POLR2F

Last updated

POLR2F
Protein POLR2F PDB 1qkl.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLR2F , HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15, polymerase (RNA) II subunit F, RNA polymerase II subunit F, RNA polymerase II, I and III subunit F
External IDs OMIM: 604414; MGI: 1349393; HomoloGene: 7178; GeneCards: POLR2F; OMA:POLR2F - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301129
NM_001301130
NM_001301131
NM_021974
NM_001363825

NM_027231

RefSeq (protein)

NP_001288058
NP_001288059
NP_001288060
NP_068809
NP_001350754

NP_081507

Location (UCSC) Chr 22: 37.95 – 38.04 Mb Chr 15: 79.03 – 79.04 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene. [5]

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. [6]

Interactions

POLR2F has been shown to interact with POLR2C. [7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100142 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033020 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pusch C, Wang Z, Roe B, et al. (September 1996). "Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity". Genomics. 34 (3): 440–2. doi:10.1006/geno.1996.0312. PMID   8786150.
  6. "Entrez Gene: POLR2F polymerase (RNA) II (DNA directed) polypeptide F".
  7. Acker J, de Graaff M, Cheynel I, et al. (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27). UNITED STATES: 16815–21. doi: 10.1074/jbc.272.27.16815 . ISSN   0021-9258. PMID   9201987.

Further reading