Amigo / QuickGO
Orthologs
	57088
	235527
	ENSG00000114698
	ENSMUSG00000032377
	Q9NRQ2
	P58196
	NM_001128304 ; NM_001128305 ; NM_001128306 ; NM_001177304 ; NM_020353 Contents See also ; References ; Further reading ;
	NM_178711
	NP_001121776 ; NP_001121777 ; NP_001121778 ; NP_001170775 ; NP_065086
	NP_848826
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Phospholipid scramblase 4, also known as Ca²⁺-dependent phospholipid scramblase 4, is a protein that is encoded in humans by the PLSCR4 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000114698 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032377 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: phospholipid scramblase 4".
↑ Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (July 2000). "Identification of three new members of the phospholipid scramblase gene family". Biochim. Biophys. Acta. 1467 (1): 244–53. doi: 10.1016/S0005-2736(00)00236-4 . PMID 10930526.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316 . PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Shibata H, Suzuki H, Kakiuchi T, et al. (2008). "Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants". J. Biol. Chem. 283 (15): 9623–32. doi: 10.1074/jbc.M800717200 . PMID 18256029.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Sahu SK, Aradhyam GK, Gummadi SN (2009). "Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell". Biochim. Biophys. Acta. 1790 (10): 1274–81. doi:10.1016/j.bbagen.2009.06.008. PMID 19540310.
Py B, Basmaciogullari S, Bouchet J, et al. (2009). "The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane". PLOS ONE. 4 (3): e5006. Bibcode:2009PLoSO...4.5006P. doi: 10.1371/journal.pone.0005006 . PMC 2659420 . PMID 19333378.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000114698 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032377 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: phospholipid scramblase 4".

[pmid10930526-6] Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (July 2000). "Identification of three new members of the phospholipid scramblase gene family". Biochim. Biophys. Acta. 1467 (1): 244–53. doi: 10.1016/S0005-2736(00)00236-4 . PMID 10930526.

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PLSCR4

Contents

See also

Related Research Articles

References

Further reading