POP4 (gene)

POP4
Identifiers
Aliases	POP4 , RPP29, POP4 homolog, ribonuclease P/MRP subunit
External IDs	OMIM: 606114; MGI: 1913411; HomoloGene: 31392; GeneCards: POP4; OMA:POP4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q12 Start 29,606,283 bp [1] End 29,617,237 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B3 Start 37,961,420 bp [2] End 37,970,847 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland granulocyte right coronary artery left adrenal cortex mucosa of transverse colon buccal mucosa cell left coronary artery olfactory zone of nasal mucosa Top expressed in ganglionic eminence blastocyst ventricular zone maxillary prominence mandibular prominence medial ganglionic eminence morula dermis endothelial cell of lymphatic vessel genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribonuclease activity protein binding ribonuclease P RNA binding ribonuclease MRP activity hydrolase activity RNA binding ribonuclease P activity Cellular component ribonuclease P complex nucleolus nucleus nucleoplasm multimeric ribonuclease P complex ribonuclease MRP complex Biological process tRNA processing RNA phosphodiester bond hydrolysis, endonucleolytic tRNA 5'-leader removal rRNA processing RNA processing RNA phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10775 66161 Ensembl ENSG00000105171 ENSMUSG00000030423 UniProt O95707 Q9CR08 RefSeq (mRNA) NM_006627 NM_025390 RefSeq (protein) NP_006618 NP_079666 Location (UCSC) Chr 19: 29.61 – 29.62 Mb Chr 7: 37.96 – 37.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribonuclease P protein subunit p29 is an enzyme that in humans is encoded by the POP4 gene. ^{[5] [6] [7]}

Interactions

POP4 has been shown to interact with RPP38 ^[8] and POP1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000105171 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030423 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. van Eenennaam H, Pruijn GJ, van Venrooij WJ (Jul 1999). "hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes". Nucleic Acids Res. 27 (12): 2465–72. doi:10.1093/nar/27.12.2465. PMC   148449 . PMID   10352175.
6. Jarrous N, Eder PS, Wesolowski D, Altman S (Mar 1999). "Rpp14 and Rpp29, two protein subunits of human ribonuclease P". RNA. 5 (2) S135583829800185X: 153–7. doi:10.1017/S135583829800185X. PMC   1369747 . PMID   10024167.
7. "Entrez Gene: POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)".
8. Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC   407822 . PMID   15096576.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC   407822 . PMID   15096576.
• Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P". RNA. 7 (7) S1355838201010299: 937–41. doi:10.1017/S1355838201010299. PMC   1370153 . PMID   11455963.