POLR2K

POLR2K
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	POLR2K , ABC10-alpha, RPABC4, RPB10alpha, RPB12, RPB7.0, hRPB7.0, hsRPB10a, polymerase (RNA) II subunit K, RNA polymerase II subunit K, RNA polymerase II, I and III subunit K
External IDs	OMIM: 606033 MGI: 102725 HomoloGene: 86049 GeneCards: POLR2K
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q22.2 Start 100,150,623 bp [1] End 100,154,003 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 B3.1 Start 36,174,156 bp [2] End 36,177,156 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans Achilles tendon Brodmann area 9 left adrenal gland right adrenal gland rectum ganglionic eminence left coronary artery thoracic aorta amygdala Top expressed in quadriceps femoris muscle morula neural tube yolk sac ganglionic eminence proximal tubule lens blastocyst stomach muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding zinc ion binding RNA polymerase II activity metal ion binding RNA polymerase III activity DNA-directed 5'-3' RNA polymerase activity RNA polymerase I activity Cellular component cytosol nucleoplasm RNA polymerase I complex RNA polymerase III complex RNA polymerase II, core complex nucleus Biological process termination of RNA polymerase I transcription mRNA splicing, via spliceosome epigenetic maintenance of chromatin in transcription-competent conformation regulation of transcription by RNA polymerase I transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter transcription by RNA polymerase III snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5440 17749 Ensembl ENSG00000147669 ENSMUSG00000045996 UniProt P53803 Q63871 RefSeq (mRNA) NM_005034 NM_001039368 NM_023127 RefSeq (protein) NP_005025 NP_001034457 NP_075616 Location (UCSC) Chr 8: 100.15 – 100.15 Mb Chr 15: 36.17 – 36.18 Mb PubMed search [3] [4]
Wikidata
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DNA-directed RNA polymerases I, II, and III subunit RPABC4 is a protein that in humans is encoded by the POLR2K gene.

This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. ^[5]

Interactions

POLR2K has been shown to interact with POLR2C. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000147669 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045996 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa".
6. Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". The Journal of Biological Chemistry. 272 (27): 16815–21. doi: 10.1074/jbc.272.27.16815 . PMID   9201987.

Further reading

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". Journal of Biomedical Science. 5 (1): 24–7. doi:10.1007/BF02253352. PMID   9570510.
• Yankulov K, Bentley D (June 1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Current Biology. 8 (13): R447-9. Bibcode:1998CBio....8.R447Y. doi: 10.1016/S0960-9822(98)70289-1 . PMID   9651670. S2CID   15480646.
• Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A (December 1999). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". Journal of Cellular Biochemistry. 75 (3): 357–68. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID   10536359. S2CID   43685090.
• Marcello A, Zoppé M, Giacca M (March 2001). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–81. doi: 10.1080/152165401753544241 . PMID   11547919. S2CID   10931640.
• Howe KJ (September 2002). "RNA polymerase II conducts a symphony of pre-mRNA processing activities". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1577 (2): 308–24. doi:10.1016/s0167-4781(02)00460-8. PMID   12213660.
• Stevens M, De Clercq E, Balzarini J (September 2006). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Medicinal Research Reviews. 26 (5): 595–625. doi:10.1002/med.20081. PMC   7168390 . PMID   16838299.
• Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (December 2006). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID   17168834.
• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–7. PMID   1403646.
• Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (April 1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes & Development. 6 (4): 655–66. doi: 10.1101/gad.6.4.655 . PMID   1559613.
• Southgate C, Zapp ML, Green MR (June 1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". Nature. 345 (6276): 640–2. Bibcode:1990Natur.345..640S. doi:10.1038/345640a0. PMID   2190099. S2CID   4233742.
• Wu-Baer F, Sigman D, Gaynor RB (August 1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. doi: 10.1073/pnas.92.16.7153 . PMC   41297 . PMID   7638159.
• Shpakovski GV, Acker J, Wintzerith M, Lacroix JF, Thuriaux P, Vigneron M (September 1995). "Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae". Molecular and Cellular Biology. 15 (9): 4702–10. doi:10.1128/mcb.15.9.4702. PMC   230713 . PMID   7651387.
• Herrmann CH, Rice AP (March 1995). "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor". Journal of Virology. 69 (3): 1612–20. doi:10.1128/JVI.69.3.1612-1620.1995. PMC   188757 . PMID   7853496.
• Keen NJ, Gait MJ, Karn J (March 1996). "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex". Proceedings of the National Academy of Sciences of the United States of America. 93 (6): 2505–10. Bibcode:1996PNAS...93.2505K. doi: 10.1073/pnas.93.6.2505 . PMC   39827 . PMID   8637904.
• Yang X, Herrmann CH, Rice AP (July 1996). "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function". Journal of Virology. 70 (7): 4576–84. doi:10.1128/JVI.70.7.4576-4584.1996. PMC   190394 . PMID   8676484.
• Agostini I, Navarro JM, Rey F, Bouhamdan M, Spire B, Vigne R, Sire J (September 1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". Journal of Molecular Biology. 261 (5): 599–606. doi:10.1006/jmbi.1996.0485. PMID   8800208.
• Zhou Q, Sharp PA (October 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID   8849451. S2CID   13266489.
• Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (October 1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proceedings of the National Academy of Sciences of the United States of America. 93 (21): 11575–9. Bibcode:1996PNAS...9311575O. doi: 10.1073/pnas.93.21.11575 . PMC   38099 . PMID   8876177.
• Chun RF, Jeang KT (November 1996). "Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1". The Journal of Biological Chemistry. 271 (44): 27888–94. doi: 10.1074/jbc.271.44.27888 . PMID   8910388.
• Parada CA, Roeder RG (November 1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. Bibcode:1996Natur.384..375P. doi:10.1038/384375a0. PMID   8934526. S2CID   4278432.