PPFIA4

PPFIA4
Identifiers
Aliases	PPFIA4 , PTPRF interacting protein alpha 4
External IDs	OMIM: 603145 GeneCards: PPFIA4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	203,078,740 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; cerebellar vermis; ; Brodmann area 9; ; middle temporal gyrus; ; cingulate gyrus; ; prefrontal cortex; ; nucleus accumbens; ; amygdala; ; postcentral gyrus; ; Brodmann area 10;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; presynaptic active zone ; cell surface ; cytosol ; synapse ; intracellular anatomical structure ;
Biological process	glutamate secretion ; neurotransmitter secretion ;
	Sources:Amigo / QuickGO
Orthologs
	8497
	n/a
	ENSG00000143847
	n/a
	O75335
	n/a
NM_001304331 ; NM_001304332 ; NM_015053 ; NM_001393950 ; NM_001393951 ;
	NM_001393952 ; NM_001393953 ; NM_001393954 ; NM_001393955 ; NM_001393956 ; NM_001393957 Contents Interactions ; References ; Further reading ;
	n/a
	NP_001291260 ; NP_001291261
	n/a
	Wikidata
View/Edit Human

Last updated February 23, 2023

Liprin-alpha-4 is a protein that in humans is encoded by the PPFIA4 gene.^[3]^[4]

Interactions

PPFIA4 has been shown to interact with:

Related Research Articles

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

PSD-95 also known as SAP-90 is a protein that in humans is encoded by the DLG4 gene.

Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.

Receptor-type tyrosine-protein phosphatase F is an enzyme that in humans is encoded by the PTPRF gene.

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.

This gene encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family, and is most highly similar to GRK4 and GRK5. The protein phosphorylates the activated forms of G protein-coupled receptors to regulate their signaling.

ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene.

G protein-coupled receptor kinase 5 is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases, and is most highly similar to GRK4 and GRK6. The protein phosphorylates the activated forms of G protein-coupled receptors to regulate their signaling.

ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.

Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the PTPRS gene.

Calcium channel, voltage-dependent, gamma subunit 2, also known as CACNG2 or stargazin is a protein that in humans is encoded by the CACNG2 gene.

ELKS/RAB6-interacting/CAST family member 1 is a protein that in humans is encoded by the ERC1 gene. The name ELKS is derived from "protein rich in the amino acids E, L, K and S"

Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post-synaptic density.

SH3 and multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the SHANK1 gene.

Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the PTPRD gene.

Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene.

Glutamate receptor-interacting protein 2 is a protein that in humans is encoded by the GRIP2 gene.

Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.

ERC protein 2 is a protein that in humans is encoded by the ERC2 gene.

Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143847 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–20. doi: 10.1074/jbc.273.25.15611 . PMID 9624153.
↑ "Entrez Gene: PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4".
1 2 Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID 12923177.
↑ Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi: 10.1523/JNEUROSCI.23-05-01667.2003 . PMC 6741975 . PMID 12629171.
↑ Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (Mar 2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi: 10.1016/s0896-6273(02)00640-2 . PMID 11931740. S2CID 16142847.

Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.
Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. doi:10.1016/j.bbrc.2003.10.101. PMID 14623284.
Katoh M, Katoh M (2004). "Identification and characterization of human PPFIA4 gene in silico". Int. J. Mol. Med. 12 (6): 1009–14. doi:10.3892/ijmm.12.6.1009. PMID 14612982.
Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID 12923177.
Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi: 10.1523/JNEUROSCI.23-05-01667.2003 . PMC 6741975 . PMID 12629171.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143847 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9624153-3] Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–20. doi: 10.1074/jbc.273.25.15611 . PMID 9624153.

[entrez-4] "Entrez Gene: PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4".

[pmid12923177-5] 1 2 Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID 12923177.

[pmid12629171-6] Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi: 10.1523/JNEUROSCI.23-05-01667.2003 . PMC 6741975 . PMID 12629171.

[pmid11931740-7] Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (Mar 2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi: 10.1016/s0896-6273(02)00640-2 . PMID 11931740. S2CID 16142847.

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PPFIA4

Contents

Interactions

Related Research Articles

References

Further reading