PLXNA2

PLXNA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q3J
Identifiers
Aliases	PLXNA2 , OCT, PLXN2, plexin A2
External IDs	OMIM: 601054 MGI: 107684 HomoloGene: 56427 GeneCards: PLXNA2
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.2 Start 208,022,242 bp [1] End 208,244,384 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H6 Start 194,300,526 bp [2] End 194,499,177 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence body of pancreas right lung upper lobe of left lung postcentral gyrus left coronary artery right coronary artery sural nerve Brodmann area 46 popliteal artery Top expressed in ganglionic eminence medial ganglionic eminence olfactory tubercle hair follicle nucleus accumbens internal carotid artery ventromedial nucleus external carotid artery primary motor cortex subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding semaphorin receptor activity identical protein binding Cellular component integral component of membrane plasma membrane semaphorin receptor complex membrane integral component of plasma membrane Biological process somitogenesis cell surface receptor signaling pathway regulation of axon extension involved in axon guidance cerebellar granule cell precursor tangential migration branchiomotor neuron axon guidance limb bud formation neural tube development semaphorin-plexin signaling pathway signal transduction pharyngeal system development centrosome localization regulation of cell migration negative regulation of cell adhesion regulation of cell shape regulation of GTPase activity positive regulation of axonogenesis semaphorin-plexin signaling pathway involved in axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5362 18845 Ensembl ENSG00000076356 ENSMUSG00000026640 UniProt O75051 P70207 RefSeq (mRNA) NM_025179 NM_008882 RefSeq (protein) NP_079455 NP_032908 Location (UCSC) Chr 1: 208.02 – 208.24 Mb Chr 1: 194.3 – 194.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene. ^{[5] [6]}

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. ^[6]

In some studies, the PLXNA2 gene is associated with schizophrenia. ^[7] and anxiety. PLXNA2 is a candidate gene for intellectual disability and possibly facial dysmorphism and congenital heart disease ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000076356 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026640 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci USA. 93 (2): 674–8. Bibcode:1996PNAS...93..674M. doi: 10.1073/pnas.93.2.674 . PMC   40111 . PMID   8570614.
6. "Entrez Gene: PLXNA2 plexin A2".
7. "Gene Overview of All Published Schizophrenia-Association Studies for PLXNA2". Schizophrenia Research Forum . Archived from the original on 21 February 2009.
8. Altuame FD, Shamseldin HE, Albatti TH, Hashem M, Ewida N, Abdulwahab F, Alkuraya FS (July 2021). "PLXNA2 as a candidate gene in patients with intellectual disability". American Journal of Medical Genetics. Part A. 185 (12): 3859–3865. doi:10.1002/ajmg.a.62440. PMID   34327814. S2CID   236516392.
9. Wray NR, James MR, Mah SP, Nelson M, Andrews G, Sullivan PF, et al. (March 2007). "Anxiety and comorbid measures associated with PLXNA2". Archives of General Psychiatry. 64 (3): 318–26. doi: 10.1001/archpsyc.64.3.318 . PMID   17339520.

Further reading

• Negishi M, Oinuma I, Katoh H (2005). "Plexins: axon guidance and signal transduction". Cell. Mol. Life Sci. 62 (12): 1363–71. doi:10.1007/s00018-005-5018-2. PMID   15818466. S2CID   32299864.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID   9455484.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi: 10.1016/S0092-8674(00)80063-X . PMID   10520995. S2CID   17386412.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Mah S, Nelson MR, Delisi LE, et al. (2006). "Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia". Mol. Psychiatry. 11 (5): 471–8. doi: 10.1038/sj.mp.4001785 . PMID   16402134.
• Fujii T, Iijima Y, Kondo H, et al. (2007). "Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (4): 873–7. doi:10.1016/j.pnpbp.2007.01.027. PMID   17346868. S2CID   46003583.