PPP1R3C

PPP1R3C
Identifiers
Aliases	PPP1R3C , PPP1R5, protein phosphatase 1 regulatory subunit 3C, PTG
External IDs	OMIM: 602999 MGI: 1858229 HomoloGene: 3938 GeneCards: PPP1R3C
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q23.32 Start 91,628,442 bp [1] End 91,633,071 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C2 Start 36,709,131 bp [2] End 36,714,053 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vastus lateralis muscle triceps brachii muscle body of tongue deltoid muscle tibialis anterior muscle vena cava saphenous vein Achilles tendon thoracic diaphragm myocardium Top expressed in sternocleidomastoid muscle triceps brachii muscle digastric muscle intercostal muscle temporal muscle vastus lateralis muscle left lung lobe atrioventricular valve endocardial cushion atrium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine phosphatase activity protein phosphatase regulator activity protein binding protein phosphatase binding Cellular component cytosol Biological process protein dephosphorylation glycogen biosynthetic process glycogen metabolic process carbohydrate metabolic process regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5507 53412 Ensembl ENSG00000119938 ENSMUSG00000067279 UniProt Q9UQK1 Q7TMB3 RefSeq (mRNA) NM_005398 NM_016854 RefSeq (protein) NP_005389 NP_058550 Location (UCSC) Chr 10: 91.63 – 91.63 Mb Chr 19: 36.71 – 36.71 Mb PubMed search [3] [4]
Wikidata
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Protein phosphatase 1 regulatory subunit 3C also known as PTG is an enzyme that in humans is encoded by the PPP1R3C gene. ^{[5] [6]}

Function

Protein phosphatase-1 (PP1) participates in the regulation of a wide variety of cellular functions by reversible protein phosphorylation. The ability of PP1 to regulate diverse functions resides in its capacity to interact with a variety of regulatory subunits that may target PP1 to specific subcellular locations, modulate its substrate specificity, and allow its activity to be responsive to extracellular signals. Several targeting subunits of PP1 have been identified, including PPP1R5, the glycogen-binding subunits G_M, G_L, PTG and R6 and PPP1R4, and the nuclear inhibitor of PP1 (PPP1R8). ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000119938 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067279 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Doherty MJ, Young PR, Cohen PT (Jan 1997). "Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1". FEBS Lett. 399 (3): 339–43. doi:10.1016/S0014-5793(96)01357-9. PMID   8985175. S2CID   31243700.
6. "Entrez Gene: PPP1R3C protein phosphatase 1, regulatory (inhibitor) subunit 3C".

Further reading

• Armstrong CG, Browne GJ, Cohen P, Cohen PT (1998). "PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1". FEBS Lett. 418 (1–2): 210–4. doi:10.1016/S0014-5793(97)01385-9. PMID   9414128. S2CID   21169749.
• Permana PA, Luczy-Bachman G, Bogardus C (1999). "Protein targeting to glycogen/PPP1R5: screening of coding and flanking genomic regions for polymorphisms and association analysis with insulin action in Pima Indians". Biochem. Biophys. Res. Commun. 258 (1): 184–6. doi:10.1006/bbrc.1999.0614. PMID   10222257.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.