POLR3D

POLR3D
Identifiers
Aliases	POLR3D , BN51T, RPC4, RPC53, TSBN51, polymerase (RNA) III subunit D, RNA polymerase III subunit D, C53
External IDs	OMIM: 187280; MGI: 1914315; HomoloGene: 1303; GeneCards: POLR3D; OMA:POLR3D - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.3 Start 22,245,133 bp [1] End 22,254,601 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 D2 Start 70,676,197 bp [2] End 70,680,887 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium Achilles tendon gastrocnemius muscle muscle of thigh islet of Langerhans ventricular zone ganglionic eminence left testis right testis Top expressed in otic placode saccule otic vesicle yolk sac tail of embryo ventricular zone muscle of thigh epiblast embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity DNA binding chromatin binding RNA polymerase III activity Cellular component RNA polymerase III complex nucleus nucleoplasm cytosol nuclear speck Biological process positive regulation of interferon-beta production immune system process defense response to virus positive regulation of innate immune response transcription by RNA polymerase III innate immune response positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 661 67065 Ensembl ENSG00000168495 ENSMUSG00000000776 UniProt P05423 Q91WD1 RefSeq (mRNA) NM_001722 NM_001164082 NM_025945 RefSeq (protein) NP_001713 NP_001157554 NP_080221 Location (UCSC) Chr 8: 22.25 – 22.25 Mb Chr 14: 70.68 – 70.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene. ^{[5] [6] [7]}

This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. ^[7]

Interactions

POLR3D has been shown to interact with POLR3E. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000168495 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000776 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Mol Cell Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC   134740 . PMID   12391170.
6. Chong SS, Hu P, Hernandez N (Jun 2001). "Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex". J Biol Chem. 276 (23): 20727–34. doi: 10.1074/jbc.M100088200 . PMID   11279001.
7. "Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa".

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID   1403646.
• Greco A, Ittmann M, Barletta C, et al. (1989). "Chromosomal localization of human genes required for G1 progression in mammalian cells". Genomics. 4 (3): 240–5. doi:10.1016/0888-7543(89)90326-1. PMID   2714790.
• Ittmann M, Greco A, Basilico C (1988). "Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells". Mol. Cell. Biol. 7 (10): 3386–93. doi:10.1128/MCB.7.10.3386. PMC   367988 . PMID   3683386.
• Jackson AJ, Ittmann M, Pugh BF (1995). "The BN51 protein is a polymerase (Pol)-specific subunit of RNA Pol III which reveals a link between Pol III transcription and pre-rRNA processing". Mol. Cell. Biol. 15 (1): 94–101. doi:10.1128/MCB.15.1.94. PMC   231913 . PMID   7799973.
• Ittmann MM (1994). "Cell cycle control of the BN51 cell cycle gene which encodes a subunit of RNA polymerase III". Cell Growth Differ. 5 (7): 783–8. PMID   7947392.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.