PON2

PON2
Identifiers
Aliases	PON2 , paraoxonase 2
External IDs	OMIM: 602447 MGI: 106687 HomoloGene: 385 GeneCards: PON2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	95,435,329 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	5,298,455 bp
RNA expression pattern
	Top expressed in
	right lung; ; nucleus accumbens; ; amygdala; ; putamen; ; external globus pallidus; ; jejunal mucosa; ; left adrenal gland; ; caudate nucleus; ; corpus callosum; ; upper lobe of left lung;
	Top expressed in
	epithelium of stomach; ; ciliary body; ; mucous cell of stomach; ; retinal pigment epithelium; ; corneal stroma; ; ileum; ; right lung lobe; ; lacrimal gland; ; salivary gland; ; seminal vesicula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hydrolase activity ; metal ion binding ; identical protein binding ; arylesterase activity ; acyl-L-homoserine-lactone lactonohydrolase activity ;
Cellular component	plasma membrane ; lysosome ; mitochondrion ; nucleus ; membrane ; intracellular membrane-bounded organelle ; extracellular region ;
Biological process	aromatic compound catabolic process ; response to oxidative stress ; response to toxic substance ; lipoxygenase pathway ;
	Sources:Amigo / QuickGO
Orthologs
	5445
	330260
	ENSG00000105854
	ENSMUSG00000032667
	Q15165
	Q62086
	NM_000305 ; NM_001018161
	NM_183308
	NP_000296 ; NP_001018171
	NP_899131
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 30, 2023

Serum paraoxonase/arylesterase 2 is an enzyme that in humans is encoded by the PON2 gene.^[5]^[6]^[7]

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105854 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032667 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (Sep 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID 8661009.
↑ Mochizuki H, Scherer SW, Xi T, Nickle DC, Majer M, Huizenga JJ, Tsui LC, Prochazka M (Aug 1998). "Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence". Gene. 213 (1–2): 149–57. doi:10.1016/S0378-1119(98)00193-0. PMID 9714608.
1 2 "Entrez Gene: PON2 paraoxonase 2".

Mackness B, Durrington PN, Mackness MI (2003). "The paraoxonase gene family and coronary heart disease". Curr. Opin. Lipidol. 13 (4): 357–62. doi:10.1097/00041433-200208000-00002. PMID 12151850. S2CID 22912885.
Getz GS, Reardon CA (2005). "Paraoxonase, a cardioprotective enzyme: continuing issues". Curr. Opin. Lipidol. 15 (3): 261–7. doi:10.1097/00041433-200406000-00005. PMID 15166781. S2CID 23497678.
Ng CJ, Shih DM, Hama SY, et al. (2005). "The paraoxonase gene family and atherosclerosis". Free Radic. Biol. Med. 38 (2): 153–63. doi:10.1016/j.freeradbiomed.2004.09.035. PMID 15607899.
Hegele RA, Connelly PW, Scherer SW, et al. (1997). "Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus". J. Clin. Endocrinol. Metab. 82 (10): 3373–7. CiteSeerX 10.1.1.541.2763 . doi:10.1210/jcem.82.10.4289. PMID 9329371. S2CID 13102917.
Sanghera DK, Aston CE, Saha N, Kamboh MI (1998). "DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease". Am. J. Hum. Genet. 62 (1): 36–44. doi:10.1086/301669. PMC 1376796 . PMID 9443862.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.
Ng CJ, Wadleigh DJ, Gangopadhyay A, et al. (2002). "Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein". J. Biol. Chem. 276 (48): 44444–9. doi: 10.1074/jbc.M105660200 . PMID 11579088.
Hong SH, Song J, Min WK, Kim JQ (2002). "Genetic variations of the paraoxonase gene in patients with coronary artery disease". Clin. Biochem. 34 (6): 475–81. doi:10.1016/S0009-9120(01)00257-0. PMID 11676977.
Obineche EN, Frossard PM, Bokhari AM (2002). "An association study of five genetic loci and left ventricular hypertrophy amongst Gulf Arabs". Hypertens. Res. 24 (6): 635–9. doi: 10.1291/hypres.24.635 . PMID 11768721.
Janka Z, Juhász A, Rimanóczy AA, et al. (2002). "Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias". Mol. Psychiatry. 7 (1): 110–2. doi:10.1038/sj/mp/4000916. PMID 11803456.
Kao Y, Donaghue KC, Chan A, et al. (2002). "Paraoxonase gene cluster is a genetic marker for early microvascular complications in type 1 diabetes". Diabet. Med. 19 (3): 212–5. doi:10.1046/j.1464-5491.2002.00660.x. PMID 11918623. S2CID 11658029.
Chen Q, Reis SE, Kammerer CM, et al. (2003). "Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study". Am. J. Hum. Genet. 72 (1): 13–22. doi:10.1086/345312. PMC 378617 . PMID 12454802.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID 12853948.
Yamada Y, Ando F, Niino N, et al. (2003). "Association of polymorphisms of paraoxonase 1 and 2 genes, alone or in combination, with bone mineral density in community-dwelling Japanese". J. Hum. Genet. 48 (9): 469–75. doi: 10.1007/s10038-003-0063-x . PMID 12955589.
Shi J, Zhang S, Tang M, et al. (2004). "Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese". Brain Res. Mol. Brain Res. 120 (2): 201–4. doi:10.1016/j.molbrainres.2003.10.018. PMID 14741412.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105854 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032667 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8661009-5] Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (Sep 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID 8661009.

[pmid9714608-6] Mochizuki H, Scherer SW, Xi T, Nickle DC, Majer M, Huizenga JJ, Tsui LC, Prochazka M (Aug 1998). "Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence". Gene. 213 (1–2): 149–57. doi:10.1016/S0378-1119(98)00193-0. PMID 9714608.

[entrez-7] 1 2 "Entrez Gene: PON2 paraoxonase 2".

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PON2

Related Research Articles

References

Further reading