PTBP2

PTBP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQ1, 2MJU, 4CQ1
Identifiers
Aliases	PTBP2 , PTBLP, brPTB, nPTB, polypyrimidine tract binding protein 2
External IDs	OMIM: 608449 MGI: 1860489 HomoloGene: 23162 GeneCards: PTBP2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	96,823,738 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	119,578,115 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; cerebral cortex; ; stomach; ; kidney; ; neocortex; ; prosencephalon; ; lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	mRNA binding ; pre-mRNA binding ; nucleic acid binding ; RNA binding ;
Cellular component	growth cone ; spliceosomal complex ; neuronal cell body ; nucleus ;
Biological process	mRNA splice site selection ; cerebellum development ; mRNA processing ; RNA splicing ; spinal cord development ; regulation of neural precursor cell proliferation ; negative regulation of RNA splicing ;
	Sources:Amigo / QuickGO
Orthologs
	58155
	56195
	ENSG00000117569
	ENSMUSG00000028134
	Q9UKA9
	Q91Z31
NM_001300985 ; NM_001300986 ; NM_001300987 ; NM_001300988 ; NM_001300989 ;
	NM_001300990 ; NM_021190
	NM_019550 ; NM_001310711
NP_001287914 ; NP_001287915 ; NP_001287916 ; NP_001287917 ; NP_001287918 ;
	NP_001287919 ; NP_067013
	NP_001297640 ; NP_062423
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 09, 2022

Polypyrimidine tract binding protein 2, also known as PTBP2, is a protein which in humans is encoded by the PTBP2 gene.^[5]^[6]

Function

The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract-binding protein PTBP1 but it is expressed primarily in the brain.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117569 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028134 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300 . PMID 11003644.
1 2 "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117569 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028134 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11003644-5] Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL (October 2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300 . PMID 11003644.

[entrez-6] 1 2 "Entrez Gene: PTBP2 polypyrimidine tract binding protein 2".

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