PPP3R2

PPP3R2
Identifiers
Aliases	PPP3R2 , PPP3RL, protein phosphatase 3 regulatory subunit B, beta
External IDs	OMIM: 613821 MGI: 107171 HomoloGene: 133815 GeneCards: PPP3R2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	101,595,021 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	49,682,024 bp
RNA expression pattern
	Top expressed in
	sperm; ; muscular system; ; muscle organ; ; right coronary artery; ; gastrocnemius muscle; ; right uterine tube; ; prefrontal cortex; ; popliteal artery; ; male reproductive gland; ; prostate;
	Top expressed in
	seminiferous tubule; ; spermatocyte; ; spermatid; ; pancreas; ; islet of Langerhans; ; hypothalamus; ; cerebral cortex; ; nucleus of brain; ; hippocampus proper; ; mesencephalon;
	More reference expression data
	n/a
Orthologs
	5535
	19059
	ENSG00000188386
	ENSMUSG00000028310
	Q96LZ3
	Q63811
	NM_147180
	NM_001004025
	NP_671709
	NP_001004025
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene.^[5]^[6] Among its related pathways are MAPK signaling pathway ^[7] and GPCR pathway.^[8] GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.^[9]

Related Research Articles

Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase. It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of the T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which include ciclosporin, voclosporin, pimecrolimus and tacrolimus.

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that is encoded by the PPP2CA gene.

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.

Glucose-6-phosphatase, catalytic subunit is an enzyme that in humans is encoded by the G6PC gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.

Protein phosphatase 1 regulatory subunit 15A also known as growth arrest and DNA damage-inducible protein GADD34 is a protein that in humans is encoded by the PPP1R15A gene.

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene.

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.

Serine/threonine protein kinase NLK is an enzyme that in humans is encoded by the NLK gene. Its name is an abbreviation for Nemo-Like Kinase, Nemo (nmo) being the Drosophila ortholog of the mammalian NLK gene. This enzyme is a member of the Mitogen-activated protein kinase (MAPK) family, although not explicitly designated as such. It is a highly divergent, atypical member of the MAPK group, lacking most features so characteristic of most mitogen-activated protein kinases. Its activation mechanism and downstream targets are still not well characterized.

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.

Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.

Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.

Protein phosphatase 1 regulatory subunit 3C also known as PTG is an enzyme that in humans is encoded by the PPP1R3C gene.

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PP2BC) is an enzyme that in humans is encoded by the PPP3CC gene.

Dual specificity protein phosphatase 18 is an enzyme that is encoded by the DUSP18 gene in humans.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188386 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028310 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liu L, Zhang J, Yuan J, Dang Y, Yang C, Chen X, Xu J, Yu L (May 2005). "Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis". Mol Biol Rep. 32 (1): 41–5. doi:10.1007/s11033-004-4250-4. PMID 15865209. S2CID 43848098.
↑ "Entrez Gene: PPP3R2 protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform".
↑ "PathCards :: MAPK signaling pathway Pathway and related pathways". pathcards.genecards.org. Retrieved 2015-09-08.
↑ "PathCards :: GPCR Pathway Pathway and related pathways". pathcards.genecards.org. Retrieved 2015-09-08.
↑ Database, GeneCards Human Gene. "PPP3R2 Gene - GeneCards | CANB2 Protein | CANB2 Antibody". www.genecards.org. Retrieved 2015-09-08.

Mukai H, Chang CD, Tanaka H, et al. (1991). "cDNA cloning of a novel testis-specific calcineurin B-like protein". Biochem. Biophys. Res. Commun. 179 (3): 1325–30. doi:10.1016/0006-291X(91)91718-R. PMID 1718268.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi: 10.1006/viro.2002.1676 . PMID 12482669.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Koefoed-Nielsen PB, Karamperis N, Højskov C, et al. (2007). "The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients". Transpl. Int. 19 (10): 821–7. doi:10.1111/j.1432-2277.2006.00359.x. PMID 16961774. S2CID 1891740.
Saeki M, Irie Y, Ni L, et al. (2007). "Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation". J. Biol. Chem. 282 (16): 11786–94. doi: 10.1074/jbc.M609347200 . PMID 17324936.
Jang H, Cho EJ, Youn HD (2007). "A new calcineurin inhibition domain in Cabin1". Biochem. Biophys. Res. Commun. 359 (1): 129–35. doi:10.1016/j.bbrc.2007.05.066. PMID 17531200.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000188386 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028310 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15865209-5] Liu L, Zhang J, Yuan J, Dang Y, Yang C, Chen X, Xu J, Yu L (May 2005). "Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis". Mol Biol Rep. 32 (1): 41–5. doi:10.1007/s11033-004-4250-4. PMID 15865209. S2CID 43848098.

[entrez-6] "Entrez Gene: PPP3R2 protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform".

[7] "PathCards :: MAPK signaling pathway Pathway and related pathways". pathcards.genecards.org. Retrieved 2015-09-08.

[8] "PathCards :: GPCR Pathway Pathway and related pathways". pathcards.genecards.org. Retrieved 2015-09-08.

[9] Database, GeneCards Human Gene. "PPP3R2 Gene - GeneCards | CANB2 Protein | CANB2 Antibody". www.genecards.org. Retrieved 2015-09-08.

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PPP3R2

Related Research Articles

References

Further reading