PPFIBP1

PPFIBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TAD
Identifiers
Aliases	PPFIBP1 , L2, SGT2, hSGT2, hSgt2p, PPFIA binding protein 1
External IDs	OMIM: 603141 MGI: 1914783 HomoloGene: 2685 GeneCards: PPFIBP1
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p11.23-p11.22 Start 27,523,431 bp [1] End 27,695,564 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G3 Start 146,789,985 bp [2] End 146,933,523 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon trigeminal ganglion ventricle left ventricle right ventricle nipple spinal ganglia pericardium ascending aorta Top expressed in cumulus cell hand otolith organ utricle cervix conjunctival fornix seminal vesicula semi-lunar valve esophagus aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cadherin binding Cellular component plasma membrane focal adhesion cytosol Biological process cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8496 67533 Ensembl ENSG00000110841 ENSMUSG00000016487 UniProt Q86W92 Q8C8U0 RefSeq (mRNA) NM_001198915 NM_001198916 NM_003622 NM_177444 NM_001170433 NM_026221 NM_001355728 NM_001355729 RefSeq (protein) NP_001185844 NP_001185845 NP_003613 NP_803193 NP_001163904 NP_080497 NP_001342657 NP_001342658 Location (UCSC) Chr 12: 27.52 – 27.7 Mb Chr 6: 146.79 – 146.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene. ^{[5] [6] [7]}

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. ^[7]

Interactions

PPFIBP1 has been shown to interact with liprin-alpha-1. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000110841 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000016487 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Serra-Pages C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–20. doi: 10.1074/jbc.273.25.15611 . PMID   9624153.
6. Kriajevska M, Fischer-Larsen M, Moertz E, Vorm O, Tulchinsky E, Grigorian M, Ambartsumian N, Lukanidin E (Feb 2002). "Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1)". J Biol Chem. 277 (7): 5229–35. doi: 10.1074/jbc.M110976200 . PMID   11836260.
7. "Entrez Gene: PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. CiteSeerX   10.1.1.323.5263 . doi:10.1016/j.cub.2004.07.051. PMID   15324660. S2CID   2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.