PLXNB3

PLXNB3
Identifiers
Aliases	PLXNB3 , PLEXB3, PLEXR, PLXN6, plexin B3
External IDs	OMIM: 300214 MGI: 2154240 HomoloGene: 68468 GeneCards: PLXNB3
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 153,764,196 bp [1] End 153,779,346 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A7.3 Start 73,757,090 bp [2] End 73,772,514 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve hippocampus proper substantia nigra putamen temporal lobe amygdala caudate nucleus sural nerve corpus callosum nucleus accumbens Top expressed in pontine nuclei superior colliculus substantia nigra lateral geniculate nucleus globus pallidus ventral tegmental area sciatic nerve external carotid artery dorsal tegmental nucleus medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function semaphorin receptor activity Rho GDP-dissociation inhibitor binding protein domain specific binding protein binding cell-cell adhesion mediator activity Cellular component integral component of membrane membrane plasma membrane cell surface semaphorin receptor complex integral component of plasma membrane Biological process negative regulation of cell adhesion positive regulation of endothelial cell proliferation positive regulation of axonogenesis nervous system development negative regulation of cell migration negative regulation of GTPase activity regulation of cell shape cell chemotaxis positive chemotaxis semaphorin-plexin signaling pathway signal transduction negative regulation of lamellipodium assembly positive regulation of neuron projection development homophilic cell adhesion via plasma membrane adhesion molecules axon extension regulation of cell migration regulation of GTPase activity semaphorin-plexin signaling pathway involved in axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5365 140571 Ensembl ENSG00000198753 ENSMUSG00000031385 UniProt Q9ULL4 Q9QY40 RefSeq (mRNA) NM_005393 NM_001163257 NM_019587 RefSeq (protein) NP_001156729 NP_005384 NP_062533 Location (UCSC) Chr X: 153.76 – 153.78 Mb Chr X: 73.76 – 73.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene. ^{[5] [6]}

Interactions

PLXNB3 has been shown to interact with ARHGEF11. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000198753 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031385 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi: 10.1016/S0092-8674(00)80063-X . PMID   10520995.
6. "Entrez Gene: PLXNB3 plexin B3".
7. Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry. 277 (45): 43115–20. doi: 10.1074/jbc.M206005200 . PMID   12183458.
8. Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi: 10.1016/S0896-6273(02)00750-X . PMID   12123608.

Further reading

• Sandoval N, Bauer D, Brenner V, Coy JF, Drescher B, Kioschis P, Korn B, Nyakatura G, Poustka A, Reichwald K, Rosenthal A, Platzer M (Jul 1996). "The genomic organization of a human creatine transporter (CRTR) gene located in Xq28". Genomics. 35 (2): 383–5. doi:10.1006/geno.1996.0373. PMID   8661155.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (Aug 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID   9286695.
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Oct 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
• Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry. 277 (45): 43115–20. doi: 10.1074/jbc.M206005200 . PMID   12183458.
• Conrotto P, Corso S, Gamberini S, Comoglio PM, Giordano S (Jul 2004). "Interplay between scatter factor receptors and B plexins controls invasive growth". Oncogene. 23 (30): 5131–7. doi:10.1038/sj.onc.1207650. PMID   15184888. S2CID   24596233.
• Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM, Tamagnone L (Jul 2004). "Plexin-B3 is a functional receptor for semaphorin 5A". EMBO Reports. 5 (7): 710–4. doi:10.1038/sj.embor.7400189. PMC   1299100 . PMID   15218527.
• Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID   15790807. S2CID   13047538.
• Hartwig C, Veske A, Krejcova S, Rosenberger G, Finckh U (2006). "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin". BMC Neuroscience. 6: 53. doi: 10.1186/1471-2202-6-53 . PMC   1215486 . PMID   16122393.
• Rujescu D, Meisenzahl EM, Krejcova S, Giegling I, Zetzsche T, Reiser M, Born CM, Möller HJ, Veske A, Gal A, Finckh U (Feb 2007). "Plexin B3 is genetically associated with verbal performance and white matter volume in human brain". Molecular Psychiatry. 12 (2): 190–4, 115. doi:10.1038/sj.mp.4001903. PMID   17033634. S2CID   2406935.