PNPLA8

PNPLA8
Identifiers
Aliases	PNPLA8 , IPLA2(GAMMA), IPLA2-2, IPLA2G, iPLA2gamma, MMLA, PNPLA-gamma, patatin like phospholipase domain containing 8
External IDs	OMIM: 612123; MGI: 1914702; HomoloGene: 12136; GeneCards: PNPLA8; OMA:PNPLA8 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q31.1 Start 108,470,417 bp [1] End 108,569,666 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 B2 Start 44,268,153 bp [2] End 44,369,315 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pancreatic epithelial cell tibialis anterior muscle deltoid muscle entorhinal cortex myocardium of left ventricle pars compacta right ventricle pars reticulata corpus callosum Top expressed in muscle of thigh brown adipose tissue intercostal muscle vastus lateralis muscle temporal muscle myocardium of ventricle sternocleidomastoid muscle triceps brachii muscle mammary gland soleus muscle More reference expression data BioGPS n/a
Gene ontology Molecular function lysophospholipase activity calcium-independent phospholipase A2 activity hydrolase activity ATP binding phospholipase A2 activity Cellular component cytoplasm integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane peroxisomal membrane peroxisome intracellular anatomical structure endoplasmic reticulum perinuclear region of cytoplasm Biological process linoleic acid metabolic process phosphatidylethanolamine acyl-chain remodeling phosphatidylcholine catabolic process lipid metabolism cell death fatty acid metabolic process lipid catabolic process phosphatidylethanolamine catabolic process prostaglandin biosynthetic process metabolism arachidonic acid metabolic process phosphatidylcholine acyl-chain remodeling arachidonic acid secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50640 67452 Ensembl ENSG00000135241 ENSMUSG00000036257 UniProt Q9NP80 Q8K1N1 RefSeq (mRNA) NM_001256007 NM_001256008 NM_001256009 NM_001256010 NM_001256011 NM_015723 NM_026164 RefSeq (protein) NP_001242936 NP_001242937 NP_001242938 NP_001242939 NP_001242940 NP_056538 NP_080440 Location (UCSC) Chr 7: 108.47 – 108.57 Mb Chr 12: 44.27 – 44.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calcium-independent phospholipase A2-gamma is an enzyme that in humans is encoded by the PNPLA8 gene. ^{[5] [6] [7] [8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000135241 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036257 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mancuso DJ, Jenkins CM, Gross RW (May 2000). "The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2)". J Biol Chem. 275 (14): 9937–45. doi: 10.1074/jbc.275.14.9937 . PMID   10744668.
6. Tanaka H, Takeya R, Sumimoto H (Jul 2000). "A novel intracellular membrane-bound calcium-independent phospholipase A(2)". Biochem Biophys Res Commun. 272 (2): 320–6. doi:10.1006/bbrc.2000.2776. PMID   10833412.
7. Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family". J Lipid Res. 47 (9): 1940–9. doi: 10.1194/jlr.M600185-JLR200 . PMID   16799181.
8. Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions". J Lipid Res. 50 Suppl (Supplement): S63–8. doi: 10.1194/jlr.R800082-JLR200 . PMC   2674697 . PMID   19029121.
9. "Entrez Gene: PNPLA8 patatin-like phospholipase domain containing 8".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Wiemann S, Arlt D, Huber W (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Murakami M, Masuda S, Ueda-Semmyo K (2005). "Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2". J. Biol. Chem. 280 (14): 14028–41. doi: 10.1074/jbc.M413766200 . PMID   15695510.
• Mehrle A, Rosenfelder H, Schupp I (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.