ERC2 (gene)

ERC2
Identifiers
Aliases	ERC2 , CAST, CAST1, ELKSL, SPBC110, Spc110, ELKS/RAB6-interacting/CAST family member 2
External IDs	OMIM: 617250 MGI: 1098749 HomoloGene: 69188 GeneCards: ERC2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	56,468,467 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	28,200,494 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; orbitofrontal cortex; ; endothelial cell; ; Brodmann area 46; ; superior frontal gyrus; ; entorhinal cortex; ; postcentral gyrus; ; frontal pole; ; Brodmann area 10;
	Top expressed in
	piriform cortex; ; dentate gyrus; ; trigeminal ganglion; ; nucleus accumbens; ; olfactory tubercle; ; temporal lobe; ; amygdala; ; Region I of hippocampus proper; ; habenula; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; structural constituent of presynaptic active zone ;
Cellular component	cytoplasm ; growth cone ; presynaptic active zone ; neuron projection ; cell junction ; synapse ; cytoskeleton ; presynaptic membrane ; presynaptic active zone cytoplasmic component ; glutamatergic synapse ; GABA-ergic synapse ;
Biological process	synaptic vesicle priming ; maintenance of presynaptic active zone structure ;
	Sources:Amigo / QuickGO
Orthologs
	26059
	238988
	ENSG00000187672
	ENSMUSG00000040640
	O15083
	Q6PH08
	NM_015576
	NM_177814 ; NM_001347497
	NP_056391
NP_001334426 ; NP_808482 ; NP_001391863 ; NP_001391864 ; NP_001391865 ;
	NP_001391866
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

ERC protein 2 is a protein that in humans is encoded by the ERC2 gene.^[5]

Interactions

ERC2 (gene) has been shown to interact with PPFIA4,^[6] RIMS1,^[7]^[8] UNC13A,^[9] and liprin-alpha-1.^[6]

Related Research Articles

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Regulating synaptic membrane exocytosis protein 1 is a protein that in humans is encoded by the RIMS1 gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187672 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040640 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: ERC2 ELKS/RAB6-interacting/CAST family member 2".
1 2 Ko J, Na M, Kim S, Lee JR, Kim E (October 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". The Journal of Biological Chemistry. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID 12923177.
↑ Takao-Rikitsu E, Mochida S, Inoue E, Deguchi-Tawarada M, Inoue M, Ohtsuka T, Takai Y (January 2004). "Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release". The Journal of Cell Biology. 164 (2): 301–11. doi:10.1083/jcb.200307101. PMC 2172332 . PMID 14734538.
↑ Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". The Journal of Cell Biology. 158 (3): 577–90. doi:10.1083/jcb.200202083. PMC 2173811 . PMID 12163476.
↑ "Protein unc-13 homolog A". UniProt.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923 . doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID 9205841.
Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". The Journal of Cell Biology. 158 (3): 577–90. doi:10.1083/jcb.200202083. PMC 2173811 . PMID 12163476.
Wang Y, Liu X, Biederer T, Südhof TC (October 2002). "A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones". Proceedings of the National Academy of Sciences of the United States of America. 99 (22): 14464–9. Bibcode:2002PNAS...9914464W. doi: 10.1073/pnas.182532999 . PMC 137906 . PMID 12391317.
Ko J, Na M, Kim S, Lee JR, Kim E (October 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". The Journal of Biological Chemistry. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID 12923177.
Deguchi-Tawarada M, Inoue E, Takao-Rikitsu E, Inoue M, Ohtsuka T, Takai Y (January 2004). "CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST". Genes to Cells. 9 (1): 15–23. doi: 10.1111/j.1356-9597.2004.00697.x . PMID 14723704. S2CID 13337267.
Takao-Rikitsu E, Mochida S, Inoue E, Deguchi-Tawarada M, Inoue M, Ohtsuka T, Takai Y (January 2004). "Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release". The Journal of Cell Biology. 164 (2): 301–11. doi:10.1083/jcb.200307101. PMC 2172332 . PMID 14734538.
tom Dieck S, Altrock WD, Kessels MM, Qualmann B, Regus H, Brauner D, Fejtová A, Bracko O, Gundelfinger ED, Brandstätter JH (February 2005). "Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex". The Journal of Cell Biology. 168 (5): 825–36. doi:10.1083/jcb.200408157. PMC 2171818 . PMID 15728193.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187672 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040640 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ERC2 ELKS/RAB6-interacting/CAST family member 2".

[pmid12923177-6] 1 2 Ko J, Na M, Kim S, Lee JR, Kim E (October 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". The Journal of Biological Chemistry. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID 12923177.

[pmid14734538-7] Takao-Rikitsu E, Mochida S, Inoue E, Deguchi-Tawarada M, Inoue M, Ohtsuka T, Takai Y (January 2004). "Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release". The Journal of Cell Biology. 164 (2): 301–11. doi:10.1083/jcb.200307101. PMC 2172332 . PMID 14734538.

[pmid12163476-8] Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". The Journal of Cell Biology. 158 (3): 577–90. doi:10.1083/jcb.200202083. PMC 2173811 . PMID 12163476.

[9] "Protein unc-13 homolog A". UniProt.

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ERC2 (gene)

Contents

Interactions

Related Research Articles

References

Further reading