PLXNB2

PLXNB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4E71
Identifiers
Aliases	PLXNB2 , MM1, Nbla00445, PLEXB2, dJ402G11.3, plexin B2
External IDs	OMIM: 604293 MGI: 2154239 HomoloGene: 66630 GeneCards: PLXNB2
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,307,646 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,064,991 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; anterior pituitary; ; stromal cell of endometrium; ; body of stomach; ; fundus; ; minor salivary gland; ; spleen; ; pylorus;
	Top expressed in
	pyloric antrum; ; calvaria; ; corneal stroma; ; Epithelium of stomach; ; conjunctival fornix; ; lip; ; yolk sac; ; intestinal villus; ; external carotid artery; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; semaphorin receptor activity ;
Cellular component	integral component of membrane ; membrane ; plasma membrane ; cell surface ; extracellular exosome ; integral component of plasma membrane ; semaphorin receptor complex ;
Biological process	regulation of protein phosphorylation ; negative regulation of cell adhesion ; regulation of GTPase activity ; positive regulation of axonogenesis ; multicellular organism development ; neural tube closure ; brain development ; regulation of cell shape ; neuroblast proliferation ; regulation of neuron migration ; semaphorin-plexin signaling pathway ; signal transduction ; positive regulation of neuron projection development ; homophilic cell adhesion via plasma membrane adhesion molecules ; regulation of cell migration ; semaphorin-plexin signaling pathway involved in axon guidance ; excitatory synapse assembly ;
	Sources:Amigo / QuickGO
Orthologs
	23654
	140570
	ENSG00000196576
	ENSMUSG00000036606
	O15031
	B2RXS4
	NM_012401
	NM_001159521 ; NM_001284506 ; NM_138749
NP_036533 ; NP_001363793 ; NP_001363794 ; NP_001363795 ; NP_001363796 ;
	NP_001363797 ; NP_001363798 ; NP_001363799 ; NP_001363800 ; NP_001363801 ; NP_001363802 ; NP_001363803 ; NP_001363804 ; NP_001363805 ; NP_001363806 ; NP_001363807 ; NP_001363808 ; NP_001363809 ; NP_001363810 ; NP_001363811 ; NP_001363812 ; NP_001363813 ; NP_001363814 ; NP_001363815 Contents Function ; Interactions ; References ; Further reading ;
	NP_001152993 ; NP_001271435 ; NP_620088
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.^[5]^[6]^[7]

Function

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM]^[7]

Interactions

PLXNB2 has been shown to interact with ARHGEF11.^[6]^[8]

Related Research Articles

Erbb2 interacting protein (ERBB2IP), also known as erbin, is a protein which in humans is encoded by the ERBB2IP gene. Discovered in 1997, erbin is a 200kDa protein containing a PDZ domain.

<span class="mw-page-title-main">Plexin</span> Protein

A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classically known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin. Plexin also has implications in development of other body systems by activating GTPase enzymes to induce a number of intracellular biochemical changes leading to a variety of downstream effects.

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene. DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins.

GIPC PDZ domain containing family, member 1 (GIPC1) is a protein that in humans is encoded by the GIPC1 gene. GIPC was originally identified as it binds specifically to the C terminus of RGS-GAIP, a protein involved in the regulation of G protein signaling. GIPC is an acronym for "GAIP Interacting Protein C-terminus". RGS proteins are "Regulators of G protein Signaling" and RGS-GAIP is a "GTPase Activator protein for Gαi/Gαq", which are two major subtypes of Gα proteins. The human GIPC1 molecule is 333 amino acids or about 36 kDa in molecular size and consists of a central PDZ domain, a compact protein module which mediates specific protein-protein interactions. The RGS-GAIP protein interacts with this domain and many other proteins interact here or at other parts of the GIPC1 molecule. As a result, GIPC1 was independently discovered by several other groups and has a variety of alternate names, including synectin, C19orf3, RGS19IP1 and others. The GIPC1 gene family in mammals consisting of three members, so the first discovered, originally named GIPC, is now generally called GIPC1, with the other two being named GIPC2 and GIPC3. The three human proteins are about 60% identical in protein sequence. GIPC1 has been shown to interact with a variety of other receptor and cytoskeletal proteins including the GLUT1 receptor, ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4, SEMA4C/semaphorin-4 and HTLV-I Tax. The general function of GIPC family proteins therefore appears to be mediating specific interactions between proteins involved in G protein signaling and membrane translocation.

Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.

Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. This protein is also called RhoGEF11 or PDZ-RhoGEF.

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. This protein is also called RhoGEF12 or Leukemia-associated Rho guanine nucleotide exchange factor (LARG).

Rnd1 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND1.

Plexin-A1 is a protein that in humans is encoded by the PLXNA1 gene.

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.

Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene.

Plexin-D1 is a protein that in humans is encoded by the PLXND1 gene.

Plexin-A3 is a protein that in humans is encoded by the PLXNA3 gene.

Plexin-A4 is a protein that in humans is encoded by the PLXNA4 gene.

Semaphorin 3E is a protein that in humans is encoded by the SEMA3E gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196576 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036606 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi: 10.1016/S0092-8674(00)80063-X . PMID 10520995.
1 2 Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J Biol Chem. 277 (45): 43115–20. doi: 10.1074/jbc.M206005200 . PMID 12183458.
1 2 "Entrez Gene: PLXNB2 plexin B2".
↑ Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi: 10.1016/S0896-6273(02)00750-X . PMID 12123608.

Shinoura N, Shamraj OI, Hugenholz H, Zhu JG, McBlack P, Warnick R, Tew JJ, Wani MA, Menon AG (1995). "Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors". Cancer Lett. 89 (2): 215–21. doi:10.1016/0304-3835(95)03690-X. PMID 7889532.
Trofatter JA, Long KR, Murrell JR, Stotler CJ, Gusella JF, Buckler AJ (1996). "An expression-independent catalog of genes from human chromosome 22". Genome Res. 5 (3): 214–24. doi: 10.1101/gr.5.3.214 . PMID 8593609.
Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID 9205841.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Artigiani S, Barberis D, Fazzari P, Longati P, Angelini P, van de Loo JW, Comoglio PM, Tamagnone L (2003). "Functional regulation of semaphorin receptors by proprotein convertases". J. Biol. Chem. 278 (12): 10094–101. doi: 10.1074/jbc.M210156200 . PMID 12533544.
Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi: 10.1074/jbc.M303047200 . PMID 12730235.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene. 23 (30): 5131–7. doi: 10.1038/sj.onc.1207650 . PMID 15184888.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196576 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036606 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10520995-5] Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi: 10.1016/S0092-8674(00)80063-X . PMID 10520995.

[pmid12183458-6] 1 2 Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J Biol Chem. 277 (45): 43115–20. doi: 10.1074/jbc.M206005200 . PMID 12183458.

[entrez-7] 1 2 "Entrez Gene: PLXNB2 plexin B2".

[pmid12123608-8] Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi: 10.1016/S0896-6273(02)00750-X . PMID 12123608.

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PLXNB2

Contents

Function

Interactions

Related Research Articles

References

Further reading