PPP2R2D

PPP2R2D
Identifiers
Aliases	PPP2R2D , MDS026, protein phosphatase 2 regulatory subunit Bdelta, B55delta, B55D
External IDs	OMIM: 613992 MGI: 1289252 HomoloGene: 81915 GeneCards: PPP2R2D
Gene location (Human)
Chr.	Chromosome 10 (human)
End	131,959,834 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	138,883,057 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; cerebellar hemisphere; ; Left adrenal gland; ; ganglionic eminence; ; anterior pituitary; ; prefrontal cortex; ; Achilles tendon; ; Brodmann area 23; ; gastrocnemius muscle; ; left ventricle;
	Top expressed in
	internal carotid artery; ; facial motor nucleus; ; external carotid artery; ; seminiferous tubule; ; primitive streak; ; right ventricle; ; spermatid; ; brown adipose tissue; ; motor neuron; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein serine/threonine phosphatase activity ; protein binding ; protein phosphatase regulator activity ;
Cellular component	cytoplasm ; protein phosphatase type 2A complex ; cytosol ;
Biological process	cell division ; cell cycle ; exit from mitosis ; peptidyl-serine dephosphorylation ; mitotic cell cycle ; developmental process ; regulation of phosphoprotein phosphatase activity ;
	Sources:Amigo / QuickGO
Orthologs
	55844
	52432
	ENSG00000175470
	ENSMUSG00000041769
	Q66LE6
	Q925E7
	NM_001003656 ; NM_001291310 ; NM_018461
	NM_026391 ; NM_001347618
	NP_001278239 ; NP_060931
	NP_001334547 ; NP_080667
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

PP2A subunit B isoform delta also known as serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform is a protein that in humans is encoded by the PPP2R2D gene.^[5] It is a regulatory subunit of the heterotrimeric protein phosphatase 2 enzyme.

Related Research Articles

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the PPP2R5A gene.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the PPP2R2A gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the PPP2R1B gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene. Mutations in PPP2R5D cause Jordan's Syndrome.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.

Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the IGBP1 gene.

Coatomer subunit zeta-1 is a protein that in humans is encoded by the COPZ1 gene.

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PP2BC) is an enzyme that in humans is encoded by the PPP3CC gene.

Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene. Among its related pathways are MAPK signaling pathway and GPCR pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.

Pyruvate dehydrogenase phosphatase regulatory subunit is a protein that in humans is encoded by the PDPR gene.

Protein phosphatase 1 regulatory subunit 12C is a protein that in humans is encoded by the PPP1R12C gene.

Myotubularin related protein 12 is a protein that in humans is encoded by the MTMR12 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000175470 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041769 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Protein phosphatase 2 regulatory subunit Bdelta".

PPP2R2D

Related Research Articles

References

Further reading