POU2F3

POU2F3
Identifiers
Aliases	POU2F3 , Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a, POU class 2 homeobox 3
External IDs	OMIM: 607394 MGI: 102565 HomoloGene: 7898 GeneCards: POU2F3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	120,319,945 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	43,121,666 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; nipple; ; vulva; ; palpebral conjunctiva; ; human penis; ; pancreatic ductal cell; ; vagina; ; hair follicle; ; minor salivary gland; ; amniotic fluid;
	Top expressed in
	lip; ; urethra; ; male urethra; ; zone of skin; ; skin of back; ; morula; ; secondary oocyte; ; epidermis; ; motor neuron; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding ; DNA-binding transcription factor activity ; sequence-specific DNA binding ; DNA binding ; DNA-binding transcription activator activity, RNA polymerase II-specific ; protein binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; positive regulation of transcription by RNA polymerase II ; transcription by RNA polymerase II ; regulation of transcription by RNA polymerase II ; epidermis development ;
	Sources:Amigo / QuickGO
Orthologs
	25833
	18988
	ENSG00000137709
	ENSMUSG00000032015
	Q9UKI9
	P31362
	NM_001244682 ; NM_014352
	NM_011139
	NP_001231611 ; NP_055167
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 05, 2024

POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.^[5]^[6]

Related Research Articles

NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene.

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

Calcium/calmodulin-dependent protein kinase type 1 is an enzyme that in humans is encoded by the CAMK1 gene.

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.

General transcription factor II-I repeat domain-containing protein 1 is a protein that in humans is encoded by the GTF2IRD1 gene.

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein, is a protein that in humans is encoded by the MST1 gene.

Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.

Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation.

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene.

Vinexin is a protein that in humans is encoded by the SORBS3 gene.

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.

POU domain, class 3, transcription factor 1 is a protein that in humans is encoded by the POU3F1 gene.

Small proline-rich protein 2A is a protein that in humans is encoded by the SPRR2A gene.

Transcription factor RFX4 is a protein that in humans is encoded by the RFX4 gene.

Protein HEXIM2 is a protein that in humans is encoded by the HEXIM2 gene.

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene. ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes and has a role in development.[supplied by OMIM]

E74 like ETS transcription factor 3 is a protein that in humans is encoded by the ELF3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137709 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032015 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hildesheim J, Foster RA, Chamberlin ME, Vogel JC (Oct 1999). "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor". J Biol Chem. 274 (37): 26399–406. doi: 10.1074/jbc.274.37.26399 . PMID 10473598.
↑ "Entrez Gene: POU2F3 POU domain, class 2, transcription factor 3".

Goldsborough A, et al. (1990). "Cloning and sequencing of POU-boxes expressed in mouse testis". Nucleic Acids Res. 18 (6): 1634. doi:10.1093/nar/18.6.1634. PMC 330540 . PMID 1970171.
Goldsborough AS, Healy LE, Copeland NG, et al. (1993). "Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11". Nucleic Acids Res. 21 (1): 127–34. doi:10.1093/nar/21.1.127. PMC 309074 . PMID 8441607.
Sugihara TM, Kudryavtseva EI, Kumar V, et al. (2001). "The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300". J. Biol. Chem. 276 (35): 33036–44. doi: 10.1074/jbc.M103000200 . PMID 11429405.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi: 10.1074/jbc.M300508200 . hdl: 1887/50054 . PMID 12624109.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Enomoto Y, Enomoto K, Kitamura T, Kanda T (2004). "Keratinocyte-specific POU transcription factor hSkn-1a represses the growth of cervical cancer cell lines". Oncogene. 23 (29): 5014–22. doi: 10.1038/sj.onc.1207653 . PMID 15077167.
Jiménez-Mateo O, Rodríguez-Torres A, Avila S, Castrillo JL (2006). "The transcription factor PLA-1/SKN-1A is expressed in human placenta and regulates the placental lactogen-3 gene expression". Placenta. 27 (4–5): 357–66. doi:10.1016/j.placenta.2005.03.011. PMID 16005513.
Zhang Z, Huettner PC, Nguyen L, et al. (2006). "Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer". Oncogene. 25 (39): 5436–45. doi: 10.1038/sj.onc.1209530 . PMID 16607278.
Beck IM, Müller M, Mentlein R, et al. (2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation". J. Invest. Dermatol. 127 (5): 1107–14. doi: 10.1038/sj.jid.5700674 . PMID 17195013.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000137709 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032015 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10473598-5] Hildesheim J, Foster RA, Chamberlin ME, Vogel JC (Oct 1999). "Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor". J Biol Chem. 274 (37): 26399–406. doi: 10.1074/jbc.274.37.26399 . PMID 10473598.

[entrez-6] "Entrez Gene: POU2F3 POU domain, class 2, transcription factor 3".

[1]

[2]

[3]

[4]

[5]

[6]

POU2F3

Related Research Articles

References

Further reading