PRKRIR

THAP12
Identifiers
Aliases	THAP12 , DAP4, P52rIPK, THAP0, PRKRIR, THAP domain containing 12
External IDs	OMIM: 607374; MGI: 1920231; HomoloGene: 37952; GeneCards: THAP12; OMA:THAP12 - orthologs
Gene location (Mouse) Chr. Chromosome 7 (mouse) [1] Band 7|7 E1 Start 98,352,310 bp [1] End 98,367,269 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon corpus epididymis trabecular bone caput epididymis retinal pigment epithelium secondary oocyte ganglionic eminence body of pancreas lactiferous duct superficial temporal artery Top expressed in triceps brachii muscle temporal muscle sternocleidomastoid muscle vastus lateralis muscle gastrocnemius muscle muscle of thigh digastric muscle medial head of gastrocnemius muscle intercostal muscle ankle More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding nucleic acid binding protein dimerization activity protein binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytoplasm Biological process negative regulation of cell population proliferation signal transduction regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5612 72981 Ensembl n/a ENSMUSG00000030753 UniProt O43422 Q9CUX1 RefSeq (mRNA) NM_004705 NM_028410 NM_001355114 RefSeq (protein) NP_004696 NP_082686 NP_001342043 Location (UCSC) n/a Chr 7: 98.35 – 98.37 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

52 kDa repressor of the inhibitor of the protein kinase is an enzyme that in humans is encoded by the PRKRIR gene. ^{[4] [5]}

Interactions

PRKRIR has been shown to interact with STK4 ^[6] and DNAJC3. ^[4]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000030753 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Gale M Jr; Blakely CM; Hopkins DA; Melville MW; Wambach M; Romano PR; Katze MG (Feb 1998). "Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK". Mol Cell Biol. 18 (2): 859–71. doi:10.1128/mcb.18.2.859. PMC   108797 . PMID   9447982.
5. "Entrez Gene: PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)".
6. Lin, Yenshou; Khokhlatchev Andrei; Figeys Daniel; Avruch Joseph (Dec 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50). United States: 47991–8001. doi: 10.1074/jbc.M202630200 . ISSN   0021-9258. PMID   12384512.

Further reading

• Mellor H, Proud CG (1991). "A synthetic peptide substrate for initiation factor-2 kinases". Biochem. Biophys. Res. Commun. 178 (2): 430–7. doi:10.1016/0006-291X(91)90125-Q. PMID   1677563.
• Polyak SJ, Tang N, Wambach M, et al. (1996). "The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity". J. Biol. Chem. 271 (3): 1702–7. doi: 10.1074/jbc.271.3.1702 . PMID   8576172.
• Shi Y, Vattem KM, Sood R, et al. (1998). "Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control". Mol. Cell. Biol. 18 (12): 7499–509. doi:10.1128/MCB.18.12.7499. PMC   109330 . PMID   9819435.
• Lu J, O'Hara EB, Trieselmann BA, et al. (1999). "The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha". J. Biol. Chem. 274 (45): 32198–203. doi: 10.1074/jbc.274.45.32198 . PMID   10542257.
• Saelens X, Kalai M, Vandenabeele P (2001). "Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation". J. Biol. Chem. 276 (45): 41620–8. doi: 10.1074/jbc.M103674200 . PMID   11555640.
• Lin Y, Khokhlatchev A, Figeys D, Avruch J (2003). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50): 47991–8001. doi: 10.1074/jbc.M202630200 . PMID   12384512.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lee JH, Choi SR, Hwang TH, et al. (2004). "A gene expression in study human gastric adenocarcinoma using a cDNA microarray". The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi. 42 (6): 484–95. PMID   14695705.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.