PNMA2

PNMA2
Identifiers
Aliases	PNMA2 , MA2, MM2, RGAG2, paraneoplastic Ma antigen 2, PNMA family member 2
External IDs	OMIM: 603970; MGI: 2444129; HomoloGene: 5249; GeneCards: PNMA2; OMA:PNMA2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.2 Start 26,504,701 bp [1] End 26,514,092 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D1 Start 67,148,619 bp [2] End 67,158,472 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in orbitofrontal cortex middle temporal gyrus postcentral gyrus superior frontal gyrus Brodmann area 46 Brodmann area 23 superior vestibular nucleus lateral nuclear group of thalamus pons endothelial cell Top expressed in ventromedial nucleus lumbar spinal ganglion temporal lobe amygdala lateral septal nucleus anterior amygdaloid area lateral hypothalamus facial motor nucleus hippocampus proper substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleus nucleolus Biological process positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10687 239157 Ensembl ENSG00000240694 ENSMUSG00000046204 UniProt Q9UL42 Q8BHK0 RefSeq (mRNA) NM_007257 NM_175498 RefSeq (protein) NP_009188 NP_780707 Location (UCSC) Chr 8: 26.5 – 26.51 Mb Chr 14: 67.15 – 67.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Paraneoplastic antigen Ma2 is a protein that in humans is encoded by the PNMA2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000240694 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046204 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Voltz R, Gultekin SH, Rosenfeld MR, Gerstner E, Eichen J, Posner JB, Dalmau J (Jun 1999). "A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer". N Engl J Med. 340 (23): 1788–95. doi: 10.1056/NEJM199906103402303 . PMID   10362822.
6. "Entrez Gene: PNMA2 paraneoplastic antigen MA2".

Further reading

• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
• Dalmau J, Gultekin SH, Voltz R, et al. (1999). "Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders". Brain. 122 (1): 27–39. doi: 10.1093/brain/122.1.27 . PMID   10050892.
• Rosenfeld MR, Eichen JG, Wade DF, et al. (2001). "Molecular and clinical diversity in paraneoplastic immunity to Ma proteins". Ann. Neurol. 50 (3): 339–48. doi:10.1002/ana.1288. PMID   11558790. S2CID   24518861.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.