PRKRIR

THAP12
Identifiers
Aliases	THAP12 , DAP4, P52rIPK, THAP0, PRKRIR, THAP domain containing 12
External IDs	OMIM: 607374 MGI: 1920231 HomoloGene: 37952 GeneCards: THAP12
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,367,269 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus epididymis; ; cancellous bone; ; caput epididymis; ; retinal pigment epithelium; ; secondary oocyte; ; ganglionic eminence; ; body of pancreas; ; lactiferous duct; ; superficial temporal artery;
	Top expressed in
	triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; gastrocnemius muscle; ; digastric muscle; ; intercostal muscle; ; ankle; ; tibialis anterior muscle; ; plantaris muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding ; nucleic acid binding ; protein dimerization activity ; protein binding ; DNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ; nucleoplasm ; cytoplasm ;
Biological process	negative regulation of cell population proliferation ; signal transduction ; regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	5612
	72981
	n/a
	ENSMUSG00000030753
	O43422
	Q9CUX1
	NM_004705
	NM_028410 ; NM_001355114
	NP_004696
	NP_082686 ; NP_001342043
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

52 kDa repressor of the inhibitor of the protein kinase is an enzyme that in humans is encoded by the PRKRIR gene.^[4]^[5]

Interactions

PRKRIR has been shown to interact with STK4 ^[6] and DNAJC3.^[4]

Related Research Articles

Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene.

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.

DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly. As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death. Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.

Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.

Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. The IRF family is a group of transcription factors that are involved in signaling for virus responses in mammals along with regulation of certain cellular functions.

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene. PACT heterodimerizes with and activates protein kinase R. PRKRA mutations have been linked to a rare form of dystonia parkinsonism.

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.

Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.

Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.

DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene.

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene.

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030753 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Gale M Jr; Blakely CM; Hopkins DA; Melville MW; Wambach M; Romano PR; Katze MG (Feb 1998). "Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK". Mol Cell Biol. 18 (2): 859–71. doi:10.1128/mcb.18.2.859. PMC 108797 . PMID 9447982.
↑ "Entrez Gene: PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)".
↑ Lin, Yenshou; Khokhlatchev Andrei; Figeys Daniel; Avruch Joseph (Dec 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. United States. 277 (50): 47991–8001. doi: 10.1074/jbc.M202630200 . ISSN 0021-9258. PMID 12384512.

Mellor H, Proud CG (1991). "A synthetic peptide substrate for initiation factor-2 kinases". Biochem. Biophys. Res. Commun. 178 (2): 430–7. doi:10.1016/0006-291X(91)90125-Q. PMID 1677563.
Polyak SJ, Tang N, Wambach M, et al. (1996). "The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity". J. Biol. Chem. 271 (3): 1702–7. doi: 10.1074/jbc.271.3.1702 . PMID 8576172.
Shi Y, Vattem KM, Sood R, et al. (1998). "Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control". Mol. Cell. Biol. 18 (12): 7499–509. doi:10.1128/MCB.18.12.7499. PMC 109330 . PMID 9819435.
Lu J, O'Hara EB, Trieselmann BA, et al. (1999). "The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha". J. Biol. Chem. 274 (45): 32198–203. doi: 10.1074/jbc.274.45.32198 . PMID 10542257.
Saelens X, Kalai M, Vandenabeele P (2001). "Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation". J. Biol. Chem. 276 (45): 41620–8. doi: 10.1074/jbc.M103674200 . PMID 11555640.
Lin Y, Khokhlatchev A, Figeys D, Avruch J (2003). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50): 47991–8001. doi: 10.1074/jbc.M202630200 . PMID 12384512.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Lee JH, Choi SR, Hwang TH, et al. (2004). "A gene expression in study human gastric adenocarcinoma using a cDNA microarray". The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi. 42 (6): 484–95. PMID 14695705.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This protein-related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030753 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9447982-4] 1 2 Gale M Jr; Blakely CM; Hopkins DA; Melville MW; Wambach M; Romano PR; Katze MG (Feb 1998). "Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK". Mol Cell Biol. 18 (2): 859–71. doi:10.1128/mcb.18.2.859. PMC 108797 . PMID 9447982.

[entrez-5] "Entrez Gene: PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)".

[pmid12384512-6] Lin, Yenshou; Khokhlatchev Andrei; Figeys Daniel; Avruch Joseph (Dec 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. United States. 277 (50): 47991–8001. doi: 10.1074/jbc.M202630200 . ISSN 0021-9258. PMID 12384512.

[1]

[2]

[3]

[4]

[5]

[6]

PRKRIR

Contents

Interactions

Related Research Articles

References

Further reading