PPP3R2

PPP3R2
Identifiers
Aliases	PPP3R2 , PPP3RL, protein phosphatase 3 regulatory subunit B, beta
External IDs	OMIM: 613821; MGI: 107171; HomoloGene: 133815; GeneCards: PPP3R2; OMA:PPP3R2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q31.1 Start 101,591,604 bp [1] End 101,595,021 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 B1 Start 49,678,747 bp [2] End 49,682,024 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis testicle muscular system muscle skeletal muscle lower limb muscles right coronary artery muscle of leg Top expressed in seminiferous tubule spermatocyte spermatid embryo pancreas islet of Langerhans hypothalamus cerebral cortex nucleus of brain hippocampus proper More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 5535 19059 Ensembl ENSG00000188386 ENSMUSG00000028310 UniProt Q96LZ3 Q63811 RefSeq (mRNA) NM_147180 NM_001004025 RefSeq (protein) NP_671709 NP_001004025 Location (UCSC) Chr 9: 101.59 – 101.6 Mb Chr 4: 49.68 – 49.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene. ^{[5] [6]} Among its related pathways are MAPK signaling pathway ^[7] and GPCR pathway. ^[8] GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000188386 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028310 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu L, Zhang J, Yuan J, Dang Y, Yang C, Chen X, Xu J, Yu L (May 2005). "Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis". Mol Biol Rep. 32 (1): 41–5. doi:10.1007/s11033-004-4250-4. PMID   15865209. S2CID   43848098.
6. "Entrez Gene: PPP3R2 protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform".
7. "PathCards :: MAPK signaling pathway Pathway and related pathways". pathcards.genecards.org. Retrieved 2015-09-08.
8. "PathCards :: GPCR Pathway Pathway and related pathways". pathcards.genecards.org. Retrieved 2015-09-08.
9. Database, GeneCards Human Gene. "PPP3R2 Gene - GeneCards | CANB2 Protein | CANB2 Antibody". www.genecards.org. Retrieved 2015-09-08.

Further reading

• Mukai H, Chang CD, Tanaka H, et al. (1991). "cDNA cloning of a novel testis-specific calcineurin B-like protein". Biochem. Biophys. Res. Commun. 179 (3): 1325–30. doi:10.1016/0006-291X(91)91718-R. PMID   1718268.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi: 10.1006/viro.2002.1676 . PMID   12482669.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Koefoed-Nielsen PB, Karamperis N, Højskov C, et al. (2007). "The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients". Transpl. Int. 19 (10): 821–7. doi:10.1111/j.1432-2277.2006.00359.x. PMID   16961774. S2CID   1891740.
• Saeki M, Irie Y, Ni L, et al. (2007). "Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation". J. Biol. Chem. 282 (16): 11786–94. doi: 10.1074/jbc.M609347200 . PMID   17324936.
• Jang H, Cho EJ, Youn HD (2007). "A new calcineurin inhibition domain in Cabin1". Biochem. Biophys. Res. Commun. 359 (1): 129–35. doi:10.1016/j.bbrc.2007.05.066. PMID   17531200.