POLR1D

POLR1D
Identifiers
Aliases	POLR1D , AC19, POLR1C, RPA16, RPA9, RPAC2, RPC16, RPO1-3, TCS2, polymerase (RNA) I subunit D, RNA polymerase I subunit D, RNA polymerase I and III subunit D
External IDs	OMIM: 613715 MGI: 108403 HomoloGene: 22239 GeneCards: POLR1D
Gene location (Human)
Chr.	Chromosome 13 (human)
End	27,744,237 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	147,111,597 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; secondary oocyte; ; skin of abdomen; ; body of stomach; ; cerebellar hemisphere; ; right uterine tube; ; parotid gland; ; minor salivary gland; ; gastric mucosa; ; monocyte;
	Top expressed in
	facial motor nucleus; ; temporal muscle; ; sternocleidomastoid muscle; ; yolk sac; ; triceps brachii muscle; ; digastric muscle; ; salivary gland; ; submandibular gland; ; lacrimal gland; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; protein dimerization activity ; RNA polymerase III activity ; DNA-directed 5'-3' RNA polymerase activity ; protein binding ; RNA polymerase I activity ;
Cellular component	cytosol ; nucleoplasm ; RNA polymerase I complex ; RNA polymerase III complex ; nucleus ;
Biological process	termination of RNA polymerase I transcription ; epigenetic maintenance of chromatin in transcription-competent conformation ; transcription initiation from RNA polymerase I promoter ; transcription, DNA-templated ; transcription elongation from RNA polymerase I promoter ; positive regulation of type I interferon production ; transcription by RNA polymerase III ;
	Sources:Amigo / QuickGO
Orthologs
	51082
	20018
	ENSG00000186184
	ENSMUSG00000029642
	P0DPB5
	P97304
	NM_001206559 ; NM_015972 ; NM_152705 ; NM_001374407
	NM_009087 ; NM_181730
	NP_001193488 ; NP_057056 ; NP_689918 ; NP_001361336
	NP_033113 ; NP_859419
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 05, 2022

DNA-directed RNA polymerases I and III subunit RPAC2 is a protein that in humans is encoded by the POLR1D gene.^[5]^[6]^[7]

Interactions

POLR1D has been shown to interact with POLR1C.^[8]^[9]

Related Research Articles

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that in humans is encoded by the POLR2A gene.

DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.

DNA-directed RNA polymerase II subunit RPB2 is an enzyme that in humans is encoded by the POLR2B gene.

Elongin A is a protein that in humans is encoded by the ELOA gene.

General transcription factor 3C polypeptide 2 is a protein that in humans is encoded by the GTF3C2 gene.

DNA-directed RNA polymerases I and III subunit RPAC1 is a protein that in humans is encoded by the POLR1C gene.

DNA-directed RNA polymerase I subunit RPA49 is an enzyme that in humans is encoded by the POLR1E gene.

Transcription elongation factor A protein 2 is a protein that in humans is encoded by the TCEA2 gene.

Eukaryotic translation initiation factor 3 subunit G (eIF3g) is a protein that in humans is encoded by the EIF3G gene.

Ribonuclease P protein subunit p38 is an enzyme that in humans is encoded by the RPP38 gene.

Eukaryotic translation initiation factor 3 subunit L (eIF3l), less commonly known as EIF3EIP, is a protein that in humans is encoded by the EIF3L gene.

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.

Cleavage and polyadenylation specificity factor subunit 4 is a protein that in humans is encoded by the CPSF4 gene.

DNA-directed RNA polymerase I subunit RPA12 is an enzyme that in humans is encoded by the ZNRD1 gene.

DNA-directed RNA polymerase III subunit RPC6 is an enzyme that in humans is encoded by the POLR3F gene.

DNA-directed RNA polymerase I subunit RPA34 is an enzyme that in humans is encoded by the CD3EAP gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 is a protein that in humans is encoded by the GNG7 gene.

Cytochrome c oxidase subunit 7A-related protein, mitochondrial is an enzyme that in humans is encoded by the COX7A2L gene.

DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186184 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029642 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.
↑ Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Nov 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740 . PMID 12391170.
↑ "Entrez Gene: POLR1D polymerase (RNA) I polypeptide D, 16kDa".
↑ Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M (Dec 1996). "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III". The Journal of Biological Chemistry. 271 (51): 32881–5. doi: 10.1074/jbc.271.51.32881 . PMID 8955128.
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M (Dec 1996). "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III". The Journal of Biological Chemistry. 271 (51): 32881–5. doi: 10.1074/jbc.271.51.32881 . PMID 8955128.
Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T (Nov 2002). "A kinetic framework for a mammalian RNA polymerase in vivo". Science. 298 (5598): 1623–6. Bibcode:2002Sci...298.1623D. doi:10.1126/science.1076164. PMID 12446911. S2CID 36392120.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jul 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Molecular and Cellular Biology. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256 . PMID 15226435.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186184 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029642 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11042152-5] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.

[pmid12391170-6] Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Nov 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740 . PMID 12391170.

[entrez-7] "Entrez Gene: POLR1D polymerase (RNA) I polypeptide D, 16kDa".

[pmid8955128-8] Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M (Dec 1996). "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III". The Journal of Biological Chemistry. 271 (51): 32881–5. doi: 10.1074/jbc.271.51.32881 . PMID 8955128.

[pmid16189514-9] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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POLR1D

Contents

Interactions

Related Research Articles

References

Further reading