PPIL4

PPIL4
Identifiers
Aliases	PPIL4 , HDCME13P, peptidylprolyl isomerase like 4
External IDs	OMIM: 607609; MGI: 1914668; HomoloGene: 12126; GeneCards: PPIL4; OMA:PPIL4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q25.1 Start 149,504,495 bp [1] End 149,546,043 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A1 Start 7,668,655 bp [2] End 7,698,899 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon testicle left ovary gonad ventricular zone right ovary endometrium islet of Langerhans thymus Top expressed in saccule otic vesicle otic placode zygote primitive streak granulocyte pituitary gland seminal vesicula neural layer of retina blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function isomerase activity nucleic acid binding RNA binding peptidyl-prolyl cis-trans isomerase activity Cellular component nucleus nucleoplasm cytosol Biological process protein peptidyl-prolyl isomerization regulation of phosphorylation of RNA polymerase II C-terminal domain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85313 67418 Ensembl ENSG00000131013 ENSMUSG00000015757 UniProt Q8WUA2 Q9CXG3 RefSeq (mRNA) NM_139126 NM_026141 RefSeq (protein) NP_624311 NP_080417 Location (UCSC) Chr 6: 149.5 – 149.55 Mb Chr 10: 7.67 – 7.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase-like 4 is an enzyme that in humans is encoded by the PPIL4 gene. ^[5]

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000131013 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015757 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4".

Further reading

• Zeng L, Zhou Z, Xu J, et al. (2002). "Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain". Cytogenet. Cell Genet. 95 (1–2): 43–7. doi:10.1159/000057015. PMID   11978968. S2CID   35018873.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID   12747765.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.