PRB1

PRB1
Identifiers
Aliases	PRB1 , PM, PMF, PMS, PRB1L, PRB1M, proline rich protein BstNI subfamily 1, proline rich protein BstNI subfamily 1 (gene/pseudogene)
External IDs	OMIM: 180989 GeneCards: PRB1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	11,395,566 bp
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• molecular function ;
Cellular component	• extracellular region ;
Biological process	• biological process ;
	Sources:Amigo / QuickGO
Orthologs
	5542
	n/a
	ENSG00000275517 ; ENSG00000282673 ; ENSG00000251655
	n/a
	P04280
	n/a
	NM_199354 ; NM_005039 ; NM_199353 ; NM_001367912
	n/a
	NP_005030 ; NP_001354841
	n/a
	Wikidata
View/Edit Human

Last updated September 13, 2021

Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene.^[3]^[4]

The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[4]

Related Research Articles

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Cystatin-S is a protein that in humans is encoded by the CST4 gene.

Histatin 3, also known as HTN3, is a protein which in humans is encoded by the HTN3 gene.

Statherin is a protein in humans that is encoded by the STATH gene. It prevents the precipitation of calcium phosphate in saliva, maintaining a high calcium level in saliva available for remineralisation of tooth enamel and high phosphate levels for buffering.

Carbonic anhydrase 6 is an enzyme that in humans is encoded by the CA6 gene. It is also called 'gustin' because of its presence in saliva, and lower-than-normal levels of salivary zinc in individuals with hypogeusia.

Cystatin-SN is a protein that in humans is encoded by the CST1 gene.

Cysteine-rich secretory protein 3 is a cysteine-rich secretory protein that in humans is encoded by the CRISP3 gene.

Cystatin-SA is a protein that in humans is encoded by the CST2 gene.

Histatin-1 is a protein that in humans is encoded by the HTN1 gene.

Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene.

Amyloid beta A4 precursor protein-binding family B member 3 is a protein that in humans is encoded by the APBB3 gene.

Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene.

WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4 gene.

Salivary acidic proline-rich phosphoprotein 1/2 is a protein that in humans is encoded by the PRH1 gene.

Proline-rich protein 4 is a protein that in humans is encoded by the PRR4 gene.

Proline-rich proteins (PRPs) is a class of intrinsically unstructured proteins (IUP) containing several repeats of a short proline-rich sequence.

Proline-rich protein HaeIII subfamily 2 is a protein that in humans is encoded by the PRH2 gene.

Proline-rich protein 30 is a protein in humans that is encoded for by the PRR30 gene. PRR30 is a member in the family of Proline-rich proteins characterized by their intrinsic lack of structure. Copy number variations in the PRR30 gene have been associated with an increased risk for neurofibromatosis.

References

1 2 3 ENSG00000282673, ENSG00000251655 GRCh38: Ensembl release 89: ENSG00000275517, ENSG00000282673, ENSG00000251655 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Azen EA, Latreille P, Niece RL (Jul 1993). "PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs)". Am J Hum Genet. 53 (1): 264–78. PMC 1682219 . PMID 8317492.
1 2 "Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1".

Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their polymorphisms". Adv. Hum. Genet. 17: 141–99. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. PMID 3055850.
Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092. S2CID 31373141.
Ikemoto S, Minaguchi K, Suzuki K, Tomita K (1977). "New Genetic marker in human parotid saliva (pm)". Science. 197 (4301): 378–9. doi:10.1126/science.877561. PMID 877561.
Castle AM, Stahl LE, Castle JD (1992). "A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum". J. Biol. Chem. 267 (18): 13093–100. doi: 10.1016/S0021-9258(18)42385-X . PMID 1618808.
Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC 1203497 . PMID 2851479.
Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi: 10.1016/S0021-9258(17)39156-1 . PMID 2993301.
Kauffman D, Hofmann T, Bennick A, Keller P (1986). "Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6". Biochemistry. 25 (9): 2387–92. doi:10.1021/bi00357a013. PMID 3521730.
Azen E, Lyons KM, McGonigal T, et al. (1984). "Clones from the human gene complex coding for salivary proline-rich proteins". Proc. Natl. Acad. Sci. U.S.A. 81 (17): 5561–5. doi: 10.1073/pnas.81.17.5561 . PMC 391746 . PMID 6089212.
Saitoh E, Isemura S, Sanada K (1984). "Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H". J. Biochem. 94 (6): 1991–9. doi:10.1093/oxfordjournals.jbchem.a134553. PMID 6671974.
Kauffman D, Wong R, Bennick A, Keller P (1983). "Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair". Biochemistry. 21 (25): 6558–62. doi:10.1021/bi00268a036. PMID 6924859.
Isemura S, Saitoh E, Sanada K (1982). "Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E". J. Biochem. 91 (6): 2067–75. doi:10.1093/oxfordjournals.jbchem.a133900. PMID 7118863.
Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499. S2CID 24058984.
Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC 25286 . PMID 9487127.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi: 10.1046/j.1432-1327.2001.02241.x . PMID 11422372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000282673, ENSG00000251655 GRCh38: Ensembl release 89: ENSG00000275517, ENSG00000282673, ENSG00000251655 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8317492-3] Azen EA, Latreille P, Niece RL (Jul 1993). "PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs)". Am J Hum Genet. 53 (1): 264–78. PMC 1682219 . PMID 8317492.

[entrez-4] 1 2 "Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1".

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PRB1

Related Research Articles

References

Further reading