PPP3R1

PPP3R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AUI, 1M63, 1MF8, 2P6B, 3LL8, 4F0Z, 4OR9, 4ORA, 4ORC, 4ORB
Identifiers
Aliases	PPP3R1 , CALNB1, CNB, CNB1, protein phosphatase 3 regulatory subunit B, alpha
External IDs	OMIM: 601302; MGI: 107172; HomoloGene: 68099; GeneCards: PPP3R1; OMA:PPP3R1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p14 Start 68,178,857 bp [1] End 68,256,237 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A2 Start 17,109,263 bp [2] End 17,150,375 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 9 nucleus accumbens Achilles tendon right frontal lobe monocyte caudate nucleus prefrontal cortex putamen cerebellar hemisphere amygdala Top expressed in CA3 field perirhinal cortex Region I of hippocampus proper olfactory tubercle entorhinal cortex dentate gyrus prefrontal cortex primary motor cortex primary visual cortex superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding protein domain specific binding metal ion binding calmodulin binding protein binding calcium-dependent protein serine/threonine phosphatase activity cyclosporin A binding phosphoprotein phosphatase activity phosphatase binding Cellular component cytoplasm cytosol membrane plasma membrane nucleoplasm sarcolemma calcineurin complex mitochondrion Biological process Fc-epsilon receptor signaling pathway positive regulation of transcription by RNA polymerase II protein dephosphorylation Wnt signaling pathway, calcium modulating pathway branching involved in blood vessel morphogenesis epithelial to mesenchymal transition heart development Schwann cell development myelination in peripheral nervous system calcineurin-NFAT signaling cascade protein localization to nucleus lung epithelial cell differentiation protein import into nucleus positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5534 19058 Ensembl ENSG00000221823 ENSMUSG00000033953 UniProt P63098 Q63810 RefSeq (mRNA) NM_000945 NM_024459 RefSeq (protein) NP_000936 NP_077779 Location (UCSC) Chr 2: 68.18 – 68.26 Mb Chr 11: 17.11 – 17.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene. ^{[5] [6] [7]}

Clinical significance

The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000221823 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033953 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang MG, Yi H, Guerini D, Klee CB, McBride OW (Jan 1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet Cell Genet. 72 (2–3): 236–41. doi:10.1159/000134198. PMID   8978785.
6. Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID   2558868.
7. "Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform".
8. Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, et al. (2010). Myers AJ (ed.). "SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease". PLOS Genet. 6 (9): e1001101. doi: 10.1371/journal.pgen.1001101 . PMC   2940763 . PMID   20862329.

Further reading

• Kawamura A, Su MS (1995). "Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain". J. Biol. Chem. 270 (26): 15463–6. doi: 10.1074/jbc.270.26.15463 . PMID   7541044.
• Kissinger CR, Parge HE, Knighton DR, et al. (1996). "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex". Nature. 378 (6557): 641–4. Bibcode:1995Natur.378..641K. doi:10.1038/378641a0. PMID   8524402. S2CID   4337105.
• Feng B, Stemmer PM (1999). "Interactions of calcineurin A, calcineurin B, and Ca2+". Biochemistry. 38 (38): 12481–9. doi:10.1021/bi990492w. PMID   10493818.
• Stratakis CA, Taymans SE (1999). "Structure of the gene coding for calcineurin B (PPP3R1) and mapping to D2S358-D2S1778 (chromosomal region 2p15)". DNA Seq. 9 (4): 227–30. doi:10.3109/10425179809105209. PMID   10520753.
• Nishio H, Matsui K, Tsuji H, et al. (2000). "Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis". Histochem. Cell Biol. 114 (1): 9–14. doi:10.1007/s004180000168. PMID   10959817. S2CID   21530150.
• Sokal I, Li N, Verlinde CL, et al. (2001). "Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1)". Biochim. Biophys. Acta. 1498 (2–3): 233–51. doi: 10.1016/S0167-4889(00)00099-9 . PMID   11108966.
• Graef IA, Chen F, Chen L, et al. (2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature". Cell. 105 (7): 863–75. doi: 10.1016/S0092-8674(01)00396-8 . PMID   11439183. S2CID   5278706.
• Al-Daraji WI, Grant KR, Ryan K, et al. (2002). "Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A." J. Invest. Dermatol. 118 (5): 779–88. doi: 10.1046/j.1523-1747.2002.01709.x . PMID   11982754.
• Huai Q, Kim HY, Liu Y, et al. (2002). "Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12037–42. Bibcode:2002PNAS...9912037H. doi: 10.1073/pnas.192206699 . PMC   129394 . PMID   12218175.
• Jin L, Harrison SC (2002). "Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13522–6. Bibcode:2002PNAS...9913522J. doi: 10.1073/pnas.212504399 . PMC   129706 . PMID   12357034.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi: 10.1006/viro.2002.1676 . PMID   12482669.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Bittinger MA, McWhinnie E, Meltzer J, et al. (2005). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins". Curr. Biol. 14 (23): 2156–61. doi: 10.1016/j.cub.2004.11.002 . PMID   15589160. S2CID   5934014.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Winslow MM, Gallo EM, Neilson JR, Crabtree GR (2006). "The calcineurin phosphatase complex modulates immunogenic B cell responses". Immunity. 24 (2): 141–52. doi: 10.1016/j.immuni.2005.12.013 . PMID   16473827.
• Liu Q, Wilkins BJ, Lee YJ, et al. (2006). "Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth". Mol. Cell. Biol. 26 (10): 3785–97. doi:10.1128/MCB.26.10.3785-3797.2006. PMC   1489013 . PMID   16648474.