POLR3E

POLR3E
Identifiers
Aliases	POLR3E , RPC5, SIN, polymerase (RNA) III subunit E, RNA polymerase III subunit E, C37
External IDs	OMIM: 617815; MGI: 1349452; HomoloGene: 14052; GeneCards: POLR3E; OMA:POLR3E - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p12.2 Start 22,297,375 bp [1] End 22,335,101 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F2 Start 120,516,967 bp [2] End 120,546,655 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh body of pancreas left lobe of thyroid gland anterior pituitary right lobe of thyroid gland skin of leg skin of abdomen right uterine tube left ovary Top expressed in right kidney proximal tubule human kidney epiblast hair follicle seminiferous tubule endothelial cell of lymphatic vessel condyle yolk sac Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity RNA polymerase III activity Cellular component RNA polymerase III complex cytosol nucleus nucleoplasm Biological process immune system process defense response to virus transcription, DNA-templated transcription by RNA polymerase III innate immune response positive regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55718 26939 Ensembl ENSG00000284282 ENSG00000058600 ENSMUSG00000030880 UniProt Q9NVU0 Q9CZT4 RefSeq (mRNA) NM_001258033 NM_001258034 NM_001258035 NM_001258036 NM_018119 NM_001164096 NM_025298 NM_001379288 RefSeq (protein) NP_001244962 NP_001244963 NP_001244964 NP_001244965 NP_060589 NP_001157568 NP_079574 NP_001366217 Location (UCSC) Chr 16: 22.3 – 22.34 Mb Chr 7: 120.52 – 120.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC5 is an enzyme that in humans is encoded by the POLR3E gene. ^{[5] [6] [7]}

Interactions

POLR3E has been shown to interact with POLR3D. ^[8]

Notes and references

1. ENSG00000058600 GRCh38: Ensembl release 89: ENSG00000284282, ENSG00000058600 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030880 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–150. doi: 10.1093/dnares/7.2.143 . PMID   10819331.
6. Dong Z, Bell LR (Nov 1999). "SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal". Gene. 237 (2): 421–428. doi:10.1016/S0378-1119(99)00303-0. PMID   10521666.
7. "Entrez Gene: POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)".
8. Hu, Ping; Wu Si; Sun Yuling; Yuan Chih-Chi; Kobayashi Ryuji; Myers Michael P; Nouria Hernandez (Nov 2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits" (PDF). Mol. Cell. Biol. 22 (22). United States: 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. ISSN   0270-7306. PMC   134740 . PMID   12391170.

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–1147. PMID   1403646.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hu P, Wu S, Sun Y, et al. (2002). "Characterization of Human RNA Polymerase III Identifies Orthologues for Saccharomyces cerevisiae RNA Polymerase III Subunits". Mol. Cell. Biol. 22 (22): 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. PMC   134740 . PMID   12391170.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.