PPIL2

PPIL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZKC
Identifiers
Aliases	PPIL2 , CYC4, CYP60, Cyp-60, UBOX7, hCyP-60, peptidylprolyl isomerase like 2
External IDs	OMIM: 607588; MGI: 2447857; HomoloGene: 8643; GeneCards: PPIL2; OMA:PPIL2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q11.21-q11.22 Start 21,666,000 bp [1] End 21,700,015 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 A3 Start 16,904,419 bp [2] End 16,929,121 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland granulocyte body of pancreas gastric mucosa minor salivary glands apex of heart body of stomach nipple anterior pituitary Top expressed in spermatocyte spermatid genital tubercle tail of embryo ventricular zone thymus neural layer of retina neural tube right kidney granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-ubiquitin ligase activity protein binding isomerase activity ubiquitin protein ligase activity ubiquitin-protein transferase activity transferase activity peptidyl-prolyl cis-trans isomerase activity cyclosporin A binding Cellular component cytoplasm Golgi lumen plasma membrane nucleus nucleoplasm Biological process protein polyubiquitination protein localization to plasma membrane protein folding protein ubiquitination leukocyte migration protein peptidyl-prolyl isomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23759 66053 Ensembl ENSG00000100023 ENSMUSG00000022771 UniProt Q13356 Q9D787 RefSeq (mRNA) NM_014337 NM_148175 NM_148176 NM_001317996 NM_001252444 NM_001252445 NM_144954 NM_001356386 RefSeq (protein) NP_001304925 NP_055152 NP_680480 NP_680481 NP_001239373 NP_001239374 NP_659203 NP_001343315 Location (UCSC) Chr 22: 21.67 – 21.7 Mb Chr 16: 16.9 – 16.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 2 is an enzyme that in humans is encoded by the PPIL2 gene. ^{[5] [6]}

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000100023 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022771 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
6. "Entrez Gene: PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2".

Further reading

• Wang BB, Hayenga KJ, Payan DG, Fisher JM (1996). "Identification of a nuclear-specific cyclophilin which interacts with the proteinase inhibitor eglin c". Biochem. J. 314 (1): 313–9. doi:10.1042/bj3140313. PMC   1217042 . PMID   8660300.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Pushkarsky T, Yurchenko V, Vanpouille C, et al. (2005). "Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60". J. Biol. Chem. 280 (30): 27866–71. doi: 10.1074/jbc.M503770200 . PMID   15946952.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Davis TL, Walker JR, Campagna-Slater V, et al. (2010). "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases". PLOS Biol. 8 (7): e1000439. doi: 10.1371/journal.pbio.1000439 . PMC   2911226 . PMID   20676357.