PPAP2A

PLPP1
Identifiers
Aliases	PLPP1 , LLP1a, LPP1, PAP-2a, PAP2, PPAP2A, phospholipid phosphatase 1
External IDs	OMIM: 607124; MGI: 108412; HomoloGene: 7484; GeneCards: PLPP1; OMA:PLPP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q11.2 Start 55,424,854 bp [1] End 55,534,969 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 D2.2 Start 112,937,326 bp [2] End 113,004,428 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua gallbladder prostate glomerulus metanephric glomerulus left coronary artery right coronary artery mucosa of urinary bladder abdominal fat pericardium Top expressed in seminal vesicula endothelial cell of lymphatic vessel gastrula decidua ankle right lung lobe adrenal gland semi-lunar valve molar carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidate phosphatase activity hydrolase activity sphingosine-1-phosphate phosphatase activity lipid phosphatase activity phosphatase activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome membrane Biological process androgen receptor signaling pathway phospholipid metabolic process regulation of lipid metabolic process protein dephosphorylation protein kinase C-activating G protein-coupled receptor signaling pathway intracellular steroid hormone receptor signaling pathway sphingolipid biosynthetic process germ cell migration negative regulation of cell population proliferation lipid metabolism phospholipid dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8611 19012 Ensembl ENSG00000067113 ENSMUSG00000021759 UniProt O14494 Q61469 RefSeq (mRNA) NM_003711 NM_176895 NM_008247 NM_008903 RefSeq (protein) NP_003702 NP_795714 NP_032273 NP_032929 Location (UCSC) Chr 5: 55.42 – 55.53 Mb Chr 13: 112.94 – 113 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene. ^{[5] [6]}

Function

Lipid phosphate phosphohydrolase 1 is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000067113 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021759 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kai M, Wada I, Imai S, Sakane F, Kanoh H (Oct 1997). "Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase". J Biol Chem. 272 (39): 24572–24578. doi: 10.1074/jbc.272.39.24572 . PMID   9305923.
6. "Entrez Gene: PPAP2A phosphatidic acid phosphatase type 2A".

Further reading

• Kanoh H, Kai M, Wada I (1999). "Molecular characterization of the type 2 phosphatidic acid phosphatase". Chem. Phys. Lipids. 98 (1–2): 119–126. doi:10.1016/S0009-3084(99)00024-9. PMID   10358934.
• Nanjundan M, Possmayer F (2003). "Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L1–23. doi:10.1152/ajplung.00029.2002. PMID   12471011.
• Ulrix W, Swinnen JV, Heyns W, Verhoeven G (1998). "Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic adenocarcinoma cell line LNCaP". J. Biol. Chem. 273 (8): 4660–4665. doi: 10.1074/jbc.273.8.4660 . PMID   9468526.
• Leung DW, Tompkins CK, White T (1998). "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells". DNA Cell Biol. 17 (4): 377–385. doi:10.1089/dna.1998.17.377. PMID   9570154.
• Hooks SB, Ragan SP, Lynch KR (1998). "Identification of a novel human phosphatidic acid phosphatase type 2 isoform". FEBS Lett. 427 (2): 188–192. doi:10.1016/S0014-5793(98)00421-9. PMID   9607309. S2CID   31610109.
• Roberts R, Sciorra VA, Morris AJ (1998). "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform". J. Biol. Chem. 273 (34): 22059–22067. doi: 10.1074/jbc.273.34.22059 . PMID   9705349.
• Neumann J, Maas R, Bokník P, et al. (1999). "Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts". J. Pharmacol. Exp. Ther. 289 (1): 188–93. PMID   10087003.
• Moreno CS, Park S, Nelson K, et al. (2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–5263. doi: 10.1074/jbc.275.8.5257 . PMC   3505218 . PMID   10681496.
• Roberts RZ, Morris AJ (2001). "Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators". Biochim. Biophys. Acta. 1487 (1): 33–49. doi:10.1016/s1388-1981(00)00081-0. PMID   10962286.
• Woetmann A, Brockdorff J, Lovato P, et al. (2003). "Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling". J. Biol. Chem. 278 (5): 2787–2791. doi: 10.1074/jbc.M210196200 . PMID   12426308.
• Pandey AV, Mellon SH, Miller WL (2003). "Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17". J. Biol. Chem. 278 (5): 2837–2844. doi: 10.1074/jbc.M209527200 . PMID   12444089.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Smyth SS, Sciorra VA, Sigal YJ, et al. (2003). "Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity". J. Biol. Chem. 278 (44): 43214–43223. doi: 10.1074/jbc.M306709200 . PMID   12909631.
• Tanyi JL, Hasegawa Y, Lapushin R, et al. (2004). "Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer". Clin. Cancer Res. 9 (10 Pt 1): 3534–45. PMID   14506139.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Grkovich A, Johnson CA, Buczynski MW, Dennis EA (2006). "Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent". J. Biol. Chem. 281 (44): 32978–32987. doi: 10.1074/jbc.M605935200 . PMID   16950767.
• Kai M, Sakane F, Jia YJ, et al. (2007). "Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts". J. Biochem. 140 (5): 677–686. doi:10.1093/jb/mvj195. PMID   17005594.