PPFIA4

PPFIA4
Identifiers
Aliases	PPFIA4 , PTPRF interacting protein alpha 4
External IDs	OMIM: 603145; GeneCards: PPFIA4; OMA:PPFIA4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 203,026,491 bp [1] End 203,078,740 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis paraflocculus of cerebellum right frontal lobe primary visual cortex Brodmann area 9 middle temporal gyrus apex of heart cingulate gyrus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm presynaptic active zone cell surface cytosol synapse intracellular anatomical structure Biological process glutamate secretion neurotransmitter secretion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8497 n/a Ensembl ENSG00000143847 n/a UniProt O75335 n/a RefSeq (mRNA) NM_001304331 NM_001304332 NM_015053 NM_001393950 NM_001393951 NM_001393952 NM_001393953 NM_001393954 NM_001393955 NM_001393956 NM_001393957 n/a RefSeq (protein) NP_001291260 NP_001291261 n/a Location (UCSC) Chr 1: 203.03 – 203.08 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Liprin-alpha-4 is a protein that in humans is encoded by the PPFIA4 gene. ^{[3] [4]}

Interactions

PPFIA4 has been shown to interact with:

• ERC2, ^[5]
• GIT1, ^{[5] [6]} and
• Nuclear receptor coactivator 2. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000143847 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–20. doi: 10.1074/jbc.273.25.15611 . PMID   9624153.
4. "Entrez Gene: PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4".
5. Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID   12923177.
6. Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi: 10.1523/JNEUROSCI.23-05-01667.2003 . PMC   6741975 . PMID   12629171.
7. Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (Mar 2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi: 10.1016/s0896-6273(02)00640-2 . PMID   11931740. S2CID   16142847.

Further reading

• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. doi:10.1016/j.bbrc.2003.10.101. PMID   14623284.
• Katoh M, Katoh M (2004). "Identification and characterization of human PPFIA4 gene in silico". Int. J. Mol. Med. 12 (6): 1009–14. doi:10.3892/ijmm.12.6.1009. PMID   14612982.
• Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID   12923177.
• Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi: 10.1523/JNEUROSCI.23-05-01667.2003 . PMC   6741975 . PMID   12629171.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.