POMP

Last updated
POMP
Identifiers
Aliases POMP , C13orf12, PNAS-110, UMP1, HSPC014, proteasome maturation protein, PRAAS2
External IDs OMIM: 613386 MGI: 1913787 HomoloGene: 41077 GeneCards: POMP
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015932

NM_025624

RefSeq (protein)

NP_057016

NP_079900

Location (UCSC) Chr 13: 28.66 – 28.68 Mb Chr 5: 147.8 – 147.81 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proteasome maturation protein is a protein that in humans is encoded by the POMP gene. [5] [6] It is a short-lived maturation factor required for 20S proteasome subunit biogenesis.

A single nucleotide deletion in this gene causes an autosomal recessive skin disorder, keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK) syndrome. [7]

Related Research Articles

<span class="mw-page-title-main">PSMC3</span> Enzyme found in humans

26S protease regulatory subunit 6A, also known as 26S proteasome AAA-ATPase subunit Rpt5, is an enzyme that in humans is encoded by the PSMC3 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits together with four non-ATPase subunits form the base sub complex of 19S regulatory particle for proteasome complex.

<span class="mw-page-title-main">PSMB1</span> Protein found in humans

Proteasome subunit beta type-1 also known as 20S proteasome subunit beta-6 is a protein that in humans is encoded by the PSMB1 gene. This protein is one of the 17 essential subunits that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-1, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

<span class="mw-page-title-main">EIF3S6</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit E (eIF3e) is a protein that in humans is encoded by the EIF3E gene.

<span class="mw-page-title-main">PSMB9</span> Protein found in humans

Proteasome subunit beta type-9 as known as 20S proteasome subunit beta-1i is a protein that in humans is encoded by the PSMB9 gene.

<span class="mw-page-title-main">PSMC4</span> Enzyme found in humans

26S protease regulatory subunit 6B, also known as 26S proteasome AAA-ATPase subunit Rpt3, is an enzyme that in humans is encoded by the PSMC4 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits together with four non-ATPase subunits form the base sub complex of 19S regulatory particle for proteasome complex.

<span class="mw-page-title-main">PSMD7</span> Enzyme found in humans

26S proteasome non-ATPase regulatory subunit 7, also known as 26S proteasome non-ATPase subunit Rpn8, is an enzyme that in humans is encoded by the PSMD7 gene.

<span class="mw-page-title-main">PSMF1</span> Protein found in humans

Proteasome inhibitor PI31 subunit is a protein that in humans is encoded by the PSMF1 gene.

<span class="mw-page-title-main">PSMD1</span> Protein found in humans

26S proteasome non-ATPase regulatory subunit 1, also as known as 26S Proteasome Regulatory Subunit Rpn2, is a protein that in humans is encoded by the PSMD1 gene. This protein is one of the 19 essential subunits that contributes to the complete assembly of 19S proteasome complex.

<span class="mw-page-title-main">SIAH2</span>

E3 ubiquitin-protein ligase SIAH2 is an enzyme that in humans is encoded by the SIAH2 gene.

<span class="mw-page-title-main">ANAPC1</span> Protein-coding gene in the species Homo sapiens

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.

<span class="mw-page-title-main">RPN1</span>

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 1 is an enzyme that in humans is encoded by the RPN1 gene.

<span class="mw-page-title-main">CSTF3</span> Protein-coding gene in the species Homo sapiens

Cleavage stimulation factor 77 kDa subunit is a protein that in humans is encoded by the CSTF3 gene.

<span class="mw-page-title-main">COPS7A</span>

COP9 signalosome complex subunit 7a is a protein that in humans is encoded by the COPS7A gene.

<span class="mw-page-title-main">Ubiquitin carboxyl-terminal hydrolase L5</span>

Ubiquitin carboxyl-terminal hydrolase isozyme L5 is an enzyme that in humans is encoded by the UCHL5 gene.

<span class="mw-page-title-main">MED31</span>

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene. It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.

<span class="mw-page-title-main">40S ribosomal protein S28</span> Protein-coding gene in the species Homo sapiens

40S ribosomal protein S28 is a protein that in humans is encoded by the RPS28 gene.

<span class="mw-page-title-main">RPS15</span> Protein-coding gene in the species Homo sapiens

40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.

<span class="mw-page-title-main">PSMG1</span> Protein found in humans

Proteasome assembly chaperone 1 is a protein that in humans is encoded by the PSMG1 gene.

<span class="mw-page-title-main">RRP15</span> Protein-coding gene in the species Homo sapiens

RRP15-like protein is a protein that in humans is encoded by the RRP15 gene.

<span class="mw-page-title-main">RNASEH2A</span> Protein-coding gene in the species Homo sapiens

Ribonuclease H2 subunit A, also known as RNase H2 subunit A, is an enzyme that in humans is encoded by the RNASEH2A gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132963 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029649 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
  6. "Entrez Gene: POMP proteasome maturation protein".
  7. Foley CC, Paller AS, Irvine AD (2015). "Chapter 19: Disorders of cornification (icthyosis)". In Eichenfield LF, Frieden IJ (eds.). Neonatal and infant dermatology (3rd ed.). Elsevier Inc. p. 301. ISBN   978-1-4557-2638-7.

Further reading