PPP2R5B

PPP2R5B
Identifiers
Aliases	PPP2R5B , B56B, PR61B, protein phosphatase 2 regulatory subunit B'beta, B56beta
External IDs	OMIM: 601644; MGI: 2388480; HomoloGene: 38157; GeneCards: PPP2R5B; OMA:PPP2R5B - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.1 Start 64,917,553 bp [1] End 64,934,475 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 6,277,795 bp [2] End 6,285,902 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum paraflocculus of cerebellum pons right frontal lobe prefrontal cortex cerebellar vermis dorsal motor nucleus of vagus nerve nucleus accumbens lateral nuclear group of thalamus cingulate gyrus Top expressed in adrenal gland cerebellum cerebellar cortex olfactory bulb striatum of neuraxis superior frontal gyrus hypothalamus primary visual cortex bone marrow hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein phosphatase regulator activity protein phosphatase activator activity Cellular component cytosol protein phosphatase type 2A complex cytoplasm nucleus Biological process regulation of protein autophosphorylation positive regulation of DNA-binding transcription factor activity IRE1-mediated unfolded protein response negative regulation of G0 to G1 transition positive regulation of neurotrophin TRK receptor signaling pathway positive regulation of neuron projection development positive regulation of protein-containing complex assembly regulation of peptidyl-tyrosine phosphorylation positive regulation of transcription by RNA polymerase II signal transduction regulation of signaling receptor activity cellular response to growth factor stimulus regulation of protein phosphorylation regulation of phosphatidylinositol 3-kinase signaling regulation of phosphoprotein phosphatase activity protein dephosphorylation negative regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5526 225849 Ensembl ENSG00000068971 ENSMUSG00000024777 UniProt Q15173 Q6PD28 RefSeq (mRNA) NM_006244 NM_198168 RefSeq (protein) NP_006235 NP_937811 Location (UCSC) Chr 11: 64.92 – 64.93 Mb Chr 19: 6.28 – 6.29 Mb PubMed search [3] [4]
Wikidata
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Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene. ^{[5] [6]}

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. ^[6]

Interactions

PPP2R5B has been shown to interact with PPP2R1B ^[7] and PPP2CA. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000068971 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024777 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry. 270 (44): 26123–8. doi: 10.1074/jbc.270.44.26123 . PMID   7592815.
6. "Entrez Gene: PPP2R5B protein phosphatase 2, regulatory subunit B', beta isoform".
7. McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi: 10.1074/jbc.271.36.22081 . PMID   8703017.
8. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi: 10.1074/mcp.M800266-MCP200 . PMC   2621004 . PMID   18782753.

Further reading

• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi: 10.1186/1742-4690-2-11 . PMC   554975 . PMID   15725353.
• Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi: 10.1038/sj.cr.7290279 . PMID   15780175.
• Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID   15817944.
• Cross SH, Charlton JA, Nan X, Bird AP (Mar 1994). "Purification of CpG islands using a methylated DNA binding column". Nature Genetics. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID   8012384. S2CID   12847618.
• Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA (Jul 1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". The Biochemical Journal. 317 (1): 187–94. doi:10.1042/bj3170187. PMC   1217462 . PMID   8694763.
• McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi: 10.1074/jbc.271.36.22081 . PMID   8703017.
• McCright B, Brothman AR, Virshup DM (Aug 1996). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics. 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID   8812429.
• Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2–3): 197–201. Bibcode:1997FEBSL.401..197T. doi: 10.1016/S0014-5793(96)01470-6 . PMID   9013886. S2CID   23293768.
• Forbes SA, Pannett AA, Bassett JH, Harding B, Wooding C, Thakker RV, Butler R, Ogilvie D, Anand R, Gaudray P, Weber G, Larsson C, Zhang CX, Calender A, Höppener JW, Lips CJ, Kas K (Sep 1997). "Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1)". Human Genetics. 100 (3–4): 481–5. doi:10.1007/s004390050538. PMID   9272177. S2CID   11988533.
• Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi: 10.1006/viro.1997.8873 . PMID   9400615.
• Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A (Jan 2000). "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin". Oncogene. 19 (4): 537–45. doi: 10.1038/sj.onc.1203359 . PMID   10698523.
• Hrimech M, Yao XJ, Branton PE, Cohen EA (Aug 2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". The EMBO Journal. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMC   306605 . PMID   10921877. (Retracted, see doi:10.1093/emboj/cdf420, PMID   12110603)
• Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi: 10.1006/viro.2001.1007 . PMID   11531413.
• Hrimech M, Yao XJ, Branton PE, Cohen EA (Jul 2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". The EMBO Journal. 21 (14): 3918. doi:10.1093/emboj/cdf420. PMC   126131 . PMID   12110603.
• Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A (Jun 2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". Journal of Neurovirology. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID   12775419. S2CID   22016092.
• Dozier C, Bonyadi M, Baricault L, Tonasso L, Darbon JM (Sep 2004). "Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit". Biology of the Cell. 96 (7): 509–17. doi: 10.1016/j.biolcel.2004.04.010 . PMID   15380617. S2CID   41084828.