Regulating synaptic membrane exocytosis protein 1 is a protein that in humans is encoded by the RIMS1 gene. [3] [4] [5]
RAB3A (MIM 179490), a member of the Ras superfamily of genes, is a synaptic vesicle protein that regulates synaptic vesicle exocytosis. MUNC13 (UNC13; MIM 605836) and its isoforms are required for priming synaptic vesicles for exocytosis. The RIM family of active zone proteins likely function as protein scaffolds that help regulate vesicle exocytosis during short-term plasticity.[supplied by OMIM] [5]
Mutations of the gene cause cone-rod dystrophy 7.
RIMS1 has been shown to interact with:
Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.
Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene. It is involved in calcium-triggered exocytosis in neurons.
Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene.
Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.
Syntaxin-binding protein 1 is a protein that in humans is encoded by the STXBP1 gene. This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4.
Amyloid beta A4 precursor protein-binding family A member 2 is a protein that in humans is encoded by the APBA2 gene.
Rabphilin-3A is a protein that in humans is encoded by the RPH3A gene. It contains two C2 domains and binds calcium ions at low micromolar concentration. Rabphilin was shown to regulate neurotransmitter release in hippocampal neurons after neurons had an increased synaptic activity and their release rate was depressed.
ELKS/RAB6-interacting/CAST family member 1 is a protein that in humans is encoded by the ERC1 gene. The name ELKS is derived from "protein rich in the amino acids E, L, K and S"
Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.
Protein unc-13 homolog B is a protein that in humans is encoded by the UNC13B gene.
Synaptotagmin-like protein 4 is a protein that in humans is encoded by the SYTL4 gene.
Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene.
DnaJ homolog subfamily C member 5, also known as cysteine string protein or CSP is a protein, that in humans encoded by the DNAJC5 gene. It was first described in 1990.
Regulating synaptic membrane exocytosis protein 2 is a protein that in humans is encoded by the RIMS2 gene.
BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.
ERC protein 2 is a protein that in humans is encoded by the ERC2 gene.
Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.
Double C2-like domain-containing protein beta is a protein that in humans is encoded by the DOC2B gene.
BR serine/threonine kinase 1 is an enzyme that in humans is encoded by the BRSK1 gene.
Unc-13 homolog A is a protein that in humans is encoded by the UNC13A gene.