PON3

PON3
Identifiers
Aliases	PON3 , paraoxonase 3
External IDs	OMIM: 602720; MGI: 106686; HomoloGene: 37371; GeneCards: PON3; OMA:PON3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q21.3 Start 95,359,872 bp [1] End 95,396,375 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver parotid gland pituitary gland left ovary anterior pituitary testicle gonad palpebral conjunctiva right ovary islet of Langerhans n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function arylesterase activity dihydrocoumarin hydrolase activity 3,4-dihydrocoumarin hydrolase activity aryldialkylphosphatase activity hydrolase activity protein homodimerization activity metal ion binding acyl-L-homoserine-lactone lactonohydrolase activity Cellular component extracellular exosome intracellular membrane-bounded organelle extracellular region extracellular space Biological process carboxylic acid catabolic process negative regulation of superoxide anion generation phenylacetate catabolic process coumarin catabolic process aromatic compound catabolic process response to toxic substance response to external stimulus dephosphorylation lipoxygenase pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5446 269823 Ensembl ENSG00000105852 n/a UniProt Q15166 Q62087 RefSeq (mRNA) NM_000940 NM_173006 NM_001363812 RefSeq (protein) NP_000931 NP_766594 NP_001350741 Location (UCSC) Chr 7: 95.36 – 95.4 Mb n/a PubMed search [2] [3]
Wikidata
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Paraoxonase 3, also known as PON3, is a protein which in humans is encoded by the PON3 gene. ^{[4] [5]}

Function

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000105852 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (May 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID   8661009.
5. "Entrez Gene: PON3 paraoxonase 3".

Further reading

• Mackness B, Durrington PN, Mackness MI (2003). "The paraoxonase gene family and coronary heart disease". Curr. Opin. Lipidol. 13 (4): 357–62. doi:10.1097/00041433-200208000-00002. PMID   12151850. S2CID   22912885.
• Ng CJ, Shih DM, Hama SY, et al. (2005). "The paraoxonase gene family and atherosclerosis". Free Radic. Biol. Med. 38 (2): 153–63. doi:10.1016/j.freeradbiomed.2004.09.035. PMID   15607899.
• Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID   8661009.
• La Du BN (2001). "Is paraoxonase-3 another hdl-associated protein protective against atherosclerosis?". Arterioscler. Thromb. Vasc. Biol. 21 (4): 467–8. doi: 10.1161/01.ATV.21.4.467 . PMID   11304457.
• Reddy ST, Wadleigh DJ, Grijalva V, et al. (2001). "Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids". Arterioscler. Thromb. Vasc. Biol. 21 (4): 542–7. doi: 10.1161/01.ATV.21.4.542 . PMID   11304470.
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. Bibcode:2001PNAS...9815089X. doi: 10.1073/pnas.241522398 . PMC   64988 . PMID   11752456.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Aharoni A, Gaidukov L, Yagur S, et al. (2004). "Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization". Proc. Natl. Acad. Sci. U.S.A. 101 (2): 482–7. Bibcode:2004PNAS..101..482A. doi: 10.1073/pnas.2536901100 . PMC   327173 . PMID   14695884.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Jin P, Fu GK, Wilson AD, et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics. 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID   15028279.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Draganov DI, Teiber JF, Speelman A, et al. (2005). "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities". J. Lipid Res. 46 (6): 1239–47. doi: 10.1194/jlr.M400511-JLR200 . PMID   15772423.
• Shamir R, Hartman C, Karry R, et al. (2005). "Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line: selective secretion of PON1 and PON2". Free Radic. Biol. Med. 39 (3): 336–44. doi:10.1016/j.freeradbiomed.2005.03.016. PMID   15993332.
• Lu H, Zhu J, Zang Y, et al. (2005). "Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product". Biochem. Pharmacol. 70 (7): 1019–25. doi:10.1016/j.bcp.2005.07.004. PMID   16099434.
• Lu H, Zhu J, Zang Y, et al. (2006). "Cloning, purification, and refolding of human paraoxonase-3 expressed in Escherichia coli and its characterization". Protein Expr. Purif. 46 (1): 92–9. doi:10.1016/j.pep.2005.07.021. PMID   16139510.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.