POLR3C

POLR3C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XUB, 2XV4, 5AFQ
Identifiers
Aliases	POLR3C , RPC3, RPC62, polymerase (RNA) III subunit C, RNA polymerase III subunit C, C82
External IDs	OMIM: 617454 MGI: 1921664 HomoloGene: 38185 GeneCards: POLR3C
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.1 Start 145,824,088 bp [1] End 145,844,402 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.1 Start 96,618,806 bp [2] End 96,634,944 bp [2]
RNA expression pattern Bgee Top expressed in testicle corpus callosum Achilles tendon thymus ovary kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity DNA binding GO:0001948 protein binding RNA polymerase III activity single-stranded DNA binding Cellular component RNA polymerase III complex cytosol nucleoplasm nucleus Biological process positive regulation of interferon-beta production regulation of transcription by RNA polymerase III defense response to virus transcription, DNA-templated positive regulation of innate immune response immune system process innate immune response transcription by RNA polymerase III positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10623	74414
Ensembl	ENSG00000186141	ENSMUSG00000028099
UniProt	Q9BUI4	Q9D483
RefSeq (mRNA)	NM_001303456 NM_006468	NM_028925
RefSeq (protein)	NP_001290385 NP_006459	NP_083201
Location (UCSC)	Chr 1: 145.82 – 145.84 Mb	Chr 3: 96.62 – 96.63 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene. ^{[5] [6] [7]}

Interactions

POLR3C has been shown to interact with GTF3C4. ^{[8] [9]}

Related gene problems

• TAR syndrome ^[10]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

References

1. GRCh38: Ensembl release 89: ENSG00000186141 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028099 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang Z, Roeder RG (May 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes & Development. 11 (10): 1315–26. doi: 10.1101/gad.11.10.1315 . PMID   9171375.
6. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (November 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC   134740 . PMID   12391170.
7. "Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)".
8. Hsieh YJ, Wang Z, Kovelman R, Roeder RG (July 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Molecular and Cellular Biology. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC   84305 . PMID   10373544.
9. Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC   84812 . PMID   10523658.
10. Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". American Journal of Human Genetics. 80 (2): 232–40. doi:10.1086/510919. PMC   1785342 . PMID   17236129.

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–7. PMID   1403646.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hsieh YJ, Wang Z, Kovelman R, Roeder RG (July 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Molecular and Cellular Biology. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC   84305 . PMID   10373544.
• Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC   84812 . PMID   10523658.
• Kuwana M, Kimura K, Kawakami Y (October 2002). "Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay". Arthritis and Rheumatism. 46 (10): 2742–7. doi: 10.1002/art.10521 . PMID   12384934.