PPP2R5B

Last updated
PPP2R5B
Identifiers
Aliases PPP2R5B , B56B, PR61B, protein phosphatase 2 regulatory subunit B'beta, B56beta
External IDs OMIM: 601644 MGI: 2388480 HomoloGene: 38157 GeneCards: PPP2R5B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006244

NM_198168

RefSeq (protein)

NP_006235

NP_937811

Location (UCSC) Chr 11: 64.92 – 64.93 Mb Chr 19: 6.28 – 6.29 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene. [5] [6]

Contents

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [6]

Interactions

PPP2R5B has been shown to interact with PPP2R1B [7] and PPP2CA. [7] [8]

Related Research Articles

<span class="mw-page-title-main">PPP2CA</span> Enzyme

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that is encoded by the PPP2CA gene.

<span class="mw-page-title-main">Wee1-like protein kinase</span> Protein-coding gene in the species Homo sapiens

WEE1 homolog , also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.

<span class="mw-page-title-main">PPP2R1A</span> Enzyme

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).

<span class="mw-page-title-main">PPP2R2B</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

<span class="mw-page-title-main">COPS6</span> Protein-coding gene in humans

COP9 signalosome complex subunit 6 is a protein that in humans is encoded by the COPS6 gene.

<span class="mw-page-title-main">PPP2CB</span> Enzyme found in humans

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.

<span class="mw-page-title-main">PPP2R5A</span> Enzyme found in humans

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the PPP2R5A gene.

<span class="mw-page-title-main">Cyclin B2</span> Protein-coding gene in the species Homo sapiens

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

<span class="mw-page-title-main">PPP2R2A</span> Enzyme found in humans

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the PPP2R2A gene.

<span class="mw-page-title-main">PPP2R5C</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.

<span class="mw-page-title-main">PPP2R4</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.

<span class="mw-page-title-main">PPP2R1B</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the PPP2R1B gene.

<span class="mw-page-title-main">PPP2R3A</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

<span class="mw-page-title-main">PPP2R5D</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene. Mutations in PPP2R5D cause Jordan's Syndrome.

<span class="mw-page-title-main">PPP2R2C</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.

<span class="mw-page-title-main">PPP2R5E</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.

<span class="mw-page-title-main">PPP2R3B</span> Protein-coding gene in humans

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta is an enzyme that in humans is encoded by the PPP2R3B gene.

<span class="mw-page-title-main">Protein phosphatase 2</span> Class of enzyme complexes

Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. Its serine/threonine phosphatase activity has a broad substrate specificity and diverse cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT, where PP2A may act as a tumor suppressor.

<span class="mw-page-title-main">B56 domain</span>

Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. Phosphorylation enables the activation or The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits, this family is called the B56 family.

<span class="mw-page-title-main">PPP2R2D</span> Protein-coding gene in the species Homo sapiens

PP2A subunit B isoform delta also known as serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform is a protein that in humans is encoded by the PPP2R2D gene. It is a regulatory subunit of the heterotrimeric protein phosphatase 2 enzyme.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000068971 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024777 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry. 270 (44): 26123–8. doi: 10.1074/jbc.270.44.26123 . PMID   7592815.
  6. 1 2 "Entrez Gene: PPP2R5B protein phosphatase 2, regulatory subunit B', beta isoform".
  7. 1 2 McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi: 10.1074/jbc.271.36.22081 . PMID   8703017.
  8. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi: 10.1074/mcp.M800266-MCP200 . PMC   2621004 . PMID   18782753.

Further reading