PNMA2

PNMA2
Identifiers
Aliases	PNMA2 , MA2, MM2, RGAG2, paraneoplastic Ma antigen 2, PNMA family member 2
External IDs	OMIM: 603970 MGI: 2444129 HomoloGene: 5249 GeneCards: PNMA2
Gene location (Human)
Chr.	Chromosome 8 (human)
End	26,514,092 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	67,158,472 bp
RNA expression pattern
	Top expressed in
	orbitofrontal cortex; ; middle temporal gyrus; ; postcentral gyrus; ; superior frontal gyrus; ; Brodmann area 46; ; Brodmann area 23; ; superior vestibular nucleus; ; pons; ; endothelial cell; ; Region I of hippocampus proper;
	Top expressed in
	ventromedial nucleus; ; temporal lobe; ; amygdala; ; lateral hypothalamus; ; facial motor nucleus; ; hippocampus proper; ; substantia nigra; ; paraventricular nucleus of hypothalamus; ; supraoptic nucleus; ; nucleus accumbens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	nucleus ; nucleolus ;
Biological process	positive regulation of apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	10687
	239157
	ENSG00000240694
	ENSMUSG00000046204
	Q9UL42
	Q8BHK0
	NM_007257
	NM_175498
	NP_009188
	NP_780707
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 08, 2023

Paraneoplastic antigen Ma2 is a protein that in humans is encoded by the PNMA2 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000240694 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046204 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Voltz R, Gultekin SH, Rosenfeld MR, Gerstner E, Eichen J, Posner JB, Dalmau J (Jun 1999). "A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer". N Engl J Med. 340 (23): 1788–95. doi: 10.1056/NEJM199906103402303 . PMID 10362822.
↑ "Entrez Gene: PNMA2 paraneoplastic antigen MA2".

Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID 8889549.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.
Dalmau J, Gultekin SH, Voltz R, et al. (1999). "Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders". Brain. 122 (1): 27–39. doi: 10.1093/brain/122.1.27 . PMID 10050892.
Rosenfeld MR, Eichen JG, Wade DF, et al. (2001). "Molecular and clinical diversity in paraneoplastic immunity to Ma proteins". Ann. Neurol. 50 (3): 339–48. doi:10.1002/ana.1288. PMID 11558790. S2CID 24518861.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000240694 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046204 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10362822-5] Voltz R, Gultekin SH, Rosenfeld MR, Gerstner E, Eichen J, Posner JB, Dalmau J (Jun 1999). "A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer". N Engl J Med. 340 (23): 1788–95. doi: 10.1056/NEJM199906103402303 . PMID 10362822.

[entrez-6] "Entrez Gene: PNMA2 paraneoplastic antigen MA2".

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PNMA2

Related Research Articles

References

Further reading