PSMG1

PSMG1
Identifiers
Aliases	PSMG1 , C21LRP, DSCR2, LRPC21, PAC-1, PAC1, proteasome assembly chaperone 1
External IDs	OMIM: 605296; MGI: 1860263; HomoloGene: 2759; GeneCards: PSMG1; OMA:PSMG1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.2 Start 39,174,769 bp [1] End 39,183,488 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 C4 Start 95,781,133 bp [2] End 95,792,160 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis gonad rectum endometrium mucosa of transverse colon body of pancreas mucosa of esophagus right adrenal gland right adrenal cortex Top expressed in otic placode saccule otic vesicle primitive streak epiblast embryo endocardial cushion embryo abdominal wall left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding proteasome binding Cellular component cytoplasm Golgi apparatus endoplasmic reticulum nucleus nucleoplasm cytosol Biological process cerebellar granule cell precursor proliferation proteasome assembly proteasome core complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8624 56088 Ensembl ENSG00000183527 ENSMUSG00000022913 UniProt O95456 Q9JK23 RefSeq (mRNA) NM_001261824 NM_003720 NM_203433 NM_001320795 NM_019537 RefSeq (protein) NP_001248753 NP_001307724 NP_003711 NP_982257 NP_062410 Location (UCSC) Chr 21: 39.17 – 39.18 Mb Chr 16: 95.78 – 95.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proteasome assembly chaperone 1 is a protein that in humans is encoded by the PSMG1 gene. ^{[5] [6] [7]}

See also

• Proteasome
• Chaperone

References

1. GRCh38: Ensembl release 89: ENSG00000183527 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022913 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vidal-Taboada JM, Lu A, Pique M, Pons G, Gil J, Oliva R (Jul 2000). "Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation". Biochem Biophys Res Commun. 272 (1): 156–63. Bibcode:2000BBRC..272..156V. doi:10.1006/bbrc.2000.2726. PMID   10872820.
6. Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S (Dec 2006). "Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes". Mol Cell. 24 (6): 977–84. doi: 10.1016/j.molcel.2006.11.015 . PMID   17189198.
7. "Entrez Gene: DSCR2 Down syndrome critical region gene 2".

Further reading

• Vidal-Taboada JM, Sanz S, Egeo A, et al. (1998). "Identification and characterization of a new gene from human chromosome 21 between markers D21S343 and D21S268 encoding a leucine-rich protein". Biochem. Biophys. Res. Commun. 250 (3): 547–54. Bibcode:1998BBRC..250..547V. doi:10.1006/bbrc.1998.9352. PMID   9784380.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Possik PA, Sommer CA, Issa Hori J, et al. (2005). "DSCR2, a Down syndrome critical region protein, is localized to the endoplasmic reticulum of mammalian cells". European Journal of Histochemistry. 48 (3): 267–72. PMID   15590417.
• Vesa J, Brown Y, Greenfield D, Korenberg JR (2005). "Molecular and cellular characterization of the Down syndrome critical region protein 2". Biochem. Biophys. Res. Commun. 328 (1): 235–42. Bibcode:2005BBRC..328..235V. doi:10.1016/j.bbrc.2004.09.226. PMID   15670775.
• Hirano Y, Hendil KB, Yashiroda H, et al. (2005). "A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes". Nature. 437 (7063): 1381–5. Bibcode:2005Natur.437.1381H. doi:10.1038/nature04106. PMID   16251969. S2CID   4424913.