PPRC1

PPRC1
Identifiers
Aliases	PPRC1 , PRC, peroxisome proliferator-activated receptor gamma, coactivator-related 1, PPARG related coactivator 1
External IDs	OMIM: 617462; MGI: 2385096; HomoloGene: 9006; GeneCards: PPRC1; OMA:PPRC1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.32 Start 102,132,994 bp [1] End 102,150,333 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C3 Start 46,033,325 bp [2] End 46,061,354 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube oocyte skin of abdomen upper lobe of left lung left ovary right ovary anterior pituitary secondary oocyte skin of leg gonad Top expressed in otic placode epiblast otic vesicle tail of embryo saccule primitive streak Gonadal ridge human fetus morula morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclear receptor coactivator activity nucleic acid binding transcription coregulator activity RNA binding transcription factor binding Cellular component nucleus nucleoplasm Biological process positive regulation of DNA-binding transcription factor activity mitochondrion organization positive regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23082 226169 Ensembl ENSG00000148840 ENSMUSG00000055491 UniProt Q5VV67 Q6NZN1 RefSeq (mRNA) NM_001288727 NM_001288728 NM_015062 NM_001081214 NM_145504 NM_001346801 RefSeq (protein) NP_001275656 NP_001275657 NP_055877 NP_001074683 NP_001333730 Location (UCSC) Chr 10: 102.13 – 102.15 Mb Chr 19: 46.03 – 46.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene. ^{[5] [6] [7]}

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. ^[7]

Interactions

PPRC1 has been shown to interact with USF2. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000148840 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055491 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
6. Andersson U, Scarpulla RC (May 2001). "PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells". Mol Cell Biol. 21 (11): 3738–49. doi:10.1128/MCB.21.11.3738-3749.2001. PMC   87014 . PMID   11340167.
7. "Entrez Gene: PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1".
8. Moore, Meredith L; Park Edwards A; McMillin Jeanie B (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". J. Biol. Chem. 278 (19). United States: 17263–8. doi: 10.1074/jbc.M210486200 . ISSN   0021-9258. PMID   12611894.

Further reading

• Finck BN, Kelly DP (2006). "PGC-1 coactivators: inducible regulators of energy metabolism in health and disease". J. Clin. Invest. 116 (3): 615–22. doi:10.1172/JCI27794. PMC   1386111 . PMID   16511594.
• Yamagata K, Yoshimochi K, Daitoku H, et al. (2007). "Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner". Int. J. Mol. Med. 19 (5): 751–6. doi: 10.3892/ijmm.19.5.751 . PMID   17390079.
• Srivastava S, Barrett JN, Moraes CT (2007). "PGC-1α/β upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations". Hum. Mol. Genet. 16 (8): 993–1005. doi:10.1093/hmg/ddm045. PMC   2652746 . PMID   17341490.
• Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of Mitochondrial Transcription Specificity Factors (TFB1M and TFB2M) by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators". Mol. Cell. Biol. 25 (4): 1354–66. doi:10.1128/MCB.25.4.1354-1366.2005. PMC   548005 . PMID   15684387.
• Yamamoto T, Shimano H, Nakagawa Y, et al. (2004). "SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes". J. Biol. Chem. 279 (13): 12027–35. doi: 10.1074/jbc.M310333200 . PMID   14722127.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Savagner F, Mirebeau D, Jacques C, et al. (2003). "PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma". Biochem. Biophys. Res. Commun. 310 (3): 779–84. doi:10.1016/j.bbrc.2003.09.076. PMID   14550271.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scarpulla RC (2002). "Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells". Gene. 286 (1): 81–9. doi:10.1016/S0378-1119(01)00809-5. PMID   11943463.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.