PRPSAP2

PRPSAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JI4
Identifiers
Aliases	PRPSAP2 , PAP41, phosphoribosyl pyrophosphate synthetase associated protein 2
External IDs	OMIM: 603762; MGI: 2384838; HomoloGene: 2073; GeneCards: PRPSAP2; OMA:PRPSAP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p11.2 Start 18,840,085 bp [1] End 18,931,287 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B2 Start 61,620,476 bp [2] End 61,652,914 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone C1 segment cerebellar hemisphere right hemisphere of cerebellum pons lymph node inferior ganglion of vagus nerve corpus callosum tonsil Top expressed in secondary oocyte ganglionic eminence ventricular zone epiblast zygote morula primary oocyte layer of retina neural layer of retina blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function ribose phosphate diphosphokinase activity enzyme inhibitor activity magnesium ion binding protein binding enzyme regulator activity Cellular component ribose phosphate diphosphokinase complex cytoplasm protein-containing complex Biological process nucleotide biosynthetic process bone development nucleobase-containing compound metabolic process negative regulation of catalytic activity nucleoside metabolic process 5-phosphoribose 1-diphosphate biosynthetic process purine nucleotide biosynthetic process regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5636 212627 Ensembl ENSG00000141127 ENSMUSG00000020528 UniProt O60256 Q8R574 RefSeq (mRNA) NM_001243936 NM_001243940 NM_001243941 NM_001243942 NM_002767 NM_001353096 NM_001353097 NM_001353098 NM_001353099 NM_001353100 NM_001353101 NM_001353102 NM_001353103 NM_001353104 NM_001353105 NM_001353106 NM_001353107 NM_001164242 NM_001164243 NM_001164244 NM_144806 NM_001364086 NM_001364087 NM_001364088 NM_001364090 RefSeq (protein) NP_001230865 NP_001230869 NP_001230870 NP_001230871 NP_002758 NP_001340025 NP_001340026 NP_001340027 NP_001340028 NP_001340029 NP_001340030 NP_001340031 NP_001340032 NP_001340033 NP_001340034 NP_001340035 NP_001340036 NP_001157714 NP_001157715 NP_001157716 NP_659055 NP_001351015 NP_001351016 NP_001351017 NP_001351019 Location (UCSC) Chr 17: 18.84 – 18.93 Mb Chr 11: 61.62 – 61.65 Mb PubMed search [3] [4]
Wikidata
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Phosphoribosyl pyrophosphate synthetase-associated protein 2 is a protein that in humans is encoded by the PRPSAP2 gene. ^[5]

Function

The enzyme phosphoribosyl pyrophosphate synthetase (PRS) catalyzes the formation of phosphoribosyl pyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000141127 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020528 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: phosphoribosyl pyrophosphate synthetase-associated protein 2" . Retrieved 2011-08-30.

Further reading

• Katashima R, Iwahana H, Fujimura M, et al. (1998). "Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein". Biochim. Biophys. Acta. 1396 (3): 245–50. doi:10.1016/S0167-4781(97)00217-0. PMID   9545573.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Katashima R, Iwahana H, Fujimura M, et al. (1998). "Assignment of the human phosphoribosylpyrophosphate synthetase-associated protein 41 gene (PRPSAP2) to 17p11.2-p12". Genomics. 54 (1): 180–1. doi:10.1006/geno.1998.5432. PMID   9806849.
• Low SK, Kuchiba A, Zembutsu H, et al. (2010). "Genome-wide association study of pancreatic cancer in Japanese population". PLOS ONE. 5 (7): e11824. Bibcode:2010PLoSO...511824L. doi: 10.1371/journal.pone.0011824 . PMC   2912284 . PMID   20686608.